FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206319> ?p ?o ?g. }

• W4387206319 endingPage "e159" @default.
• W4387206319 startingPage "e159" @default.
• W4387206319 abstract "Stereotactic radiosurgery (SRS) is the standard of care for treating a limited number (<3) of brain metastasis (BMs), which offers reduced neurotoxicity compared to whole brain radiotherapy (WBRT). Contemporary advancements in SRS made it possible to also commonly treat multiple (>4) BMs (mBMs). Emphasizing the value of preserving quality of life (QoL) after SRS, there is an urgent need for a systematic study of potential neurocognitive decline in patients receiving SRS treatment for mBMs. The purpose of this study is to use routine MRIs to predict neurocognitive decline for patients treated with distributed SRS, allowing for timely and effective treatment strategy design.This study uses data from an institutional phase I/II clinical trial to determine the neurocognitive decline in patients with (>6) mBMs treated with distributed SRS. In the first 12 months post-SRS, participants are followed and evaluated with routine MRIs and the Hopkins Verbal Learning Test-Revised (HVLT-R) at 2 to 3-month intervals. Changes in HVLT-Delayed Recall scores between two visits are used to define neurocognitive decline. For each visit, an in-house deep learning model segments 66 cortical and 55 subcortical brain regions of interest (ROIs) from the T1 structural MRI and extracts 253 ROI features, including the surface area and thickness of cortical ROIs, and the volume of all ROIS. The difference in ROI features between two visits, together with other clinical factors (e.g., prescription, number of BMs, etc.), is considered as one sample. The study included 22 subjects with 91 visits, resulting in 171 samples with neurocognitive decline labels. The entire sample set is split into 10 folds on patient level for cross validation. In each fold, feature engineering is conducted to remove redundancy and to select the most-important features. The top 20% most frequently selected features are applied with Support Vector Machine to predict the neurocognitive decline label of each sample.As a preliminary result, the proposed method achieves an accuracy of 76%, with an area under the curve (AUC) of 0.75, sensitivity of 0.65 and specificity of 0.83 for predicting neurocognitive decline in mBMs SRS patients using only routine T1 MRIs. The volume of lateral occipital complex, the thickness of inferior parietal lobe and postcentral gyrus, and the surface area of lateral orbitofrontal cortex and pars triangularis are identified as the 5 most important features for this task.Our method shows promising findings for post-SRS neurocognitive decline prediction solely based on routine baseline and follow-up MRIs. In addition, it can identify critical brain ROIs associated with the post-SRS cognitive function. This method has the potential to assist treatment planning strategy to help preserve patients' QoL." @default.
• W4387206319 created "2023-09-30" @default.
• W4387206319 creator A5019870882 @default.
• W4387206319 creator A5021637920 @default.
• W4387206319 creator A5059684522 @default.
• W4387206319 creator A5064769813 @default.
• W4387206319 creator A5068359755 @default.
• W4387206319 creator A5071400654 @default.
• W4387206319 creator A5073447045 @default.
• W4387206319 creator A5080370589 @default.
• W4387206319 creator A5089791635 @default.
• W4387206319 creator A5092972632 @default.
• W4387206319 date "2023-10-01" @default.
• W4387206319 modified "2023-10-04" @default.
• W4387206319 title "Predicting Neurocognitive Decline in Multiple Brain Metastases Patients Undergoing Distributed Stereotactic Radiosurgery" @default.
• W4387206319 doi "https://doi.org/10.1016/j.ijrobp.2023.06.987" @default.
• W4387206319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37784751" @default.
• W4387206319 hasPublicationYear "2023" @default.
• W4387206319 type Work @default.
• W4387206319 citedByCount "0" @default.
• W4387206319 crossrefType "journal-article" @default.
• W4387206319 hasAuthorship W4387206319A5019870882 @default.
• W4387206319 hasAuthorship W4387206319A5021637920 @default.
• W4387206319 hasAuthorship W4387206319A5059684522 @default.
• W4387206319 hasAuthorship W4387206319A5064769813 @default.
• W4387206319 hasAuthorship W4387206319A5068359755 @default.
• W4387206319 hasAuthorship W4387206319A5071400654 @default.
• W4387206319 hasAuthorship W4387206319A5073447045 @default.
• W4387206319 hasAuthorship W4387206319A5080370589 @default.
• W4387206319 hasAuthorship W4387206319A5089791635 @default.
• W4387206319 hasAuthorship W4387206319A5092972632 @default.
• W4387206319 hasConcept C118552586 @default.
• W4387206319 hasConcept C126322002 @default.
• W4387206319 hasConcept C143998085 @default.
• W4387206319 hasConcept C159110408 @default.
• W4387206319 hasConcept C169900460 @default.
• W4387206319 hasConcept C172467417 @default.
• W4387206319 hasConcept C2779951463 @default.
• W4387206319 hasConcept C2780387249 @default.
• W4387206319 hasConcept C2994444459 @default.
• W4387206319 hasConcept C509974204 @default.
• W4387206319 hasConcept C71924100 @default.
• W4387206319 hasConceptScore W4387206319C118552586 @default.
• W4387206319 hasConceptScore W4387206319C126322002 @default.
• W4387206319 hasConceptScore W4387206319C143998085 @default.
• W4387206319 hasConceptScore W4387206319C159110408 @default.
• W4387206319 hasConceptScore W4387206319C169900460 @default.
• W4387206319 hasConceptScore W4387206319C172467417 @default.
• W4387206319 hasConceptScore W4387206319C2779951463 @default.
• W4387206319 hasConceptScore W4387206319C2780387249 @default.
• W4387206319 hasConceptScore W4387206319C2994444459 @default.
• W4387206319 hasConceptScore W4387206319C509974204 @default.
• W4387206319 hasConceptScore W4387206319C71924100 @default.
• W4387206319 hasIssue "2" @default.
• W4387206319 hasLocation W43872063191 @default.
• W4387206319 hasLocation W43872063192 @default.
• W4387206319 hasOpenAccess W4387206319 @default.
• W4387206319 hasPrimaryLocation W43872063191 @default.
• W4387206319 hasRelatedWork W1482850637 @default.
• W4387206319 hasRelatedWork W2080299590 @default.
• W4387206319 hasRelatedWork W2093944381 @default.
• W4387206319 hasRelatedWork W2153209608 @default.
• W4387206319 hasRelatedWork W2341272897 @default.
• W4387206319 hasRelatedWork W2384708512 @default.
• W4387206319 hasRelatedWork W2394624636 @default.
• W4387206319 hasRelatedWork W2926072733 @default.
• W4387206319 hasRelatedWork W4233017396 @default.
• W4387206319 hasRelatedWork W4243064584 @default.
• W4387206319 hasVolume "117" @default.
• W4387206319 isParatext "false" @default.
• W4387206319 isRetracted "false" @default.
• W4387206319 workType "article" @default.