FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206693> ?p ?o ?g. }

• W4387206693 endingPage "e157" @default.
• W4387206693 startingPage "e156" @default.
• W4387206693 abstract "The recently completed RTOG 0539 supports fractionated radiation therapy for patients categorized as having intermediate (3 yr PFS 93.8%) or high-risk (3 yr LC 68.9%) meningiomas. Stereotactic radiosurgery (SRS) has not been widely established in the treatment of WHO grade 2 atypical meningiomas given concern that there is a greater risk of microscopic infiltration and therefore requires larger margins than safely achievable with SRS. We look to review a consecutive cohort of patients at our institution who have been diagnosed with atypical meningioma treated with either single fraction Gamma Knife SRS (GK-sfSRS) or hypofractionated Gamma Knife SRS (GK-hfSRS). We review both control rates and patterns of failure.Patients diagnosed with intermediate or high-risk WHO grade 2 meningioma per RTOG 0539 classification, without a history of prior radiation (RT) and treated with either GK-sfSRS or GK-hfSRS between 2014 to 2021 at our institution, were included. Patient charts were reviewed, and follow-up data were analyzed for local control (LC) and failure patterns. Local failure was defined as tumor recurrence within the prescription isodose line, marginal was ≤5 mm outside the prescription isodose line, and distant was >5 mm outside of the prescription isodose line Primary outcome was LC, and secondary outcomes were overall survival (OS) and progression free survival (PFS).We identified 47 pathologically confirmed WHO grade 2 meningiomas in 27 patients. 33 lesions were treated with GK-sfSRS and 14 lesions with GK-hfSRS. 6 lesions were intermediate risk, and 41 were high-risk per RTOG 0539. With a median follow up of 36 months (range 2-86 mo), the 3yr LC was 82.7%, PFS was 83.1%, and OS was 96.3%. A total of 4 patients with 8 lesions failed treatment - all with high-risk disease. All failures were local (4) or marginal (4). The 4 local failures were all from a single patient with 4 distinct meningiomas that were treated with GK-sfSRS without surgical resection. The 4 marginal failures were all in patients treated with GK-sfSRS. There were no failures in patients treated with GK-hfSRS.Our institutional data for patients with atypical meningiomas treated with radiosurgical techniques compare favorably to the patients treated with EBRT in RTOG 0539, though longer follow-up is needed to confirm these findings. Outside of one patient, no patients developed recurrence within the prescription volume. There were 4 tumors with marginal failures, suggesting that additional dural margins than what were prescribed may be meaningful. At our institution, we are increasingly moving to hypofractionated radiosurgery with 5 mm of dural margin when using radiosurgical techniques for high-risk atypical meningioma. However, longer term follow-up is needed to validate the use of radiosurgical techniques in atypical meningioma." @default.
• W4387206693 created "2023-09-30" @default.
• W4387206693 creator A5012278870 @default.
• W4387206693 creator A5024829093 @default.
• W4387206693 creator A5029802910 @default.
• W4387206693 creator A5067182017 @default.
• W4387206693 creator A5076601795 @default.
• W4387206693 creator A5077778024 @default.
• W4387206693 creator A5082538167 @default.
• W4387206693 creator A5083081815 @default.
• W4387206693 date "2023-10-01" @default.
• W4387206693 modified "2023-10-17" @default.
• W4387206693 title "Clinical Outcomes and Patterns of Failure in Patients with High-Risk Atypical Meningioma Treated with Single Fraction vs. Hypofractionated Gamma Knife Radiosurgery" @default.
• W4387206693 doi "https://doi.org/10.1016/j.ijrobp.2023.06.982" @default.
• W4387206693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37784745" @default.
• W4387206693 hasPublicationYear "2023" @default.
• W4387206693 type Work @default.
• W4387206693 citedByCount "0" @default.
• W4387206693 crossrefType "journal-article" @default.
• W4387206693 hasAuthorship W4387206693A5012278870 @default.
• W4387206693 hasAuthorship W4387206693A5024829093 @default.
• W4387206693 hasAuthorship W4387206693A5029802910 @default.
• W4387206693 hasAuthorship W4387206693A5067182017 @default.
• W4387206693 hasAuthorship W4387206693A5076601795 @default.
• W4387206693 hasAuthorship W4387206693A5077778024 @default.
• W4387206693 hasAuthorship W4387206693A5082538167 @default.
• W4387206693 hasAuthorship W4387206693A5083081815 @default.
• W4387206693 hasConcept C126322002 @default.
• W4387206693 hasConcept C126838900 @default.
• W4387206693 hasConcept C141071460 @default.
• W4387206693 hasConcept C2779160599 @default.
• W4387206693 hasConcept C2780387249 @default.
• W4387206693 hasConcept C2989005 @default.
• W4387206693 hasConcept C2994042627 @default.
• W4387206693 hasConcept C509974204 @default.
• W4387206693 hasConcept C71924100 @default.
• W4387206693 hasConcept C72563966 @default.
• W4387206693 hasConceptScore W4387206693C126322002 @default.
• W4387206693 hasConceptScore W4387206693C126838900 @default.
• W4387206693 hasConceptScore W4387206693C141071460 @default.
• W4387206693 hasConceptScore W4387206693C2779160599 @default.
• W4387206693 hasConceptScore W4387206693C2780387249 @default.
• W4387206693 hasConceptScore W4387206693C2989005 @default.
• W4387206693 hasConceptScore W4387206693C2994042627 @default.
• W4387206693 hasConceptScore W4387206693C509974204 @default.
• W4387206693 hasConceptScore W4387206693C71924100 @default.
• W4387206693 hasConceptScore W4387206693C72563966 @default.
• W4387206693 hasIssue "2" @default.
• W4387206693 hasLocation W43872066931 @default.
• W4387206693 hasLocation W43872066932 @default.
• W4387206693 hasOpenAccess W4387206693 @default.
• W4387206693 hasPrimaryLocation W43872066931 @default.
• W4387206693 hasRelatedWork W1815512617 @default.
• W4387206693 hasRelatedWork W1971665703 @default.
• W4387206693 hasRelatedWork W2003021578 @default.
• W4387206693 hasRelatedWork W2153808903 @default.
• W4387206693 hasRelatedWork W2383787703 @default.
• W4387206693 hasRelatedWork W2423336791 @default.
• W4387206693 hasRelatedWork W2466721991 @default.
• W4387206693 hasRelatedWork W2945229280 @default.
• W4387206693 hasRelatedWork W3093519082 @default.
• W4387206693 hasRelatedWork W4235011506 @default.
• W4387206693 hasVolume "117" @default.
• W4387206693 isParatext "false" @default.
• W4387206693 isRetracted "false" @default.
• W4387206693 workType "article" @default.