FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206310> ?p ?o ?g. }

• W4387206310 endingPage "107388" @default.
• W4387206310 startingPage "107388" @default.
• W4387206310 abstract "Stroke diagnosis is dependent on lengthy clinical and neuroimaging assessments, while rapid treatment initiation improves clinical outcome. Currently, more sensitive biomarker assays of both non-coding RNA- and protein biomarkers have improved their detectability, which could accelerate stroke diagnosis. This systematic review and meta-analysis compares non-coding RNA- with protein biomarkers for their potential to diagnose and differentiate acute stroke (subtypes) in (pre-)hospital settings.We performed a systematic review and meta-analysis of studies evaluating diagnostic performance of non-coding RNA- and protein biomarkers to differentiate acute ischemic and hemorrhagic stroke, stroke mimics, and (healthy) controls. Quality appraisal of individual studies was assessed using the QUADAS-2 tool while the meta-analysis was performed with the sROC approach and by assessing pooled sensitivity and specificity, diagnostic odds ratios, positive- and negative likelihood ratios, and the Youden Index.112 studies were included in the systematic review and 42 studies in the meta-analysis containing 11627 patients with ischemic strokes, 2110 patients with hemorrhagic strokes, 1393 patients with a stroke mimic, and 5548 healthy controls. Proteins (IL-6 and S100 calcium-binding protein B (S100B)) and microRNAs (miR-30a) have similar performance in ischemic stroke diagnosis. To differentiate between ischemic- or hemorrhagic strokes, glial fibrillary acidic protein (GFAP) levels and autoantibodies to the NR2 peptide (NR2aAb, a cleavage product of NMDA neuroreceptors) were best performing whereas no investigated protein or non-coding RNA biomarkers differentiated stroke from stroke mimics with high diagnostic potential.Despite sampling time differences, circulating microRNAs (< 24 h) and proteins (< 4,5 h) perform equally well in ischemic stroke diagnosis. GFAP differentiates stroke subtypes, while a biomarker panel of GFAP and NR2aAb improved the sensitivity and specificity of GFAP alone to differentiate stroke." @default.
• W4387206310 created "2023-09-30" @default.
• W4387206310 creator A5010400949 @default.
• W4387206310 creator A5012290900 @default.
• W4387206310 creator A5036911938 @default.
• W4387206310 creator A5056821715 @default.
• W4387206310 creator A5059802318 @default.
• W4387206310 creator A5061133593 @default.
• W4387206310 creator A5067739967 @default.
• W4387206310 date "2023-11-01" @default.
• W4387206310 modified "2023-10-03" @default.
• W4387206310 title "Non-coding RNAs versus protein biomarkers to diagnose and differentiate acute stroke: Systematic review and meta-analysis" @default.
• W4387206310 cites W1529113173 @default.
• W4387206310 cites W1574112015 @default.
• W4387206310 cites W1587120670 @default.
• W4387206310 cites W2027984042 @default.
• W4387206310 cites W2055472916 @default.
• W4387206310 cites W2107638293 @default.
• W4387206310 cites W2111722073 @default.
• W4387206310 cites W2126727011 @default.
• W4387206310 cites W2136982804 @default.
• W4387206310 cites W2138768733 @default.
• W4387206310 cites W2165568749 @default.
• W4387206310 cites W2338573220 @default.
• W4387206310 cites W2529940321 @default.
• W4387206310 cites W2557064274 @default.
• W4387206310 cites W2563714496 @default.
• W4387206310 cites W2608921204 @default.
• W4387206310 cites W2624521710 @default.
• W4387206310 cites W2736228963 @default.
• W4387206310 cites W2736432480 @default.
• W4387206310 cites W2788334838 @default.
• W4387206310 cites W2795447768 @default.
• W4387206310 cites W2948607394 @default.
• W4387206310 cites W2967583138 @default.
• W4387206310 cites W3008964745 @default.
• W4387206310 cites W3047369524 @default.
• W4387206310 cites W3107750320 @default.
• W4387206310 cites W3118104664 @default.
• W4387206310 cites W3128873701 @default.
• W4387206310 cites W3135072251 @default.
• W4387206310 cites W3166314739 @default.
• W4387206310 cites W3179866517 @default.
• W4387206310 cites W3187517317 @default.
• W4387206310 cites W3208996264 @default.
• W4387206310 cites W4225813411 @default.
• W4387206310 cites W4280563502 @default.
• W4387206310 cites W4294215472 @default.
• W4387206310 cites W4313574598 @default.
• W4387206310 doi "https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107388" @default.
• W4387206310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37778160" @default.
• W4387206310 hasPublicationYear "2023" @default.
• W4387206310 type Work @default.
• W4387206310 citedByCount "0" @default.
• W4387206310 crossrefType "journal-article" @default.
• W4387206310 hasAuthorship W4387206310A5010400949 @default.
• W4387206310 hasAuthorship W4387206310A5012290900 @default.
• W4387206310 hasAuthorship W4387206310A5036911938 @default.
• W4387206310 hasAuthorship W4387206310A5056821715 @default.
• W4387206310 hasAuthorship W4387206310A5059802318 @default.
• W4387206310 hasAuthorship W4387206310A5061133593 @default.
• W4387206310 hasAuthorship W4387206310A5067739967 @default.
• W4387206310 hasConcept C126322002 @default.
• W4387206310 hasConcept C127413603 @default.
• W4387206310 hasConcept C157481446 @default.
• W4387206310 hasConcept C204232928 @default.
• W4387206310 hasConcept C2780495277 @default.
• W4387206310 hasConcept C2780645631 @default.
• W4387206310 hasConcept C2781197716 @default.
• W4387206310 hasConcept C55493867 @default.
• W4387206310 hasConcept C58471807 @default.
• W4387206310 hasConcept C60644358 @default.
• W4387206310 hasConcept C71924100 @default.
• W4387206310 hasConcept C78519656 @default.
• W4387206310 hasConcept C86803240 @default.
• W4387206310 hasConcept C95190672 @default.
• W4387206310 hasConceptScore W4387206310C126322002 @default.
• W4387206310 hasConceptScore W4387206310C127413603 @default.
• W4387206310 hasConceptScore W4387206310C157481446 @default.
• W4387206310 hasConceptScore W4387206310C204232928 @default.
• W4387206310 hasConceptScore W4387206310C2780495277 @default.
• W4387206310 hasConceptScore W4387206310C2780645631 @default.
• W4387206310 hasConceptScore W4387206310C2781197716 @default.
• W4387206310 hasConceptScore W4387206310C55493867 @default.
• W4387206310 hasConceptScore W4387206310C58471807 @default.
• W4387206310 hasConceptScore W4387206310C60644358 @default.
• W4387206310 hasConceptScore W4387206310C71924100 @default.
• W4387206310 hasConceptScore W4387206310C78519656 @default.
• W4387206310 hasConceptScore W4387206310C86803240 @default.
• W4387206310 hasConceptScore W4387206310C95190672 @default.
• W4387206310 hasIssue "11" @default.
• W4387206310 hasLocation W43872063101 @default.
• W4387206310 hasLocation W43872063102 @default.
• W4387206310 hasOpenAccess W4387206310 @default.
• W4387206310 hasPrimaryLocation W43872063101 @default.
• W4387206310 hasRelatedWork W2137830333 @default.
• W4387206310 hasRelatedWork W2141818396 @default.
• W4387206310 hasRelatedWork W2369690752 @default.

• next