FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206768> ?p ?o ?g. }

• W4387206768 endingPage "e459" @default.
• W4387206768 startingPage "e459" @default.
• W4387206768 abstract "Secondary CNS lymphoma (SCNSL) is a challenging clinical scenario observed in 2-5% of non-Hodgkin lymphoma patients, for which a standard of care has not been defined. We studied the indications for, and outcomes of SCNSL patients referred for radiotherapy (RT).We identified patients with aggressive B cell lymphoma who received brain RT for SCNSL between 1999-2023 at a tertiary cancer center. Patients were grouped and analyzed by RT indication. Overall survival (OS) was determined from RT start using the Kaplan-Meier method. OS analysis comparing patients who did and did not receive therapy after RT was landmarked at 60 days from start of RT to minimize immortal time bias. SCNSL-directed therapy is defined as systemic therapy for the treatment of SCNSL, as opposed to CNS prophylaxis.We identified 99 SCNSL patients treated with RT. To account for the heterogeneity of RT referrals, we focused on the most common indication: salvage of radiographic progression after SCNSL-directed systemic therapy (n = 58). Among this group, median age was 62 (interquartile range [IQR]: 48-69) and 86% had diffuse large B cell histology. At initial lymphoma diagnosis, 10% of patients had CNS involvement, 90% received Rituximab-based therapy, and 25% received prior CNS prophylaxis. For SCNSL directed therapy, 90% received methotrexate (MTX)-based regimen. Median time from initial SCNSL diagnosis to RT was 4.4 months (IQR 1.7-7.0), with a median of 2.0 lines of therapy prior to RT (IQR 1.0-3.0). 86% of patients were symptomatic at RT with median KPS of 70 (IQR: 60-80). RT targets included whole brain (86%) and partial brain (14%). 1 patient had craniospinal RT. Median RT dose was 30 Gy (IQR: 24-30) over 10 fractions. Median OS for the entire salvage cohort was 3.5 months (m). Landmark analysis 2m post RT showed that median OS differed when patients were stratified by receipt of further therapy: CAR-T (9.4m, n = 4), hematopoietic cell transplant (8.5m, n = 6), other systemic therapy (4.4m, n = 17), no systemic therapy (0.6m, n = 10) (p = 0.0004). 29% of patients who received further therapy after RT achieved long term survival.In our cohort, most SCNSL patients are referred for salvage RT, with a median OS of 3.5m. 86% of patients had neurologic symptoms after having failed a median of 2 lines of SCNSL-directed therapy; the clinical urgency of this scenario implies that without RT, patients may not have been suitable candidates for further therapy. However, among patients for whom RT was successfully used to bridge to additional therapy, 29% could achieve long-term survival. This study supports further investigation of RT as a combined modality strategy for relapsed/refractory SCNSL, including with emerging cellular therapies." @default.
• W4387206768 created "2023-09-30" @default.
• W4387206768 creator A5007588773 @default.
• W4387206768 creator A5008761191 @default.
• W4387206768 creator A5011340477 @default.
• W4387206768 creator A5023759382 @default.
• W4387206768 creator A5026117937 @default.
• W4387206768 creator A5041294917 @default.
• W4387206768 creator A5045878027 @default.
• W4387206768 creator A5047384277 @default.
• W4387206768 creator A5048304251 @default.
• W4387206768 creator A5054664737 @default.
• W4387206768 creator A5057053281 @default.
• W4387206768 creator A5058490970 @default.
• W4387206768 creator A5074971164 @default.
• W4387206768 creator A5090759974 @default.
• W4387206768 creator A5091792722 @default.
• W4387206768 date "2023-10-01" @default.
• W4387206768 modified "2023-10-17" @default.
• W4387206768 title "Salvage Radiotherapy as a Bridge for Relapsed Secondary CNS Lymphoma" @default.
• W4387206768 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1654" @default.
• W4387206768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37785470" @default.
• W4387206768 hasPublicationYear "2023" @default.
• W4387206768 type Work @default.
• W4387206768 citedByCount "0" @default.
• W4387206768 crossrefType "journal-article" @default.
• W4387206768 hasAuthorship W4387206768A5007588773 @default.
• W4387206768 hasAuthorship W4387206768A5008761191 @default.
• W4387206768 hasAuthorship W4387206768A5011340477 @default.
• W4387206768 hasAuthorship W4387206768A5023759382 @default.
• W4387206768 hasAuthorship W4387206768A5026117937 @default.
• W4387206768 hasAuthorship W4387206768A5041294917 @default.
• W4387206768 hasAuthorship W4387206768A5045878027 @default.
• W4387206768 hasAuthorship W4387206768A5047384277 @default.
• W4387206768 hasAuthorship W4387206768A5048304251 @default.
• W4387206768 hasAuthorship W4387206768A5054664737 @default.
• W4387206768 hasAuthorship W4387206768A5057053281 @default.
• W4387206768 hasAuthorship W4387206768A5058490970 @default.
• W4387206768 hasAuthorship W4387206768A5074971164 @default.
• W4387206768 hasAuthorship W4387206768A5090759974 @default.
• W4387206768 hasAuthorship W4387206768A5091792722 @default.
• W4387206768 hasConcept C119060515 @default.
• W4387206768 hasConcept C126322002 @default.
• W4387206768 hasConcept C141071460 @default.
• W4387206768 hasConcept C143998085 @default.
• W4387206768 hasConcept C2776694085 @default.
• W4387206768 hasConcept C2778559949 @default.
• W4387206768 hasConcept C2779338263 @default.
• W4387206768 hasConcept C2780653079 @default.
• W4387206768 hasConcept C2780775027 @default.
• W4387206768 hasConcept C2781059491 @default.
• W4387206768 hasConcept C2781413609 @default.
• W4387206768 hasConcept C509974204 @default.
• W4387206768 hasConcept C71924100 @default.
• W4387206768 hasConceptScore W4387206768C119060515 @default.
• W4387206768 hasConceptScore W4387206768C126322002 @default.
• W4387206768 hasConceptScore W4387206768C141071460 @default.
• W4387206768 hasConceptScore W4387206768C143998085 @default.
• W4387206768 hasConceptScore W4387206768C2776694085 @default.
• W4387206768 hasConceptScore W4387206768C2778559949 @default.
• W4387206768 hasConceptScore W4387206768C2779338263 @default.
• W4387206768 hasConceptScore W4387206768C2780653079 @default.
• W4387206768 hasConceptScore W4387206768C2780775027 @default.
• W4387206768 hasConceptScore W4387206768C2781059491 @default.
• W4387206768 hasConceptScore W4387206768C2781413609 @default.
• W4387206768 hasConceptScore W4387206768C509974204 @default.
• W4387206768 hasConceptScore W4387206768C71924100 @default.
• W4387206768 hasIssue "2" @default.
• W4387206768 hasLocation W43872067681 @default.
• W4387206768 hasLocation W43872067682 @default.
• W4387206768 hasOpenAccess W4387206768 @default.
• W4387206768 hasPrimaryLocation W43872067681 @default.
• W4387206768 hasRelatedWork W1598567296 @default.
• W4387206768 hasRelatedWork W1991224672 @default.
• W4387206768 hasRelatedWork W1996279342 @default.
• W4387206768 hasRelatedWork W2092467128 @default.
• W4387206768 hasRelatedWork W2222777061 @default.
• W4387206768 hasRelatedWork W2362342713 @default.
• W4387206768 hasRelatedWork W2403773722 @default.
• W4387206768 hasRelatedWork W3024712659 @default.
• W4387206768 hasRelatedWork W3031860663 @default.
• W4387206768 hasRelatedWork W3151167373 @default.
• W4387206768 hasVolume "117" @default.
• W4387206768 isParatext "false" @default.
• W4387206768 isRetracted "false" @default.
• W4387206768 workType "article" @default.