FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387207166> ?p ?o ?g. }

• W4387207166 endingPage "e723" @default.
• W4387207166 startingPage "e722" @default.
• W4387207166 abstract "A Biology-guided Radiotherapy (BgRT) based device is designed to use Positron Emission Tomography (PET) signals to achieve tracked dose delivery. The goal of this study is to investigate the dose delivery accuracy in case of interruption during BgRT treatment, and resumption in a separate treatment session for a multi-target delivery, as the PET activity continues to decay.A custom-built large anthropomorphic phantom (LAP) including a 26 mm spherical target with 3D independent motion and two 22 mm spherical targets with 1D sinusoidal motion embedded in water was used. All three targets were filled with FGD in an 8:1 target to background uptake ratio (41.52 kBq/ml in target and 5.19 kBq/ml in background). During BgRT delivery, the treatment was intentionally paused during delivery to the second target and the current treatment session was ended to generate a partial fraction. Then the partial fraction was continued in a new session, where the CT scan localization and PET pre-scan were repeated using the existing PET activity present in the phantom. The newly acquired PET pre-scan, was then used to determine if sufficient PET counts were present to resume treatment delivery. The interruption and recovery algorithm is designed to calculate the fluence that needs to be delivered to the remaining targets as well as the residual fluence to be given to the targets that have already received partial dose prior to the interruption. Once the new fluence is recomputed, the treatment is resumed. The delivered doses were captured using radiochromic film (EBT-XD) inserted in the target as well as post-treatment dose calculations based on the delivered beamlet sequence to evaluate the results in terms of dosimetric coverage and margin loss. The margin loss is calculated as the maximum difference between the distance from the Clinical Target Volume (CTV) contour to the 97% isodose contour in the treatment plan and the on the film. The dosimetric coverage is defined as the percentage of voxels within the CTV that lies within 97% and 130% of the prescribed dose.As shown in the table below, a margin loss of less than 3 mm for all targets and 100% CTV coverage was achieved. After treatment interruptions, the PET safety evaluation based on the PET pre-scan helped to determine whether the treatment could be continued on the same day using the same injected PET activity (an NTS value ≧ 2 and AC value ≧ 5 kBq/ml).This study demonstrated that the BgRT system is able to deliver the prescribed dose to all targets with independent motion, even when an interruption and resumption occurs during treatment. In case such an interruption if the remaining PET activity satisfies the BgRT safety evaluation, the treatment can continue to deliver the remainder of the BgRT doses." @default.
• W4387207166 created "2023-09-30" @default.
• W4387207166 creator A5008135017 @default.
• W4387207166 creator A5018248168 @default.
• W4387207166 creator A5019242492 @default.
• W4387207166 creator A5027865558 @default.
• W4387207166 creator A5031290100 @default.
• W4387207166 creator A5050255780 @default.
• W4387207166 creator A5051230284 @default.
• W4387207166 creator A5057829345 @default.
• W4387207166 creator A5074985368 @default.
• W4387207166 creator A5082747706 @default.
• W4387207166 date "2023-10-01" @default.
• W4387207166 modified "2023-10-17" @default.
• W4387207166 title "Evaluation of Treatment Interruptions and Recovery during Biology-Guided Radiotherapy Delivery" @default.
• W4387207166 doi "https://doi.org/10.1016/j.ijrobp.2023.06.2233" @default.
• W4387207166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37786107" @default.
• W4387207166 hasPublicationYear "2023" @default.
• W4387207166 type Work @default.
• W4387207166 citedByCount "0" @default.
• W4387207166 crossrefType "journal-article" @default.
• W4387207166 hasAuthorship W4387207166A5008135017 @default.
• W4387207166 hasAuthorship W4387207166A5018248168 @default.
• W4387207166 hasAuthorship W4387207166A5019242492 @default.
• W4387207166 hasAuthorship W4387207166A5027865558 @default.
• W4387207166 hasAuthorship W4387207166A5031290100 @default.
• W4387207166 hasAuthorship W4387207166A5050255780 @default.
• W4387207166 hasAuthorship W4387207166A5051230284 @default.
• W4387207166 hasAuthorship W4387207166A5057829345 @default.
• W4387207166 hasAuthorship W4387207166A5074985368 @default.
• W4387207166 hasAuthorship W4387207166A5082747706 @default.
• W4387207166 hasConcept C104293457 @default.
• W4387207166 hasConcept C111337013 @default.
• W4387207166 hasConcept C121332964 @default.
• W4387207166 hasConcept C126838900 @default.
• W4387207166 hasConcept C127077266 @default.
• W4387207166 hasConcept C136229726 @default.
• W4387207166 hasConcept C136764020 @default.
• W4387207166 hasConcept C185544564 @default.
• W4387207166 hasConcept C19527891 @default.
• W4387207166 hasConcept C22078206 @default.
• W4387207166 hasConcept C2775842073 @default.
• W4387207166 hasConcept C2779182362 @default.
• W4387207166 hasConcept C2989005 @default.
• W4387207166 hasConcept C3017724952 @default.
• W4387207166 hasConcept C41008148 @default.
• W4387207166 hasConcept C509974204 @default.
• W4387207166 hasConcept C71924100 @default.
• W4387207166 hasConceptScore W4387207166C104293457 @default.
• W4387207166 hasConceptScore W4387207166C111337013 @default.
• W4387207166 hasConceptScore W4387207166C121332964 @default.
• W4387207166 hasConceptScore W4387207166C126838900 @default.
• W4387207166 hasConceptScore W4387207166C127077266 @default.
• W4387207166 hasConceptScore W4387207166C136229726 @default.
• W4387207166 hasConceptScore W4387207166C136764020 @default.
• W4387207166 hasConceptScore W4387207166C185544564 @default.
• W4387207166 hasConceptScore W4387207166C19527891 @default.
• W4387207166 hasConceptScore W4387207166C22078206 @default.
• W4387207166 hasConceptScore W4387207166C2775842073 @default.
• W4387207166 hasConceptScore W4387207166C2779182362 @default.
• W4387207166 hasConceptScore W4387207166C2989005 @default.
• W4387207166 hasConceptScore W4387207166C3017724952 @default.
• W4387207166 hasConceptScore W4387207166C41008148 @default.
• W4387207166 hasConceptScore W4387207166C509974204 @default.
• W4387207166 hasConceptScore W4387207166C71924100 @default.
• W4387207166 hasIssue "2" @default.
• W4387207166 hasLocation W43872071661 @default.
• W4387207166 hasLocation W43872071662 @default.
• W4387207166 hasOpenAccess W4387207166 @default.
• W4387207166 hasPrimaryLocation W43872071661 @default.
• W4387207166 hasRelatedWork W1600760618 @default.
• W4387207166 hasRelatedWork W1987466798 @default.
• W4387207166 hasRelatedWork W1991553034 @default.
• W4387207166 hasRelatedWork W2065905577 @default.
• W4387207166 hasRelatedWork W2067600736 @default.
• W4387207166 hasRelatedWork W2152428561 @default.
• W4387207166 hasRelatedWork W2409755182 @default.
• W4387207166 hasRelatedWork W2750234910 @default.
• W4387207166 hasRelatedWork W284644260 @default.
• W4387207166 hasRelatedWork W4311699937 @default.
• W4387207166 hasVolume "117" @default.
• W4387207166 isParatext "false" @default.
• W4387207166 isRetracted "false" @default.
• W4387207166 workType "article" @default.