Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387188532> ?p ?o ?g. }
- W4387188532 abstract "Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes. Adipose-specific peroxisome deficiency impairs thermogenesis by inhibiting cold-induced mitochondrial fission due to decreased mitochondrial membrane content of the peroxisome-derived lipids called plasmalogens. Here, we identify TMEM135 as a critical mediator of the peroxisomal regulation of mitochondrial fission and thermogenesis. Adipose-specific TMEM135 knockout in mice blocks mitochondrial fission, impairs thermogenesis, and increases diet-induced obesity and insulin resistance. Conversely, TMEM135 overexpression promotes mitochondrial division, counteracts obesity and insulin resistance, and rescues thermogenesis in peroxisome-deficient mice. Mechanistically, thermogenic stimuli promote association between peroxisomes and mitochondria and plasmalogen-dependent localization of TMEM135 in mitochondria, where it mediates PKA-dependent phosphorylation and mitochondrial retention of the fission factor Drp1. Together, these results reveal a previously unrecognized inter-organelle communication regulating mitochondrial fission and energy homeostasis and identify TMEM135 as a potential target for therapeutic activation of BAT." @default.
- W4387188532 created "2023-09-30" @default.
- W4387188532 creator A5009379188 @default.
- W4387188532 creator A5014452657 @default.
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- W4387188532 creator A5079794322 @default.
- W4387188532 creator A5086858419 @default.
- W4387188532 creator A5091314474 @default.
- W4387188532 date "2023-09-29" @default.
- W4387188532 modified "2023-10-11" @default.
- W4387188532 title "TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis" @default.
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