Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387190440> ?p ?o ?g. }
- W4387190440 endingPage "105306" @default.
- W4387190440 startingPage "105306" @default.
- W4387190440 abstract "The mitochondrial amidoxime reducing component (mARC) is one of five known molybdenum enzymes in eukaryotes. mARC belongs to the MOSC domain superfamily, a large group of so far poorly studied molybdoenzymes. mARC was initially discovered as the enzyme activating N-hydroxylated prodrugs of basic amidines but has since been shown to also reduce a variety of other N-oxygenated compounds, e.g., toxic nucleobase analogues. Under certain circumstances, mARC might also be involved in reductive nitric oxide synthesis through reduction of nitrite. Recently, mARC enzymes have received a lot of attention due to their apparent involvement in lipid metabolism and, in particular, because many genome-wide association studies have shown a common variant of human mARC1 to have a protective effect against liver disease. The mechanism linking mARC enzymes with lipid metabolism remains unknown. Here, we give a comprehensive overview of what is currently known about mARC enzymes, their substrates, structure and apparent involvement in human disease." @default.
- W4387190440 created "2023-09-30" @default.
- W4387190440 creator A5030682284 @default.
- W4387190440 creator A5044656565 @default.
- W4387190440 creator A5068115355 @default.
- W4387190440 date "2023-09-01" @default.
- W4387190440 modified "2023-10-03" @default.
- W4387190440 title "The mitochondrial amidoxime reducing component (mARC) – from prodrug-activation mechanism to drug-metabolising enzyme and onwards to drug target" @default.
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