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• W4387203839 endingPage "101750" @default.
• W4387203839 startingPage "101750" @default.
• W4387203839 abstract "Dietary natural components emerged as key supplements for protecting fish against aquatic pollutants. In this study, we explored the efficacy of thymol supplementation (1 or 2 g/kg diet) in alleviating the toxic effects induced by exposing Oreochromis niloticus to zinc oxide nanoparticles (ZON) at 1.14 mg/L (equivalent to 1/5th LC50) for 28 days. Relative to control, the fish treated with ZON showed a reduction in the survival rate and growth performance, with the highest zinc residues detected in the liver, followed by muscle and, finally, gills. Alterations were recorded in serum biochemistry reflecting ZON's hepatotoxicity and nephrotoxicity, along with reductions in growth hormone, T3 (triiodothyronine) and T4 (thyroxine). The intestinal amylase, lipase, and protease activities were suppressed with increases in the intestinal Aeromonas and total bacterial counts in the ZON-exposed group. Elevated tissue levels of MDA (malondialdehyde) and PC (protein carbonyl) content, with depletion of the SOD (superoxide dismutase) and CAT (catalase) activities, and GSH (reduced glutathione) levels were also noted in ZON-exposed group, in addition to upregulation of the hepatic HSP-70 (heat shock protein-70), Caspase-3, and P53 (Tumor suppressor protein). Moreover, histomorphological changes were recorded in the ZON-treated fish's liver and gills. Conversely, concomitant administration of thymol with ZON blunted these toxic impacts in a dose-specific manner. Based on these data, thymol could be an effective dietary supplement for stressed fish." @default.
• W4387203839 created "2023-09-30" @default.
• W4387203839 creator A5004199321 @default.
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• W4387203839 creator A5049296822 @default.
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• W4387203839 creator A5081867084 @default.
• W4387203839 date "2023-12-01" @default.
• W4387203839 modified "2023-10-14" @default.
• W4387203839 title "Thymol-enriched diet alleviates the toxic impacts of zinc oxide nanoparticles on growth performance, blood biochemistry, oxidant/antioxidant status and stress-related genes and histology of liver and gills in Oreochromis niloticus" @default.
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• W4387203839 doi "https://doi.org/10.1016/j.aqrep.2023.101750" @default.
• W4387203839 hasPublicationYear "2023" @default.

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