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- W4387188084 abstract "AbstractIn this study, we focused on the synthesis and molecular docking investigations of hybrid derivatives containing tetrahydrobenzo[b]thiophene. Our aim was to evaluate their potential antibacterial properties. Through our analysis, we aimed to gain insights into the molecular mechanisms that underlie their effectiveness against bacterial infections. A series of tetrahydrobenzo[b]thiophene derivatives were produced through the reaction of various carbonyl groups, including 2-thiophenaldehyde, 2-naphthaldehyde, and 3-acetylindole with (2-amino-N-(4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide). Additionally, the condensing starting material with benzaldehyde, a new derivative linked to substituted pyrimidines was synthesized and named tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4,5-dione. Furthermore, it underwent a reaction with monochloroacetyl chloride to produce another derivative. The production and synthesis processes all involved the use of tetrahydrobenzo[b]thiophene compounds.Keywords: Tetrahydrobenzo[b]thiophenemolecular dockingmonochloroacetylantibacterial assessment AcknowledgmentsThe authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through the large group Research Project under grant number (RGP2/413/44).Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis research is funded by King Khalid University through the large group Research Project under grant number [RGP2/413/44]." @default.
- W4387188084 created "2023-09-30" @default.
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- W4387188084 date "2023-09-29" @default.
- W4387188084 modified "2023-09-30" @default.
- W4387188084 title "Tetrahydrobenzo[ <i>b</i> ]thiophene Derivatives Hybrids: Synthesis and Molecular Docking Investigations for Antibacterial Assessment" @default.
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- W4387188084 doi "https://doi.org/10.1080/10406638.2023.2258256" @default.
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