FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206501> ?p ?o ?g. }

• W4387206501 endingPage "e109" @default.
• W4387206501 startingPage "e108" @default.
• W4387206501 abstract "With evolving role for targeted and immunomodulatory agents, the survival rate of NSCLC has been improved even with brain metastasis. This study analyzed the outcome of brain metastasis treated with SRS in conjunction with immunotherapy and target therapy as well as chemotherapy.After obtaining institutional review board (IRB) approval, 229 patients with NSCLC with brain metastasis treated with SRS at our institution were retrospectively reviewed from 2008-2021. Demographic information (e.g., age, sex, race), performance status (PS), extracranial metastasis (ECM), sequence of systemic therapy (SST) and surgery for BM (SBM) were reviewed and collected. Overall survival (OS) and intracranial recurrence free survival (ICRFS) were analyzed using the Kaplan-Meier method/Cox regression, and time to each event were measured from the date of the first SRS treatment. All statistical analyses were performed using SAS version 9.4 (Carey, NC).Of the 229 pts, the median age of pts at first SRS was 64.1 (range, 34.8- 83.0 years). 38.6% were biomarker (EGFR/ALK/ROS/PDL1) positive, and 30% were PDL1 positive. 28.8 % had surgery before SRS. The median number of SRS was 1 (range, 1 - 6), and 10 patients received salvage whole brain radiation therapy (WBRT) after SRS. With a median follow-up of 9.6 months (mo), median OS and ICRFS were 14.0 mo and 8.1 mo respectively. On univariate outcome analysis, PS, ECM, SBM and PDL1 were associated with OS while biomarker, SBM and SST were closely related to ICRFS. Pts with poor PS had worse median OS of 8.3 mo compared to 29.1 mo with good PS (p = 0.001). Median OS for no ECM vs. ECM were 20.7 mo vs. 9.6 mo respectively (p = 0.002). Patients who underwent SBM initially had better median OS of 28.7 mo compared to 9.9 mo without SBM (p<0.001). There was a trend of significant impact of positive PDL1 on median OS (21.1 mo vs. 11.7 mo, p = 0.06). Similarly, SBM was found closely related to ICRFS with median ICRFS of 8.1 mo vs. 4.9 mo for those with and without SBM respectively. Both positive biomarker (13.1 mo vs. 6.4 mo, P = 0.17) and SRS first SST (8.1 mo vs. 4.9 mo, p = 0.11) demonstrated a trend of increased median ICRFS. On multivariable analyses, no SBM was linked with worse OS (HR: 1.85; 95% CI:1.15 - 2.97; p = 0.01) and decreased ICRFS (HR: 1.65; 95% CI: 1.09 - 2.51; p = 0.02). Of 31 pts with information on cause of death, 3.2% died from brain metastasis related cause.This study demonstrated effective treatment of brain metastasis in NSCLC with multiple SRSs, especially for patients with favorable prognosis. Of noticed there was only a small number of patients received salvage WBRT and most patients didn't die from brain metastasis related progression." @default.
• W4387206501 created "2023-09-30" @default.
• W4387206501 creator A5012385418 @default.
• W4387206501 creator A5021416995 @default.
• W4387206501 creator A5048874956 @default.
• W4387206501 creator A5088087329 @default.
• W4387206501 creator A5088214603 @default.
• W4387206501 creator A5092972660 @default.
• W4387206501 creator A5092972661 @default.
• W4387206501 date "2023-10-01" @default.
• W4387206501 modified "2023-10-17" @default.
• W4387206501 title "Stereotactic Radiosurgery (SRS) for Brain Metastasis in the Era of Evolving Systemic Treatment (Immunotherapy or Targeted Therapy) in Patients with Non-Small Cell Lung Cancer (NSCLC)" @default.
• W4387206501 doi "https://doi.org/10.1016/j.ijrobp.2023.06.885" @default.
• W4387206501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37784642" @default.
• W4387206501 hasPublicationYear "2023" @default.
• W4387206501 type Work @default.
• W4387206501 citedByCount "0" @default.
• W4387206501 crossrefType "journal-article" @default.
• W4387206501 hasAuthorship W4387206501A5012385418 @default.
• W4387206501 hasAuthorship W4387206501A5021416995 @default.
• W4387206501 hasAuthorship W4387206501A5048874956 @default.
• W4387206501 hasAuthorship W4387206501A5088087329 @default.
• W4387206501 hasAuthorship W4387206501A5088214603 @default.
• W4387206501 hasAuthorship W4387206501A5092972660 @default.
• W4387206501 hasAuthorship W4387206501A5092972661 @default.
• W4387206501 hasConcept C121608353 @default.
• W4387206501 hasConcept C126322002 @default.
• W4387206501 hasConcept C143998085 @default.
• W4387206501 hasConcept C144301174 @default.
• W4387206501 hasConcept C185592680 @default.
• W4387206501 hasConcept C185926286 @default.
• W4387206501 hasConcept C2776256026 @default.
• W4387206501 hasConcept C2777701055 @default.
• W4387206501 hasConcept C2778164965 @default.
• W4387206501 hasConcept C2779013556 @default.
• W4387206501 hasConcept C2780387249 @default.
• W4387206501 hasConcept C2781197716 @default.
• W4387206501 hasConcept C2781230642 @default.
• W4387206501 hasConcept C38180746 @default.
• W4387206501 hasConcept C50382708 @default.
• W4387206501 hasConcept C509974204 @default.
• W4387206501 hasConcept C530470458 @default.
• W4387206501 hasConcept C55493867 @default.
• W4387206501 hasConcept C71924100 @default.
• W4387206501 hasConceptScore W4387206501C121608353 @default.
• W4387206501 hasConceptScore W4387206501C126322002 @default.
• W4387206501 hasConceptScore W4387206501C143998085 @default.
• W4387206501 hasConceptScore W4387206501C144301174 @default.
• W4387206501 hasConceptScore W4387206501C185592680 @default.
• W4387206501 hasConceptScore W4387206501C185926286 @default.
• W4387206501 hasConceptScore W4387206501C2776256026 @default.
• W4387206501 hasConceptScore W4387206501C2777701055 @default.
• W4387206501 hasConceptScore W4387206501C2778164965 @default.
• W4387206501 hasConceptScore W4387206501C2779013556 @default.
• W4387206501 hasConceptScore W4387206501C2780387249 @default.
• W4387206501 hasConceptScore W4387206501C2781197716 @default.
• W4387206501 hasConceptScore W4387206501C2781230642 @default.
• W4387206501 hasConceptScore W4387206501C38180746 @default.
• W4387206501 hasConceptScore W4387206501C50382708 @default.
• W4387206501 hasConceptScore W4387206501C509974204 @default.
• W4387206501 hasConceptScore W4387206501C530470458 @default.
• W4387206501 hasConceptScore W4387206501C55493867 @default.
• W4387206501 hasConceptScore W4387206501C71924100 @default.
• W4387206501 hasIssue "2" @default.
• W4387206501 hasLocation W43872065011 @default.
• W4387206501 hasLocation W43872065012 @default.
• W4387206501 hasOpenAccess W4387206501 @default.
• W4387206501 hasPrimaryLocation W43872065011 @default.
• W4387206501 hasRelatedWork W1576215238 @default.
• W4387206501 hasRelatedWork W2026176237 @default.
• W4387206501 hasRelatedWork W2163132578 @default.
• W4387206501 hasRelatedWork W2357126231 @default.
• W4387206501 hasRelatedWork W2376213003 @default.
• W4387206501 hasRelatedWork W2388910868 @default.
• W4387206501 hasRelatedWork W2486207447 @default.
• W4387206501 hasRelatedWork W2517198330 @default.
• W4387206501 hasRelatedWork W3007968561 @default.
• W4387206501 hasRelatedWork W4362532615 @default.
• W4387206501 hasVolume "117" @default.
• W4387206501 isParatext "false" @default.
• W4387206501 isRetracted "false" @default.
• W4387206501 workType "article" @default.