Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387186750> ?p ?o ?g. }
- W4387186750 endingPage "1986" @default.
- W4387186750 startingPage "1986" @default.
- W4387186750 abstract "Methylglyoxal (MG) is a precursor for advanced glycation end-products (AGEs), which have a significant role in diabetes. The present study is designed to probe the immunological response of native and glycated low-density lipoprotein (LDL) in experimental animals. The second part of this study is to probe glycoxidative lesion detection in low-density lipoproteins (LDL) in diabetes subjects with varying disease duration. The neo-epitopes attributed to glycation-induced glycoxidative lesion of LDL in DM patients’ plasma were, analyzed by binding of native and MG-modified LDL immunized animal sera antibodies using an immunochemical assay. The plasma purified human LDL glycation with MG, which instigated modification in LDL. Further, the NewZealand-White rabbits were infused with unmodified natural LDL (N-LDL) and MG-glycatedLDL to probe its immunogenicity. The glycoxidative lesion detection in LDL of DM with disease duration (D.D.) of 5–15 years and D.D. > 15 years was found to be significantly higher as compared to normal healthy subjects (NHS) LDL. The findings support the notion that prolonged duration of diabetes can cause structural alteration in LDL protein molecules, rendering them highly immunogenic in nature. The presence of LDL lesions specific to MG-associated glycoxidation would further help in assessing the progression of diabetes mellitus." @default.
- W4387186750 created "2023-09-30" @default.
- W4387186750 creator A5003892889 @default.
- W4387186750 creator A5008831652 @default.
- W4387186750 creator A5024726175 @default.
- W4387186750 creator A5029564273 @default.
- W4387186750 creator A5030586514 @default.
- W4387186750 creator A5040879382 @default.
- W4387186750 creator A5057831160 @default.
- W4387186750 creator A5058108243 @default.
- W4387186750 creator A5059161145 @default.
- W4387186750 creator A5061059564 @default.
- W4387186750 date "2023-09-29" @default.
- W4387186750 modified "2023-09-30" @default.
- W4387186750 title "Identification of Glycoxidative Lesion in Isolated Low-Density Lipoproteins from Diabetes Mellitus Subjects" @default.
- W4387186750 cites W1942583428 @default.
- W4387186750 cites W1968462329 @default.
- W4387186750 cites W1984801410 @default.
- W4387186750 cites W2001326517 @default.
- W4387186750 cites W2009099723 @default.
- W4387186750 cites W2036734998 @default.
- W4387186750 cites W2049691372 @default.
- W4387186750 cites W2059643569 @default.
- W4387186750 cites W2065799698 @default.
- W4387186750 cites W2069588809 @default.
- W4387186750 cites W2089652914 @default.
- W4387186750 cites W2094142721 @default.
- W4387186750 cites W2094250911 @default.
- W4387186750 cites W2102063342 @default.
- W4387186750 cites W2137258588 @default.
- W4387186750 cites W2196758431 @default.
- W4387186750 cites W2730776610 @default.
- W4387186750 cites W2795556678 @default.
- W4387186750 cites W2919547367 @default.
- W4387186750 cites W2973932371 @default.
- W4387186750 cites W3005065147 @default.
- W4387186750 cites W3127590830 @default.
- W4387186750 cites W3134482301 @default.
- W4387186750 cites W4206828008 @default.
- W4387186750 cites W4292379484 @default.
- W4387186750 cites W4298087163 @default.
- W4387186750 cites W4310117874 @default.
- W4387186750 cites W4317399314 @default.
- W4387186750 cites W4317907232 @default.
- W4387186750 cites W4321429263 @default.
- W4387186750 doi "https://doi.org/10.3390/life13101986" @default.
- W4387186750 hasPublicationYear "2023" @default.
- W4387186750 type Work @default.
- W4387186750 citedByCount "0" @default.
- W4387186750 crossrefType "journal-article" @default.
- W4387186750 hasAuthorship W4387186750A5003892889 @default.
- W4387186750 hasAuthorship W4387186750A5008831652 @default.
- W4387186750 hasAuthorship W4387186750A5024726175 @default.
- W4387186750 hasAuthorship W4387186750A5029564273 @default.
- W4387186750 hasAuthorship W4387186750A5030586514 @default.
- W4387186750 hasAuthorship W4387186750A5040879382 @default.
- W4387186750 hasAuthorship W4387186750A5057831160 @default.
- W4387186750 hasAuthorship W4387186750A5058108243 @default.
- W4387186750 hasAuthorship W4387186750A5059161145 @default.
- W4387186750 hasAuthorship W4387186750A5061059564 @default.
- W4387186750 hasBestOaLocation W43871867501 @default.
- W4387186750 hasConcept C126322002 @default.
- W4387186750 hasConcept C134018914 @default.
- W4387186750 hasConcept C142724271 @default.
- W4387186750 hasConcept C147990577 @default.
- W4387186750 hasConcept C181199279 @default.
- W4387186750 hasConcept C185592680 @default.
- W4387186750 hasConcept C2778163477 @default.
- W4387186750 hasConcept C2778592357 @default.
- W4387186750 hasConcept C2779620165 @default.
- W4387186750 hasConcept C2780072125 @default.
- W4387186750 hasConcept C2781156865 @default.
- W4387186750 hasConcept C55493867 @default.
- W4387186750 hasConcept C555293320 @default.
- W4387186750 hasConcept C62746215 @default.
- W4387186750 hasConcept C71924100 @default.
- W4387186750 hasConceptScore W4387186750C126322002 @default.
- W4387186750 hasConceptScore W4387186750C134018914 @default.
- W4387186750 hasConceptScore W4387186750C142724271 @default.
- W4387186750 hasConceptScore W4387186750C147990577 @default.
- W4387186750 hasConceptScore W4387186750C181199279 @default.
- W4387186750 hasConceptScore W4387186750C185592680 @default.
- W4387186750 hasConceptScore W4387186750C2778163477 @default.
- W4387186750 hasConceptScore W4387186750C2778592357 @default.
- W4387186750 hasConceptScore W4387186750C2779620165 @default.
- W4387186750 hasConceptScore W4387186750C2780072125 @default.
- W4387186750 hasConceptScore W4387186750C2781156865 @default.
- W4387186750 hasConceptScore W4387186750C55493867 @default.
- W4387186750 hasConceptScore W4387186750C555293320 @default.
- W4387186750 hasConceptScore W4387186750C62746215 @default.
- W4387186750 hasConceptScore W4387186750C71924100 @default.
- W4387186750 hasIssue "10" @default.
- W4387186750 hasLocation W43871867501 @default.
- W4387186750 hasOpenAccess W4387186750 @default.
- W4387186750 hasPrimaryLocation W43871867501 @default.
- W4387186750 hasRelatedWork W1564925379 @default.
- W4387186750 hasRelatedWork W1904298261 @default.
- W4387186750 hasRelatedWork W2025648868 @default.