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• W4387190977 endingPage "106147" @default.
• W4387190977 startingPage "106147" @default.
• W4387190977 abstract "Multi-directional deformation exhibited by annulus fibrosus (AF) is contributed by chemo-mechanical interactions among its biomolecular constituents' collagen type I (COL-I), collagen type II (COL-II), proteoglycans (aggrecan and hyaluronan) and water. However, the nature and role of such interactions on AF mechanics are unclear. This work employs a molecular dynamics-cohesive finite element-based multiscale approach to investigate role of COL-I-COL-II interchanging distribution and water concentration (WC) variations from outer annulus (OA) to inner annulus (IA) on collagen-hyaluronan (COL-HYL) interface shear, and the mechanisms by which interface shear impacts fibril sliding during collagen fiber deformation. At first, COL-HYL interface atomistic models are constructed by interchanging COL-I with COL-II and increasing COL-II and WC from 0 to 75%, and 65%-75% respectively. Thereafter, a multiscale approach is employed to develop representative volume elements (RVEs) of collagen fibers by incorporating COL-HYL shear as traction-separation behaviour at fibril-hyaluronan contact. Results show that increasing COL-II and WC increases interface stiffness from 0.6 GPa/nm to 1.2 GPa/nm and reduces interface strength from 155 MPa to 58 MPa from OA to IA, contributed by local hydration alterations. A stiffer and weaker interface enhances fibril sliding with increased straining at the contact - thereby contributing to reduction in modulus from 298 MPa to 198 MPa from OA to IA. Such reduction further contributes to softer mechanical response towards IA, as reported by earlier studies. Presented multiscale analysis provides deeper understanding of hierarchical structure-mechanics relationships in AF and can further aid in developing better substitutes for AF repair." @default.
• W4387190977 created "2023-09-30" @default.
• W4387190977 creator A5016906582 @default.
• W4387190977 creator A5083362385 @default.
• W4387190977 date "2023-11-01" @default.
• W4387190977 modified "2023-10-11" @default.
• W4387190977 title "A multiscale investigation into the role of collagen-hyaluronan interface shear on the mechanical behaviour of collagen fibers in annulus fibrosus – Molecular dynamics-cohesive finite element-based study" @default.
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• W4387190977 doi "https://doi.org/10.1016/j.jmbbm.2023.106147" @default.
• W4387190977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37812947" @default.
• W4387190977 hasPublicationYear "2023" @default.
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