FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206404> ?p ?o ?g. }

• W4387206404 endingPage "e148" @default.
• W4387206404 startingPage "e147" @default.
• W4387206404 abstract "There has been a paradigm shift in managing multiple brain metastases. Various options include SRS, WBRT, and WBRT with Hippocampal avoidance (HA-WBRT). There is no consensus for the treatment of multiple brain metastases (>3 brain metastases). A new technique that has proven feasible is dose escalation in the form of simultaneous integrated boost. The aim of this study was to compare the dosimetry parameters of HA-WBRT plus simultaneous integrated boost versus HA-WBRT alone in multiple brain metastases.In a prospective trial,16 patients with multiple brain metastasis (≥ 3) from various primaries with good performance scores (ECOG PS ≤ 2) are recruited. All patients underwent CT simulation (1.5 mm slice thickness) and RT plans for HA-WBRT with (SIB) and HA-WBRT alone were made. A 5 mm margin was given to the bilateral hippocampus for Hippocampal Avoidance. In the HA-WBRT plan for the PTV i.e., whole brain plus 3 mm margin minus hippocampal avoidance region (H.A.), a dose of 30 Gy in 10 fractions is prescribed over two weeks. In HA-WBRT with SIB, a dose of 30 Gy in 10 fractions over two weeks is prescribed for the PTV, which is the clinical target volume, minus the hippocampal avoidance region (H.A.) minus the PTV Mets (1 mm margin to the GTV). A simultaneous Integrated Boost of 42.5 Gy in 10 # over two weeks is prescribed for PTVmets. Planning was done using a VMAT technique with 6MV F.F.F. beam energy in a treatment planning software.The mean B/L hippocampus volume is 3.47 cc. The mean dose of PTV D98% in HA-WBRT plans is 27.45 Gy, whereas in HA-WBRT with S.I.B. is 27.36 Gy (p = 0.90). V30 mean dose in HA-WBRT plans is 93.35%, and the mean dose in HA-WBRT SIB is 91.87% (p = 0.12). PTV D2% mean dose in HA-WBRT Is 36.06 Gy, and in HA-WBRT -S.I.B., it is 40.58 (p< 0.001). The mean bilateral hippocampus Dmax in HA-WBRT is 14.85 Gy, and in HA-WBRT-SIB is 14.25 Gy (p = 0.35). The mean Bilateral hippocampus D100% is 9.14 Gy in HA-WBRT and 9.01 Gy in HA-WBRT-SIB (p = 0.54). The mean brainstem Dmax in HA-WBRT is 36.82 Gy compared to 38.55 Gy in HA-WBRT-SIB (p = 0.02).In patients planned for a simultaneous boost along with hippocampal sparing whole brain radiotherapy, the mean dose to the hippocampal region did not increase. The Dmax of Brainstem, optic chiasma is significantly higher in HA-WBRT-). Our study, the mean dose to PTVmets is more than 45 Gy and more than 50 Gy to GTV with a BED of more than 65 Gy (α/ß = 10) to the metastases, which is equivalent to some ablative dose regimens. Simultaneous integrated boost along with hippocampal sparing radiotherapy thus helps in sparing the hippocampus and delivering higher doses to the metastases and intermediate doses to the rest of the brain, addressing the microscopic disease." @default.
• W4387206404 created "2023-09-30" @default.
• W4387206404 creator A5021789193 @default.
• W4387206404 creator A5023955198 @default.
• W4387206404 creator A5034427886 @default.
• W4387206404 creator A5036149412 @default.
• W4387206404 creator A5049876122 @default.
• W4387206404 creator A5058213083 @default.
• W4387206404 creator A5075574744 @default.
• W4387206404 creator A5079629103 @default.
• W4387206404 creator A5089633103 @default.
• W4387206404 date "2023-10-01" @default.
• W4387206404 modified "2023-10-17" @default.
• W4387206404 title "Hippocampal Avoidance Whole BRAIN Radiotherapy (HA-WBRT) with Simultaneous Integrated BOOST (SIB) vs. HA-WBRT in Multiple Brain Metastases: A Dosimetric Comparison" @default.
• W4387206404 doi "https://doi.org/10.1016/j.ijrobp.2023.06.964" @default.
• W4387206404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37784727" @default.
• W4387206404 hasPublicationYear "2023" @default.
• W4387206404 type Work @default.
• W4387206404 citedByCount "0" @default.
• W4387206404 crossrefType "journal-article" @default.
• W4387206404 hasAuthorship W4387206404A5021789193 @default.
• W4387206404 hasAuthorship W4387206404A5023955198 @default.
• W4387206404 hasAuthorship W4387206404A5034427886 @default.
• W4387206404 hasAuthorship W4387206404A5036149412 @default.
• W4387206404 hasAuthorship W4387206404A5049876122 @default.
• W4387206404 hasAuthorship W4387206404A5058213083 @default.
• W4387206404 hasAuthorship W4387206404A5075574744 @default.
• W4387206404 hasAuthorship W4387206404A5079629103 @default.
• W4387206404 hasAuthorship W4387206404A5089633103 @default.
• W4387206404 hasConcept C119857082 @default.
• W4387206404 hasConcept C121608353 @default.
• W4387206404 hasConcept C126322002 @default.
• W4387206404 hasConcept C126838900 @default.
• W4387206404 hasConcept C148762608 @default.
• W4387206404 hasConcept C2778164965 @default.
• W4387206404 hasConcept C2779013556 @default.
• W4387206404 hasConcept C2779911601 @default.
• W4387206404 hasConcept C2989005 @default.
• W4387206404 hasConcept C41008148 @default.
• W4387206404 hasConcept C509974204 @default.
• W4387206404 hasConcept C71924100 @default.
• W4387206404 hasConcept C774472 @default.
• W4387206404 hasConceptScore W4387206404C119857082 @default.
• W4387206404 hasConceptScore W4387206404C121608353 @default.
• W4387206404 hasConceptScore W4387206404C126322002 @default.
• W4387206404 hasConceptScore W4387206404C126838900 @default.
• W4387206404 hasConceptScore W4387206404C148762608 @default.
• W4387206404 hasConceptScore W4387206404C2778164965 @default.
• W4387206404 hasConceptScore W4387206404C2779013556 @default.
• W4387206404 hasConceptScore W4387206404C2779911601 @default.
• W4387206404 hasConceptScore W4387206404C2989005 @default.
• W4387206404 hasConceptScore W4387206404C41008148 @default.
• W4387206404 hasConceptScore W4387206404C509974204 @default.
• W4387206404 hasConceptScore W4387206404C71924100 @default.
• W4387206404 hasConceptScore W4387206404C774472 @default.
• W4387206404 hasIssue "2" @default.
• W4387206404 hasLocation W43872064041 @default.
• W4387206404 hasLocation W43872064042 @default.
• W4387206404 hasOpenAccess W4387206404 @default.
• W4387206404 hasPrimaryLocation W43872064041 @default.
• W4387206404 hasRelatedWork W2357126231 @default.
• W4387206404 hasRelatedWork W2361356017 @default.
• W4387206404 hasRelatedWork W2364925380 @default.
• W4387206404 hasRelatedWork W2372150991 @default.
• W4387206404 hasRelatedWork W2388910868 @default.
• W4387206404 hasRelatedWork W2392311189 @default.
• W4387206404 hasRelatedWork W2397794889 @default.
• W4387206404 hasRelatedWork W2413562009 @default.
• W4387206404 hasRelatedWork W2765644452 @default.
• W4387206404 hasRelatedWork W2767836245 @default.
• W4387206404 hasVolume "117" @default.
• W4387206404 isParatext "false" @default.
• W4387206404 isRetracted "false" @default.
• W4387206404 workType "article" @default.