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- W4387190966 endingPage "115848" @default.
- W4387190966 startingPage "115848" @default.
- W4387190966 abstract "Janus kinase (JAK) plays a crucial role in intracellular signaling pathways, particularly in cytokine-mediated signal transduction, making them attractive therapeutic targets for a wide range of diseases, including autoimmune disorders, myeloproliferative neoplasms, and inflammatory conditions. The review provides a comprehensive overview of the development and therapeutic potential of small-molecule inhibitors targeting JAK family of proteins in various clinical trials. It also discusses the mechanisms of action, specificity, and selectivity of these inhibitors, shedding light on the challenges associated with achieving target selectivity while minimizing off-target effects. Moreover, the review offers insights into the clinical applications of JAK inhibitors, summarizing the ongoing clinical trials and the Food and Drug Administration (FDA)-approved JAK inhibitors currently available for various diseases. Overall, this review provides a thorough examination of the synthesis and clinical use of typical small-molecule JAK inhibitors in different clinical stages and offers a bright future for the development of novel small-molecule JAK inhibitors." @default.
- W4387190966 created "2023-09-30" @default.
- W4387190966 creator A5007321656 @default.
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- W4387190966 creator A5032109314 @default.
- W4387190966 creator A5036978944 @default.
- W4387190966 creator A5088482310 @default.
- W4387190966 date "2023-12-01" @default.
- W4387190966 modified "2023-10-06" @default.
- W4387190966 title "Synthesis and clinical application of small-molecule inhibitors of Janus kinase" @default.
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