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- W4387187863 abstract "Systemic connective tissue diseases (SCDs) are a group of diseases caused by inadequate autoimmune or immune complex reactions, manifested by damage to various organs and systems. Objective — to present our own experience and to propose an algorithm for the diagnosis of CTDs. Materials and methods. We carried out a clinical analysis of 55 newly diagnosed cases of CTDs in patients who were treated at the Department of Thoracic Surgery and Invasive Diagnostic Methods, from 2010 to 2023. For the purpose of histological verification of the diagnosis, 57 invasive interventions were performed on 55 patients, — 55 video thoracoscopic (VATS) and 2 endobronchial (EVUS) biopsies. Results and discussion. lesions of the cardiovascular system occurred in 30 (54.5%) patients, kidneys — in 26 patients (47.3 %), edematous syndrome — in 31 (56.4 %) patients, hyperthermia — in 22 (40.0 %), anemia — in 23 (41.8 %), increased erythrocyte sedimentation rate — in 34 (61.8 %) cases. As a result of 57 invasive interventions, 79 biopsies of various tissues were obtained: 41 (51.9 %) of the pleura, 25 (31.6 %) of the lung, 11 (13.9 %) of the pericardium, 2 (2.5 %) of the intrathoracic lymph nodes. An algorithm for the diagnosis of SCDs is proposed. Conclusions. Newly diagnosed patients with combined damage to the respiratory, cardiovascular and kidney systems without a history of chronic damage to any of them should be considered as a risk group for further diagnosis of SCDs. The use of VATS biopsies of affected tissues should be the standard of investigation along with immunological confirmation for establishing the type of SCDs. Identification of the type of SCDs should be carried out taking into account clinical manifestations based on the results of pathomorphological examination and serological verification of the diagnosis by specialized specialists." @default.
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- W4387187863 date "2023-09-20" @default.
- W4387187863 modified "2023-09-30" @default.
- W4387187863 title "The Role of Invasive Diagnostics of Systemic Connective Tissue Diseases in Respiratory Inflammation" @default.
- W4387187863 doi "https://doi.org/10.30978/tb-2023-3-32" @default.
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