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• W4387189895 endingPage "104731" @default.
• W4387189895 startingPage "104731" @default.
• W4387189895 abstract "To investigate enamel remineralization and antimicrobial effect of sodium fluoride (NaF) varnish containing calcium strontium silicate (CSR). CSR was synthesized by sol-gel process and incorporated in 5% NaF varnish at three different concentrations (1%, 2%, and 4% w/v). The treatment/control groups were: 1% CSR+NaF, 2% CSR+NaF, 4% CSR+NaF, NaF, and no treatment. Strontium and fluoride release from the varnishes was evaluated. Sound enamel specimens (n=6) were demineralized, varnish-treated, and subjected to remineralization cycle. Mineral density of enamel specimens was evaluated using micro-CT. Antimicrobial effect of the varnishes on Streptococcus mutans and Lactobacillus acidophilus biofilms was assessed using confocal laser scanning microscopy. The HGF-1 cytotoxicity of the varnishes was examined using CCK-8 assay. Both 2% and 4% CSR+NaF varnishes showed significantly higher F release and remineralization potential than NaF varnish (p<0.05). Dead bacterial proportion of 4% CSR+NaF varnish was significantly higher than NaF varnish (p<0.05). The CFUs values of both S. mutans and L. acidophilus were significantly lower in 4% CSR+NaF group than NaF group (p<0.05). No significant difference in cell viability was observed among the groups (p>0.05). Incorporation of 4% CSR in a NaF varnish significantly enhanced its enamel remineralization and antimicrobial potential with no cytotoxic effect. Dental caries is a major public health problem globally. The study highlights the great potential of CSR-doped NaF varnish as a novel anti-caries agent with synergistic remineralizing and antimicrobial properties to combat early enamel caries lesions in the general population." @default.
• W4387189895 created "2023-09-30" @default.
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• W4387189895 date "2023-11-01" @default.
• W4387189895 modified "2023-10-18" @default.
• W4387189895 title "Enamel remineralization potential and antimicrobial effect of a fluoride varnish containing calcium strontium silicate." @default.
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• W4387189895 doi "https://doi.org/10.1016/j.jdent.2023.104731" @default.
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• W4387189895 hasPublicationYear "2023" @default.
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