FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206798> ?p ?o ?g. }

• W4387206798 endingPage "e191" @default.
• W4387206798 startingPage "e191" @default.
• W4387206798 abstract "Ventricular tachycardia is a potentially life-threatening cardiac condition that is associated with significant morbidity and mortality. Despite advances in medical therapies, implantable cardioverter-defibrillator (ICD) and catheter ablative therapy (CAT), some patients continue to suffer recurrent VT. SCAR is a highly accurate, non-invasive, and novel ablative therapeutic option that has shown promising results in the treatment of refractory VT patients associated with structural heart disease. Early case series and subsequent prospective clinical trials have demonstrated SCAR to be well-tolerated with acceptable safety profiles and consistently decreased VT episodes in VT patients, who failed all conventional antiarrhythmic medications and CAT. The aim of the current study is to report the efficacy and safety/tolerability of SCAR in ICD-dependent patients with refractory VT in Western Australia, Australia.Seven patients with recurrent refractory VT, deemed high risk or non-suitable for CAT, were referred to GenesisCare at Fiona Stanley Hospital, Western Australia for SCAR between July 2020 and November 2022. Target volume definition and delineation involved interdisciplinary teams by combining all available clinical, electrophysiological mapping and diagnostic/planning cardiac imaging data to generate radiotherapy plans. Patients were treated whilst awake, with a single dose of 25 Gy using VMAT technique on the Synergy Linac with stereotactic X-ray tool capability. Efficacy was assessed by counting the number of episodes of VT and ICD shocks after SCAR. Safety and tolerability were evaluated by treatment related toxicities during follow up.Of the seven patients referred for SCAR, only five received SCAR as two patients died from their refractory VT before their radiotherapy. For the patients receiving SCAR with at least 6 months follow-up, overall reduction in VT episodes and ICD shocks was 95% and 85%, respectively. No significant treatment-related toxicities were documented during follow-up. Two patients had died. Neither of their deaths were directly attributed to their radiotherapy. One patient died after requesting to cease her antiarrhythmic medications and to have her ICD switched off 2 days after SCAR (against medical advice). The other patient died 431 days after SCAR from aspiration pneumonia after fracturing her cervical spine following a fall at home and was unrelated to her VT.Our data reflects international experience in terms of treatment efficacy and safety profiles of SCAR for patients with refractory VT. SCAR is increasingly recognized as an alternative cardiac ablative option for ICD-dependent VT patients who failed all conventional antiarrhythmic treatments. Nonetheless, careful patient selection and longer-term follow-up are required to ensure the optimal treatment outcomes can be achieved in these patients." @default.
• W4387206798 created "2023-09-30" @default.
• W4387206798 creator A5024160417 @default.
• W4387206798 creator A5073080864 @default.
• W4387206798 creator A5082663721 @default.
• W4387206798 creator A5092972706 @default.
• W4387206798 date "2023-10-01" @default.
• W4387206798 modified "2023-10-17" @default.
• W4387206798 title "Stereotactic Cardiac Ablative Radiotherapy (SCAR) for Refractory Ventricular Tachycardia: Western Australia Experience" @default.
• W4387206798 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1056" @default.
• W4387206798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37784827" @default.
• W4387206798 hasPublicationYear "2023" @default.
• W4387206798 type Work @default.
• W4387206798 citedByCount "0" @default.
• W4387206798 crossrefType "journal-article" @default.
• W4387206798 hasAuthorship W4387206798A5024160417 @default.
• W4387206798 hasAuthorship W4387206798A5073080864 @default.
• W4387206798 hasAuthorship W4387206798A5082663721 @default.
• W4387206798 hasAuthorship W4387206798A5092972706 @default.
• W4387206798 hasConcept C121332964 @default.
• W4387206798 hasConcept C126322002 @default.
• W4387206798 hasConcept C126838900 @default.
• W4387206798 hasConcept C141071460 @default.
• W4387206798 hasConcept C142424586 @default.
• W4387206798 hasConcept C164705383 @default.
• W4387206798 hasConcept C19617505 @default.
• W4387206798 hasConcept C197934379 @default.
• W4387206798 hasConcept C2776131983 @default.
• W4387206798 hasConcept C2776331378 @default.
• W4387206798 hasConcept C2777093960 @default.
• W4387206798 hasConcept C2778375690 @default.
• W4387206798 hasConcept C2778902805 @default.
• W4387206798 hasConcept C2780387249 @default.
• W4387206798 hasConcept C509974204 @default.
• W4387206798 hasConcept C535046627 @default.
• W4387206798 hasConcept C71924100 @default.
• W4387206798 hasConcept C87355193 @default.
• W4387206798 hasConceptScore W4387206798C121332964 @default.
• W4387206798 hasConceptScore W4387206798C126322002 @default.
• W4387206798 hasConceptScore W4387206798C126838900 @default.
• W4387206798 hasConceptScore W4387206798C141071460 @default.
• W4387206798 hasConceptScore W4387206798C142424586 @default.
• W4387206798 hasConceptScore W4387206798C164705383 @default.
• W4387206798 hasConceptScore W4387206798C19617505 @default.
• W4387206798 hasConceptScore W4387206798C197934379 @default.
• W4387206798 hasConceptScore W4387206798C2776131983 @default.
• W4387206798 hasConceptScore W4387206798C2776331378 @default.
• W4387206798 hasConceptScore W4387206798C2777093960 @default.
• W4387206798 hasConceptScore W4387206798C2778375690 @default.
• W4387206798 hasConceptScore W4387206798C2778902805 @default.
• W4387206798 hasConceptScore W4387206798C2780387249 @default.
• W4387206798 hasConceptScore W4387206798C509974204 @default.
• W4387206798 hasConceptScore W4387206798C535046627 @default.
• W4387206798 hasConceptScore W4387206798C71924100 @default.
• W4387206798 hasConceptScore W4387206798C87355193 @default.
• W4387206798 hasIssue "2" @default.
• W4387206798 hasLocation W43872067981 @default.
• W4387206798 hasLocation W43872067982 @default.
• W4387206798 hasOpenAccess W4387206798 @default.
• W4387206798 hasPrimaryLocation W43872067981 @default.
• W4387206798 hasRelatedWork W1489717041 @default.
• W4387206798 hasRelatedWork W2107697672 @default.
• W4387206798 hasRelatedWork W2109512293 @default.
• W4387206798 hasRelatedWork W2277629140 @default.
• W4387206798 hasRelatedWork W2378369323 @default.
• W4387206798 hasRelatedWork W2896445697 @default.
• W4387206798 hasRelatedWork W2898344935 @default.
• W4387206798 hasRelatedWork W3041020771 @default.
• W4387206798 hasRelatedWork W3215795069 @default.
• W4387206798 hasRelatedWork W4283117754 @default.
• W4387206798 hasVolume "117" @default.
• W4387206798 isParatext "false" @default.
• W4387206798 isRetracted "false" @default.
• W4387206798 workType "article" @default.