Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387207025> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4387207025 endingPage "e499" @default.
- W4387207025 startingPage "e499" @default.
- W4387207025 abstract "Brentuximab vedotin (BV) and immune checkpoint inhibitors (ICIs) had important roles in the treatment of relapse or refractory (R/R) Hodgkin lymphoma (HL). Treatment of refractory disease after BV and -/or ICIs remains a challenge. This study was conducted to evaluate the efficacy and safety of radiotherapy for R/R HL after failure to BV or ICIs.We retrospectively analyzed patients in two institutions with R/R HL who had failed after first-line therapy, and were refractory to BV or ICIs, and received radiotherapy (RT) thereafter. The overall response rate (ORR), duration of response (DOR), progression-free survival (PFS) and overall survival (OS) were analyzed.A total of 19 patients were enrolled. First-line systemic therapy consisted of ABVD (84.2%), AVD + ICIs (10.5%) and BEACOPP (5.3%), respectively. After first-line therapy, 15 patients (78.9%) were refractory, and 4 patients (21.1%) relapsed. After diagnosis of R/R HL, 8 patients (42.1%) received BV, and 17 patients (89.5%) received ICIs. RT was delivered in all 19 patients who failed after BV or ICIs. In 16 efficacy-evaluable patients, the ORR and CR rate were 100% and 100%. The median DOR was 17.2 months (range, 7.9 to 46.7 months). 3 patients progressed at outside of the radiation field. The in-field-response rate was 100%. The 12-month PFS and OS were 84.4% and 100%, respectively. No patients were reported with sever adverse events.This study concluded that radiotherapy was effective and safe for refractory HL after BV or ICIs. Further prospective studies were warranted." @default.
- W4387207025 created "2023-09-30" @default.
- W4387207025 creator A5001508669 @default.
- W4387207025 creator A5010479652 @default.
- W4387207025 creator A5012119333 @default.
- W4387207025 creator A5016013697 @default.
- W4387207025 creator A5021294207 @default.
- W4387207025 creator A5025087223 @default.
- W4387207025 creator A5027398243 @default.
- W4387207025 creator A5031030286 @default.
- W4387207025 creator A5035282947 @default.
- W4387207025 creator A5038545320 @default.
- W4387207025 creator A5048879163 @default.
- W4387207025 creator A5065479590 @default.
- W4387207025 creator A5076038162 @default.
- W4387207025 creator A5077293966 @default.
- W4387207025 creator A5086714131 @default.
- W4387207025 creator A5087585454 @default.
- W4387207025 creator A5090376184 @default.
- W4387207025 date "2023-10-01" @default.
- W4387207025 modified "2023-10-18" @default.
- W4387207025 title "The Role of Radiotherapy in Patients with Refractory Hodgkin Lymphoma after Brentuximab Vedotin and -/or Immune Checkpoint Inhibitors" @default.
- W4387207025 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1741" @default.
- W4387207025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37785568" @default.
- W4387207025 hasPublicationYear "2023" @default.
- W4387207025 type Work @default.
- W4387207025 citedByCount "0" @default.
- W4387207025 crossrefType "journal-article" @default.
- W4387207025 hasAuthorship W4387207025A5001508669 @default.
- W4387207025 hasAuthorship W4387207025A5010479652 @default.
- W4387207025 hasAuthorship W4387207025A5012119333 @default.
- W4387207025 hasAuthorship W4387207025A5016013697 @default.
- W4387207025 hasAuthorship W4387207025A5021294207 @default.
- W4387207025 hasAuthorship W4387207025A5025087223 @default.
- W4387207025 hasAuthorship W4387207025A5027398243 @default.
- W4387207025 hasAuthorship W4387207025A5031030286 @default.
- W4387207025 hasAuthorship W4387207025A5035282947 @default.
- W4387207025 hasAuthorship W4387207025A5038545320 @default.
- W4387207025 hasAuthorship W4387207025A5048879163 @default.
- W4387207025 hasAuthorship W4387207025A5065479590 @default.
- W4387207025 hasAuthorship W4387207025A5076038162 @default.
- W4387207025 hasAuthorship W4387207025A5077293966 @default.
- W4387207025 hasAuthorship W4387207025A5086714131 @default.
- W4387207025 hasAuthorship W4387207025A5087585454 @default.
- W4387207025 hasAuthorship W4387207025A5090376184 @default.
- W4387207025 hasConcept C121332964 @default.
- W4387207025 hasConcept C126322002 @default.
- W4387207025 hasConcept C142424586 @default.
- W4387207025 hasConcept C143998085 @default.
- W4387207025 hasConcept C197934379 @default.
- W4387207025 hasConcept C2776305933 @default.
- W4387207025 hasConcept C2776694085 @default.
- W4387207025 hasConcept C2776755627 @default.
- W4387207025 hasConcept C2778191690 @default.
- W4387207025 hasConcept C2779338263 @default.
- W4387207025 hasConcept C2779429289 @default.
- W4387207025 hasConcept C2992779791 @default.
- W4387207025 hasConcept C509974204 @default.
- W4387207025 hasConcept C71924100 @default.
- W4387207025 hasConcept C87355193 @default.
- W4387207025 hasConcept C90924648 @default.
- W4387207025 hasConceptScore W4387207025C121332964 @default.
- W4387207025 hasConceptScore W4387207025C126322002 @default.
- W4387207025 hasConceptScore W4387207025C142424586 @default.
- W4387207025 hasConceptScore W4387207025C143998085 @default.
- W4387207025 hasConceptScore W4387207025C197934379 @default.
- W4387207025 hasConceptScore W4387207025C2776305933 @default.
- W4387207025 hasConceptScore W4387207025C2776694085 @default.
- W4387207025 hasConceptScore W4387207025C2776755627 @default.
- W4387207025 hasConceptScore W4387207025C2778191690 @default.
- W4387207025 hasConceptScore W4387207025C2779338263 @default.
- W4387207025 hasConceptScore W4387207025C2779429289 @default.
- W4387207025 hasConceptScore W4387207025C2992779791 @default.
- W4387207025 hasConceptScore W4387207025C509974204 @default.
- W4387207025 hasConceptScore W4387207025C71924100 @default.
- W4387207025 hasConceptScore W4387207025C87355193 @default.
- W4387207025 hasConceptScore W4387207025C90924648 @default.
- W4387207025 hasIssue "2" @default.
- W4387207025 hasLocation W43872070251 @default.
- W4387207025 hasLocation W43872070252 @default.
- W4387207025 hasOpenAccess W4387207025 @default.
- W4387207025 hasPrimaryLocation W43872070251 @default.
- W4387207025 hasRelatedWork W2017023812 @default.
- W4387207025 hasRelatedWork W2112851763 @default.
- W4387207025 hasRelatedWork W2293179614 @default.
- W4387207025 hasRelatedWork W2405509401 @default.
- W4387207025 hasRelatedWork W2417555288 @default.
- W4387207025 hasRelatedWork W2587060062 @default.
- W4387207025 hasRelatedWork W2751234571 @default.
- W4387207025 hasRelatedWork W2891182120 @default.
- W4387207025 hasRelatedWork W3021548126 @default.
- W4387207025 hasRelatedWork W4290436003 @default.
- W4387207025 hasVolume "117" @default.
- W4387207025 isParatext "false" @default.
- W4387207025 isRetracted "false" @default.
- W4387207025 workType "article" @default.