Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206369> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4387206369 endingPage "e57" @default.
- W4387206369 startingPage "e56" @default.
- W4387206369 abstract "Pleural metastases are common sites for recurrence and progression in patients with thymic malignancies. The management of pleural metastases typically involves surgical resection with or without neoadjuvant or adjuvant systemic therapy. After surgical resection of pleural metastases, the 5-year progression-free survival (PFS) rate is about 29-45%. While radiation therapy (RT) is standardly used in the management of locally-advanced thymic malignancies, the role of RT in patients with pleural metastases in unclear. Intensity-modulated pleural radiation therapy (IMPRINT) is a RT technique currently being used to treat malignant pleural mesothelioma (MPM) patients with 2 intact lungs at centers that specialize in MPM treatment. This IMPRINT technique can potentially be extrapolated to thymic patients with pleural metastases. Because the risk of toxicity is of greater concern for thymic patients given their overall relatively favorable prognosis, the rate of toxicity, particularly radiation pneumonitis, needs to be established in the thymic patient population.This is a single-arm, single institution Phase II study of hemithoracic IMPRINT for patients with pleural metastases from thymic malignancies. The primary endpoint of this study is grade 3 or higher radiation pneumonitis within 4 months of completing RT. Secondary endpoints include any toxicity, progression-free survival, patterns of failure and overall survival. Patients must have a pathologically confirmed diagnosis of a thymic malignancy with radiologic or pathologic evidence of pleural metastases. Thymoma or thymic carcinoma are allowed. Patients may have de novo stage IVA disease or recurrent disease in the pleura. There must be no evidence of extrathoracic metastatic disease or contralateral pleural/pericardial disease. Surgical resection of the pleural nodules (ex: pleurectomy/decortication, debulking/metastasectomy) are allowed. Extrapleural pneumonectomy is not allowed. Patients are excluded if they have undergone prior thoracic radiation therapy preventing hemithoracic pleural IMRT, whereas prior thymic bed radiation and/or prior pleural SBRT are allowed. RT will be administered to the ipsilateral pleura to 50.4 Gy in 28 fractions. An optional dose-painting boost to gross disease up to 60 Gy while respecting normal tissue constraints is allowed. Patients can be treated with photon or proton therapy. Simulation, contouring and RT planning guidelines have been developed. Patients will be followed per protocol at regular intervals for at least 12 months following RT. The expected accrual is 36 patients over 4 years. Further information can be found on clinicaltrials.gov (NCT05354570).To be determined.To be determined." @default.
- W4387206369 created "2023-09-30" @default.
- W4387206369 creator A5008781374 @default.
- W4387206369 creator A5012346270 @default.
- W4387206369 creator A5042405172 @default.
- W4387206369 creator A5047055911 @default.
- W4387206369 creator A5052930984 @default.
- W4387206369 creator A5055965589 @default.
- W4387206369 creator A5060033755 @default.
- W4387206369 creator A5067536094 @default.
- W4387206369 creator A5085812198 @default.
- W4387206369 date "2023-10-01" @default.
- W4387206369 modified "2023-10-17" @default.
- W4387206369 title "Phase II Study of Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) for Patients with Pleural Metastases from Thymic Malignancies" @default.
- W4387206369 doi "https://doi.org/10.1016/j.ijrobp.2023.06.771" @default.
- W4387206369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37785717" @default.
- W4387206369 hasPublicationYear "2023" @default.
- W4387206369 type Work @default.
- W4387206369 citedByCount "0" @default.
- W4387206369 crossrefType "journal-article" @default.
- W4387206369 hasAuthorship W4387206369A5008781374 @default.
- W4387206369 hasAuthorship W4387206369A5012346270 @default.
- W4387206369 hasAuthorship W4387206369A5042405172 @default.
- W4387206369 hasAuthorship W4387206369A5047055911 @default.
- W4387206369 hasAuthorship W4387206369A5052930984 @default.
- W4387206369 hasAuthorship W4387206369A5055965589 @default.
- W4387206369 hasAuthorship W4387206369A5060033755 @default.
- W4387206369 hasAuthorship W4387206369A5067536094 @default.
- W4387206369 hasAuthorship W4387206369A5085812198 @default.
- W4387206369 hasConcept C126322002 @default.
- W4387206369 hasConcept C126838900 @default.
- W4387206369 hasConcept C141071460 @default.
- W4387206369 hasConcept C142724271 @default.
- W4387206369 hasConcept C143998085 @default.
- W4387206369 hasConcept C2776178081 @default.
- W4387206369 hasConcept C2776349617 @default.
- W4387206369 hasConcept C2776517811 @default.
- W4387206369 hasConcept C2777407522 @default.
- W4387206369 hasConcept C2777714996 @default.
- W4387206369 hasConcept C2779159893 @default.
- W4387206369 hasConcept C2779399171 @default.
- W4387206369 hasConcept C2779524853 @default.
- W4387206369 hasConcept C509974204 @default.
- W4387206369 hasConcept C71924100 @default.
- W4387206369 hasConceptScore W4387206369C126322002 @default.
- W4387206369 hasConceptScore W4387206369C126838900 @default.
- W4387206369 hasConceptScore W4387206369C141071460 @default.
- W4387206369 hasConceptScore W4387206369C142724271 @default.
- W4387206369 hasConceptScore W4387206369C143998085 @default.
- W4387206369 hasConceptScore W4387206369C2776178081 @default.
- W4387206369 hasConceptScore W4387206369C2776349617 @default.
- W4387206369 hasConceptScore W4387206369C2776517811 @default.
- W4387206369 hasConceptScore W4387206369C2777407522 @default.
- W4387206369 hasConceptScore W4387206369C2777714996 @default.
- W4387206369 hasConceptScore W4387206369C2779159893 @default.
- W4387206369 hasConceptScore W4387206369C2779399171 @default.
- W4387206369 hasConceptScore W4387206369C2779524853 @default.
- W4387206369 hasConceptScore W4387206369C509974204 @default.
- W4387206369 hasConceptScore W4387206369C71924100 @default.
- W4387206369 hasIssue "2" @default.
- W4387206369 hasLocation W43872063691 @default.
- W4387206369 hasLocation W43872063692 @default.
- W4387206369 hasOpenAccess W4387206369 @default.
- W4387206369 hasPrimaryLocation W43872063691 @default.
- W4387206369 hasRelatedWork W114545845 @default.
- W4387206369 hasRelatedWork W147629913 @default.
- W4387206369 hasRelatedWork W1993423771 @default.
- W4387206369 hasRelatedWork W2019598670 @default.
- W4387206369 hasRelatedWork W2145086605 @default.
- W4387206369 hasRelatedWork W2412126948 @default.
- W4387206369 hasRelatedWork W2419225030 @default.
- W4387206369 hasRelatedWork W2888254860 @default.
- W4387206369 hasRelatedWork W3088391195 @default.
- W4387206369 hasRelatedWork W3094583724 @default.
- W4387206369 hasVolume "117" @default.
- W4387206369 isParatext "false" @default.
- W4387206369 isRetracted "false" @default.
- W4387206369 workType "article" @default.