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- W4387206464 abstract "Immunity: Seeking out secrets of placental protection The same mechanisms that protect the fetus from the mother's immune system could help keep autoimmune and inflammatory diseases at bay. A growing body of evidence suggests that placental cells promote maternal tolerance for fetal tissues that might otherwise be perceived as ‘foreign’. Bitao Liang and colleagues at Celgene Cellular Therapeutics in Warren, New Jersey, USA, examined the role of cultured human ‘placenta-derived adherent cells’ (PDAC® cells), with a view toward developing these cells as therapeutic tools. Cell culture and animal model experiments both demonstrated that PDAC® cells can help restrict proliferation and activation of T-cell subsets associated with certain immune disorders. The authors found that this occurs through direct effects on T cells and also through factors secreted by PDAC® cells. These factors promote development of particular immune cells that help limit the overall immune response." @default.
- W4387206464 created "2023-09-30" @default.
- W4387206464 date "2014-05-01" @default.
- W4387206464 modified "2023-09-30" @default.
- W4387206464 doi "https://doi.org/10.1002/cti2.2014.3.issue-5" @default.
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