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• W4387188029 abstract "Shifting the bioprospecting targets toward underexplored bacterial groups combined with genome mining studies contributes to avoiding the rediscovery of known compounds by revealing novel, promising biosynthetic gene clusters (BGCs). With the aim of determining the biosynthetic potential of a novel marine bacterium, strain V10 T , isolated from the Domitian littoral in Italy, a comparative phylogenomic mining study was performed across related photosynthetic bacterial groups from an evolutionary perspective. Studies on polyphasic and taxogenomics showed that this bacterium constitutes a new species, designated Roseibaca domitiana sp. nov. To date, this genus has only one other validly described species, which was isolated from a hypersaline Antarctic lake. The genomic evolutionary study linked to BGC diversity revealed that there is a close relationship between the phylogenetic distance of the members of the photosynthetic genera Roseibaca, Roseinatronobacter , and Rhodobaca and their BGC profiles, whose conservation pattern allows discriminating between these genera. On the contrary, the rest of the species related to Roseibaca domitiana exhibited an individual species pattern unrelated to genome size or source of isolation. This study showed that photosynthetic strains possess a streamlined content of BGCs, of which 94.34% of the clusters with biotechnological interest (NRPS, PKS, RRE, and RiPP) are completely new. Among these stand out T1PKS, exclusive of R. domitiana V10 T , and RRE, highly conserved only in R. domitiana V10 T and R. ekhonensis , both categories of BGCs involved in the synthesis of plant growth-promoting compounds and antitumoral compounds, respectively. In all cases, with very low homology with already patented molecules. Our findings reveal the high biosynthetic potential of infrequently cultured bacterial groups, suggesting the need to redirect attention to microbial minorities as a novel and vast source of bioactive compounds still to be exploited." @default.
• W4387188029 created "2023-09-30" @default.
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• W4387188029 date "2023-09-29" @default.
• W4387188029 modified "2023-10-15" @default.
• W4387188029 title "Biosynthetic gene profiling and genomic potential of the novel photosynthetic marine bacterium Roseibaca domitiana" @default.
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• W4387188029 cites W2096404721 @default.
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• W4387188029 cites W2129203537 @default.
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• W4387188029 cites W2141052558 @default.
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• W4387188029 cites W2164321423 @default.
• W4387188029 cites W2171513236 @default.
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• W4387188029 cites W3095583226 @default.
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• W4387188029 cites W4313649869 @default.
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• W4387188029 doi "https://doi.org/10.3389/fmicb.2023.1238779" @default.
• W4387188029 hasPublicationYear "2023" @default.
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