Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387184475> ?p ?o ?g. }
- W4387184475 abstract "Oral mucosal wounds exhibit an increased susceptibility to inflammation as a consequence of their direct exposure to a diverse range of microorganisms. This causes pain, slow healing, and other complications that interfere with patients’ daily activities like eating and speaking. Consequently, patients experience a significant decline in their overall quality of life. Therefore, the pursuit of novel treatment approaches is of great importance. In this study, ginsenoside Rg1, a natural active substance extracted from ginseng root, was chosen as a therapeutic agent. It was encapsulated in a screened photo-crosslinked hydrogel scaffold for the treatment of mucosal defects in the rat palate. The results demonstrated that Rg1-hydrogel possessed excellent physical and chemical properties, and that oral mucosa wounds treated with Rg1-hydrogel exhibited the greatest healing performance, as evidenced by more pronounced wound re-epithelialization, increased collagen deposition, and decreased inflammatory infiltration. Subsequent investigations in molecular biology confirmed that Rg1-hydrogel stimulated the secretion of repair-related factors and inhibited the secretion of inflammatory factors. This study demonstrated that the hydrogel containing ginsenoside Rg1 significantly promotes oral mucosal tissue healing in vivo . Based on the findings, it can be inferred that the Rg1-hydrogel has promising prospects for the therapeutic management of oral mucosal wounds." @default.
- W4387184475 created "2023-09-30" @default.
- W4387184475 creator A5006534795 @default.
- W4387184475 creator A5022802322 @default.
- W4387184475 creator A5045921288 @default.
- W4387184475 creator A5056530877 @default.
- W4387184475 creator A5062673325 @default.
- W4387184475 creator A5066407047 @default.
- W4387184475 creator A5087788510 @default.
- W4387184475 date "2023-09-28" @default.
- W4387184475 modified "2023-10-18" @default.
- W4387184475 title "In situ photo-crosslinked hydrogel promotes oral mucosal wound healing through sustained delivery of ginsenoside Rg1" @default.
- W4387184475 cites W1577850276 @default.
- W4387184475 cites W1931315964 @default.
- W4387184475 cites W1999848701 @default.
- W4387184475 cites W2001909877 @default.
- W4387184475 cites W2004186039 @default.
- W4387184475 cites W2043292635 @default.
- W4387184475 cites W2063140011 @default.
- W4387184475 cites W2072607005 @default.
- W4387184475 cites W2515197032 @default.
- W4387184475 cites W2810281348 @default.
- W4387184475 cites W2884102988 @default.
- W4387184475 cites W2893129486 @default.
- W4387184475 cites W2900654827 @default.
- W4387184475 cites W2945442806 @default.
- W4387184475 cites W2955644791 @default.
- W4387184475 cites W2968223269 @default.
- W4387184475 cites W2979317543 @default.
- W4387184475 cites W2983462254 @default.
- W4387184475 cites W2984059297 @default.
- W4387184475 cites W2998367294 @default.
- W4387184475 cites W3009308777 @default.
- W4387184475 cites W3020058005 @default.
- W4387184475 cites W3046570293 @default.
- W4387184475 cites W3047407415 @default.
- W4387184475 cites W3175938459 @default.
- W4387184475 cites W3177609066 @default.
- W4387184475 cites W3185327195 @default.
- W4387184475 cites W3202830971 @default.
- W4387184475 cites W3203872388 @default.
- W4387184475 cites W3204489399 @default.
- W4387184475 cites W3207894203 @default.
- W4387184475 cites W4200352783 @default.
- W4387184475 cites W4206041337 @default.
- W4387184475 cites W4207062628 @default.
- W4387184475 cites W4212786807 @default.
- W4387184475 cites W4220670871 @default.
- W4387184475 cites W4229023016 @default.
- W4387184475 cites W4280502862 @default.
- W4387184475 cites W4282944302 @default.
- W4387184475 cites W4283809444 @default.
- W4387184475 cites W4283833436 @default.
- W4387184475 cites W4289704677 @default.
- W4387184475 cites W4304692698 @default.
- W4387184475 cites W4307337877 @default.
- W4387184475 cites W4307872084 @default.
- W4387184475 cites W4308628736 @default.
- W4387184475 cites W4309040610 @default.
- W4387184475 cites W4309170507 @default.
- W4387184475 cites W4309615783 @default.
- W4387184475 cites W4319216415 @default.
- W4387184475 cites W4321369285 @default.
- W4387184475 cites W4321497979 @default.
- W4387184475 cites W4321748423 @default.
- W4387184475 cites W4362468012 @default.
- W4387184475 cites W4362506410 @default.
- W4387184475 cites W4362556388 @default.
- W4387184475 cites W4364320856 @default.
- W4387184475 cites W4367669888 @default.
- W4387184475 cites W4375847007 @default.
- W4387184475 cites W4375863093 @default.
- W4387184475 cites W4375863435 @default.
- W4387184475 cites W4376612176 @default.
- W4387184475 cites W4379106372 @default.
- W4387184475 cites W4379928515 @default.
- W4387184475 cites W4379967078 @default.
- W4387184475 cites W4380730844 @default.
- W4387184475 doi "https://doi.org/10.3389/fbioe.2023.1252574" @default.
- W4387184475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37840668" @default.
- W4387184475 hasPublicationYear "2023" @default.
- W4387184475 type Work @default.
- W4387184475 citedByCount "0" @default.
- W4387184475 crossrefType "journal-article" @default.
- W4387184475 hasAuthorship W4387184475A5006534795 @default.
- W4387184475 hasAuthorship W4387184475A5022802322 @default.
- W4387184475 hasAuthorship W4387184475A5045921288 @default.
- W4387184475 hasAuthorship W4387184475A5056530877 @default.
- W4387184475 hasAuthorship W4387184475A5062673325 @default.
- W4387184475 hasAuthorship W4387184475A5066407047 @default.
- W4387184475 hasAuthorship W4387184475A5087788510 @default.
- W4387184475 hasBestOaLocation W43871844751 @default.
- W4387184475 hasConcept C142724271 @default.
- W4387184475 hasConcept C150903083 @default.
- W4387184475 hasConcept C185592680 @default.
- W4387184475 hasConcept C203014093 @default.
- W4387184475 hasConcept C204787440 @default.
- W4387184475 hasConcept C207001950 @default.
- W4387184475 hasConcept C2776539398 @default.
- W4387184475 hasConcept C2776914184 @default.