FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387206989> ?p ?o ?g. }

• W4387206989 endingPage "e425" @default.
• W4387206989 startingPage "e425" @default.
• W4387206989 abstract "To evaluate the treatment outcomes and toxicity of definitive radiotherapy (RT) for prostate cancer (PC) patients using the simultaneous integrated boost (SIB) technique to intraprostatic lesion (IPL).All the patients received 78 Gy for their prostate ± seminal vesicles and 86 Gy for the IPL using the SIB technique. High-risk patients received pelvic nodal irradiation. The pelvic lymphatic field received 46-54 Gy of radiation. Univariable and multivariable analyses were conducted of the prognostic factors for freedom from biochemical failure (FFBF), progression-free survival (PFS), and PC-specific survival (PCSS) of 619 PC patients who received definitive RT between September 2012 and August 2021. Predictors of late Grade ≥ 2 genitourinary (GU) and gastrointestinal (GI) toxicities were also identified using logistic regression.The median age of the entire cohort was 69 years (range, 47-89 years). Most of the patients (82.7%) had tumors with a GS of 6 or 7, 134 (21.6%) had PC with a GS of 3 + 4, 126 (20.4%) had PC with a GS of 4 + 3, and only 9% had clinical nodal metastasis. The median follow-up time for the entire cohort was 68.5 months (95% CI, 64.4-72.6 months). The 5-year FFBF, PFS, and PCSS rates were 93.2%, 83.2%, and 98.6%, respectively. They were predicted by the serum prostate specific antigen (PSA), Gleason score (GS), clinical nodal stage, and D'Amico risk group. Only 45 patients (7.3%) developed disease recurrence 41.9 months after RT. Of these patients, 12 (1.9% of the total) had BF only, 31 (5.3%) had both BF and distant metastasis, and 2 (0.3%) had distant metastasis only. The 5-year FFBF rates for low-, intermediate-, and high-risk disease were 98.0%, 93.1%, and 88.5%, respectively (p < 0.001). The 5-year PFS and PCSS rates according to risk groups were 91.0%, 82.1%, and 77.4% (p < 0.001), and 99.2%, 96.4%, and 95.9% (p = 0.03), and respectively. GS > 7 and lymph node metastasis negatively predicted FFBF and PCSS in multivariable analysis. Lymph node metastasis was associated with poor PFS, but only marginally (p = 0.06). Ninety (14.6%) and 44 (7.1%) patients had acute Grade ≥ 2 GU and GI toxicities, respectively, and 42 (6.8%) and 27 (4.4%) patients had late Grade ≥ 2 GU and GI toxicities, respectively. Diabetes (OR = 2.61; 95% CI = 1.29-5.26; p = 0.007) and transurethral resection of prostate (OR = 6.75; 95% CI = 3.37-13.54; p = 0.001) independently predicted late Grade ≥ 2 GU toxicity, but no significant predictor of late Grade ≥ 2 GI toxicity was found.Localized PC was effectively and safely treated with definitive RT using the SIB technique to deliver 86 Gy to the IPL in 39 fractions without severe late toxicity. This finding must be validated with long-term results." @default.
• W4387206989 created "2023-09-30" @default.
• W4387206989 creator A5008454988 @default.
• W4387206989 creator A5044546150 @default.
• W4387206989 creator A5057528579 @default.
• W4387206989 creator A5058361870 @default.
• W4387206989 creator A5070958553 @default.
• W4387206989 date "2023-10-01" @default.
• W4387206989 modified "2023-10-17" @default.
• W4387206989 title "Treatment Outcomes of Simultaneous Integrated Boost to Intraprostatic Lesions with External Beam Radiotherapy in Localized Prostate Cancer Patients" @default.
• W4387206989 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1584" @default.
• W4387206989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37785393" @default.
• W4387206989 hasPublicationYear "2023" @default.
• W4387206989 type Work @default.
• W4387206989 citedByCount "0" @default.
• W4387206989 crossrefType "journal-article" @default.
• W4387206989 hasAuthorship W4387206989A5008454988 @default.
• W4387206989 hasAuthorship W4387206989A5044546150 @default.
• W4387206989 hasAuthorship W4387206989A5057528579 @default.
• W4387206989 hasAuthorship W4387206989A5058361870 @default.
• W4387206989 hasAuthorship W4387206989A5070958553 @default.
• W4387206989 hasConcept C121608353 @default.
• W4387206989 hasConcept C126322002 @default.
• W4387206989 hasConcept C126894567 @default.
• W4387206989 hasConcept C133507102 @default.
• W4387206989 hasConcept C143998085 @default.
• W4387206989 hasConcept C146357865 @default.
• W4387206989 hasConcept C151730666 @default.
• W4387206989 hasConcept C2775908122 @default.
• W4387206989 hasConcept C2776235491 @default.
• W4387206989 hasConcept C2779013556 @default.
• W4387206989 hasConcept C2780192828 @default.
• W4387206989 hasConcept C2781406297 @default.
• W4387206989 hasConcept C509974204 @default.
• W4387206989 hasConcept C71924100 @default.
• W4387206989 hasConcept C72563966 @default.
• W4387206989 hasConcept C86803240 @default.
• W4387206989 hasConceptScore W4387206989C121608353 @default.
• W4387206989 hasConceptScore W4387206989C126322002 @default.
• W4387206989 hasConceptScore W4387206989C126894567 @default.
• W4387206989 hasConceptScore W4387206989C133507102 @default.
• W4387206989 hasConceptScore W4387206989C143998085 @default.
• W4387206989 hasConceptScore W4387206989C146357865 @default.
• W4387206989 hasConceptScore W4387206989C151730666 @default.
• W4387206989 hasConceptScore W4387206989C2775908122 @default.
• W4387206989 hasConceptScore W4387206989C2776235491 @default.
• W4387206989 hasConceptScore W4387206989C2779013556 @default.
• W4387206989 hasConceptScore W4387206989C2780192828 @default.
• W4387206989 hasConceptScore W4387206989C2781406297 @default.
• W4387206989 hasConceptScore W4387206989C509974204 @default.
• W4387206989 hasConceptScore W4387206989C71924100 @default.
• W4387206989 hasConceptScore W4387206989C72563966 @default.
• W4387206989 hasConceptScore W4387206989C86803240 @default.
• W4387206989 hasIssue "2" @default.
• W4387206989 hasLocation W43872069891 @default.
• W4387206989 hasLocation W43872069892 @default.
• W4387206989 hasOpenAccess W4387206989 @default.
• W4387206989 hasPrimaryLocation W43872069891 @default.
• W4387206989 hasRelatedWork W1980188241 @default.
• W4387206989 hasRelatedWork W1992657261 @default.
• W4387206989 hasRelatedWork W2038565121 @default.
• W4387206989 hasRelatedWork W2148869351 @default.
• W4387206989 hasRelatedWork W2373651588 @default.
• W4387206989 hasRelatedWork W2897445903 @default.
• W4387206989 hasRelatedWork W2944341298 @default.
• W4387206989 hasRelatedWork W3129209394 @default.
• W4387206989 hasRelatedWork W3163649103 @default.
• W4387206989 hasRelatedWork W4281788288 @default.
• W4387206989 hasVolume "117" @default.
• W4387206989 isParatext "false" @default.
• W4387206989 isRetracted "false" @default.
• W4387206989 workType "article" @default.