Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387185225> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4387185225 endingPage "48" @default.
- W4387185225 startingPage "43" @default.
- W4387185225 abstract "BACKGROUND. Immunotherapy is an innovative approach to treatment that is changing the paradigm in oncology and is achieving significant results in the fight against malignant tumors including leukemia, melanoma, lung cancer, kidney cancer and many others. This treatment uses the power of the body’s immune system to fight cancer cells. Immunotherapy can lead to long-term remission or even complete disappearance of tumors in patients with certain types of cancer. The success of therapy depends on many factors, including the type of cancer and individual patient characteristics. As with any treatment, patients with immunotherapy may experience side effects. As a result of treatment with pembrolizumab (and other immunotherapeutic drugs), patients may develop endocrine disorders. The most common endocrine side effects include thyroiditis (which can lead to hyper- or hypothyroidism), inflammation of the parathyroid glands, hypophysitis, and diabetes mellitus.
 OBJECTIVE. Based on the literature data, to investigate the possible side effects of immunotherapeutic drugs on the endocrine system.
 MATERIALS AND METHODS. Object: endocrine complications due to immunotherapy. Research method: review of literary sources.
 RESULTS. Among the manifestations of the endocrine system, the most common are thyroid dysfunction and diabetes mellitus. It is important to monitor the levels of thyroid-stimulating hormone (TSH), free T4, blood glucose and glycated hemoglobin for timely detection of endocrine pathology, prevention of unwanted complications and improvement of patients’ quality of life.
 CONCLUSIONS. Immunotherapy is vital for cancer patients. Given the possible development of various side effects, including those from the endocrine system, patients should monitor the main indicators of the thyroid gland (TSH, free T4) and carbohydrate metabolism (blood glucose, glycated hemoglobin) both before starting immunotherapy and during treatment. Patients with pre-existing endocrine disorders require more careful monitoring. It is possible that such patients, in the process of immunotherapy, may require correction of hypoglycemic drugs: speaking of diabetes mellitus, a possible option may be a dose correction of tableted antidiabetic drugs, a change in the therapy regimen or insulin therapy; in diseases of the thyroid gland, the doctor may suggest dose adjustment of thyroid drugs, ultrasound diagnostics and/or fine-needle aspiration biopsy of thyroid nodules." @default.
- W4387185225 created "2023-09-30" @default.
- W4387185225 creator A5038029452 @default.
- W4387185225 creator A5071840718 @default.
- W4387185225 date "2023-09-29" @default.
- W4387185225 modified "2023-09-30" @default.
- W4387185225 title "Endocrine side effects of immunotherapeutic drugs" @default.
- W4387185225 cites W1809627231 @default.
- W4387185225 cites W1982488143 @default.
- W4387185225 cites W1990675339 @default.
- W4387185225 cites W2118982164 @default.
- W4387185225 cites W2128035403 @default.
- W4387185225 cites W2130473166 @default.
- W4387185225 cites W2152897456 @default.
- W4387185225 cites W2153942285 @default.
- W4387185225 cites W2166107256 @default.
- W4387185225 cites W2198093519 @default.
- W4387185225 cites W2277326116 @default.
- W4387185225 cites W2292383635 @default.
- W4387185225 cites W2338494814 @default.
- W4387185225 cites W2522337762 @default.
- W4387185225 cites W2527905628 @default.
- W4387185225 cites W2529904548 @default.
- W4387185225 cites W2547133566 @default.
- W4387185225 cites W2560876009 @default.
- W4387185225 cites W2577007969 @default.
- W4387185225 cites W2578528809 @default.
- W4387185225 cites W2587048937 @default.
- W4387185225 cites W2594042408 @default.
- W4387185225 cites W2605630275 @default.
- W4387185225 cites W2613745448 @default.
- W4387185225 cites W2735117693 @default.
- W4387185225 cites W2736166064 @default.
- W4387185225 cites W2743419024 @default.
- W4387185225 cites W2747107882 @default.
- W4387185225 cites W2753432434 @default.
- W4387185225 cites W2760410509 @default.
- W4387185225 cites W2768429453 @default.
- W4387185225 cites W2783137027 @default.
- W4387185225 cites W2791483720 @default.
- W4387185225 cites W2796582438 @default.
- W4387185225 cites W2805354595 @default.
- W4387185225 cites W2877328171 @default.
- W4387185225 cites W2892640821 @default.
- W4387185225 cites W3003310139 @default.
- W4387185225 doi "https://doi.org/10.32902/2663-0338-2023-3-43-48" @default.
- W4387185225 hasPublicationYear "2023" @default.
- W4387185225 type Work @default.
- W4387185225 citedByCount "0" @default.
- W4387185225 crossrefType "journal-article" @default.
- W4387185225 hasAuthorship W4387185225A5038029452 @default.
- W4387185225 hasAuthorship W4387185225A5071840718 @default.
- W4387185225 hasBestOaLocation W43871852251 @default.
- W4387185225 hasConcept C121608353 @default.
- W4387185225 hasConcept C126322002 @default.
- W4387185225 hasConcept C143998085 @default.
- W4387185225 hasConcept C2777658017 @default.
- W4387185225 hasConcept C2777701055 @default.
- W4387185225 hasConcept C2779761222 @default.
- W4387185225 hasConcept C2780194577 @default.
- W4387185225 hasConcept C2780674031 @default.
- W4387185225 hasConcept C46699223 @default.
- W4387185225 hasConcept C526584372 @default.
- W4387185225 hasConcept C71315377 @default.
- W4387185225 hasConcept C71924100 @default.
- W4387185225 hasConceptScore W4387185225C121608353 @default.
- W4387185225 hasConceptScore W4387185225C126322002 @default.
- W4387185225 hasConceptScore W4387185225C143998085 @default.
- W4387185225 hasConceptScore W4387185225C2777658017 @default.
- W4387185225 hasConceptScore W4387185225C2777701055 @default.
- W4387185225 hasConceptScore W4387185225C2779761222 @default.
- W4387185225 hasConceptScore W4387185225C2780194577 @default.
- W4387185225 hasConceptScore W4387185225C2780674031 @default.
- W4387185225 hasConceptScore W4387185225C46699223 @default.
- W4387185225 hasConceptScore W4387185225C526584372 @default.
- W4387185225 hasConceptScore W4387185225C71315377 @default.
- W4387185225 hasConceptScore W4387185225C71924100 @default.
- W4387185225 hasIssue "3" @default.
- W4387185225 hasLocation W43871852251 @default.
- W4387185225 hasOpenAccess W4387185225 @default.
- W4387185225 hasPrimaryLocation W43871852251 @default.
- W4387185225 hasRelatedWork W107846326 @default.
- W4387185225 hasRelatedWork W1990935649 @default.
- W4387185225 hasRelatedWork W2010645160 @default.
- W4387185225 hasRelatedWork W2030612376 @default.
- W4387185225 hasRelatedWork W2155312245 @default.
- W4387185225 hasRelatedWork W2417281989 @default.
- W4387185225 hasRelatedWork W2996772275 @default.
- W4387185225 hasRelatedWork W3032595363 @default.
- W4387185225 hasRelatedWork W4210439728 @default.
- W4387185225 hasRelatedWork W4226402827 @default.
- W4387185225 isParatext "false" @default.
- W4387185225 isRetracted "false" @default.
- W4387185225 workType "article" @default.