FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387207616> ?p ?o ?g. }

• W4387207616 endingPage "e319" @default.
• W4387207616 startingPage "e319" @default.
• W4387207616 abstract "The clinical significance of radiographic progression during pre-operative radiation therapy (RT) for soft tissue sarcoma (STS) remains unclear. We sought to evaluate associations between radiographic change on T1 post-contrast (T1c) and T2 weighted magnetic resonance imaging (MRI) with percent pathological response (PR%), positive surgical margins (+SM), and local control (LC).We retrospectively identified patients with STS undergoing neoadjuvant RT who had both pre- and post-RT MRI prior to surgical resection. Gross tumor volumes were contoured on pre- and post-RT T1c and T2 MRI sequences and relative change in volume from baseline was calculated. Radiographic classification was defined as response (>30% reduction), progression (>30% increase), or stable (≤30% reduction or ≤30% increase). Chi squared, Fishers Exact, and Kruskal Wallis (KW) tests were used to assess differences between groups. Linear and binary logistic regression models used to assess associations between MRI response and PR% and +SM, respectively. LC was modeled with Kaplan Meier methods and log rank tests.A total of 68 STS patients were identified, with a median follow up of 49 months (range 7-229). With a median age of 60.5 years (25-88) and tumor size of 10.8cm (2.7-25.7), the most common histologies were undifferentiated pleomorphic sarcoma (UPS; 32.4%) and myxoid liposarcoma (ML; 16.2%), and were primarily grade 2-3 disease (89.7%). With a median RT dose of 50 Gy in 25 fractions (44-60Gy), the median radiographic volume change was 2% (-86.4 to 953.6%) and -2.1% (-89.6 to 962.5%) for T1c and T2, respectively. Radiographic classification of response/stable/progression was 25.4%/49.2%/25.4% and 27.9%/52.5%/19.7% for T1c and T2, respectively. Histology (ML vs. UPS) and grade (1 vs. 3) were predictors for radiographic response on both T1c (72.7% vs 18.8%, p = 0.03 and 71.4% vs. 10.4%, p = 0.03) and T2 (71.5% vs. 18.2%, p = 0.02 and 71.4% vs. 14.6%, p = 0.002), respectively. With 6 +SM (8.8%), the rate of +SM for response/stable/progression was 20%/10.3%/0% in T1c (p = 0.2) and 5.9%/12.5%/0% in T2 (p = 0.5). As a continuous variable, neither relative change on T1c (p = 0.2) or T2 (p = 0.4) were associated with +SM. With an overall median PR% of 64% (0-100%), the median PR% was significantly different for response/stable/progression for both T1c (95%/42%/73%, p = 0.02) and T2 (95%/50%/87.5%, p = 0.04). Radiographic change on neither T1c (p = 0.4) or T2 (p = 0.5) were associated with PR% on a continuous basis. With a total of 4 local recurrences, there was no significant difference in LC by radiographic classification on either T1c (p = 0.65) or T2 (p = 0.85).While radiographic response may be correlated with pathological response, radiographic progression on either T1c or T2 following neoadjuvant RT was not associated with a detriment in surgical margins or local control. These findings suggest that STS radiographic pseudoprogression is not associated with worse outcome." @default.
• W4387207616 created "2023-09-30" @default.
• W4387207616 creator A5018847418 @default.
• W4387207616 creator A5043293845 @default.
• W4387207616 creator A5047495544 @default.
• W4387207616 creator A5052789258 @default.
• W4387207616 creator A5056978062 @default.
• W4387207616 creator A5080432330 @default.
• W4387207616 creator A5083179915 @default.
• W4387207616 date "2023-10-01" @default.
• W4387207616 modified "2023-10-17" @default.
• W4387207616 title "Association between Tumor Volume Change on MRI with Surgical Margin Status, Pathological Response, and Local Control Following Pre-Operative Radiation Therapy for Soft Tissue Sarcoma" @default.
• W4387207616 doi "https://doi.org/10.1016/j.ijrobp.2023.06.2356" @default.
• W4387207616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37785142" @default.
• W4387207616 hasPublicationYear "2023" @default.
• W4387207616 type Work @default.
• W4387207616 citedByCount "0" @default.
• W4387207616 crossrefType "journal-article" @default.
• W4387207616 hasAuthorship W4387207616A5018847418 @default.
• W4387207616 hasAuthorship W4387207616A5043293845 @default.
• W4387207616 hasAuthorship W4387207616A5047495544 @default.
• W4387207616 hasAuthorship W4387207616A5052789258 @default.
• W4387207616 hasAuthorship W4387207616A5056978062 @default.
• W4387207616 hasAuthorship W4387207616A5080432330 @default.
• W4387207616 hasAuthorship W4387207616A5083179915 @default.
• W4387207616 hasConcept C121608353 @default.
• W4387207616 hasConcept C126322002 @default.
• W4387207616 hasConcept C126838900 @default.
• W4387207616 hasConcept C136948725 @default.
• W4387207616 hasConcept C142724271 @default.
• W4387207616 hasConcept C143409427 @default.
• W4387207616 hasConcept C207886595 @default.
• W4387207616 hasConcept C2778256501 @default.
• W4387207616 hasConcept C2778629024 @default.
• W4387207616 hasConcept C2778913397 @default.
• W4387207616 hasConcept C2779568860 @default.
• W4387207616 hasConcept C2989005 @default.
• W4387207616 hasConcept C36454342 @default.
• W4387207616 hasConcept C509974204 @default.
• W4387207616 hasConcept C65409693 @default.
• W4387207616 hasConcept C71924100 @default.
• W4387207616 hasConceptScore W4387207616C121608353 @default.
• W4387207616 hasConceptScore W4387207616C126322002 @default.
• W4387207616 hasConceptScore W4387207616C126838900 @default.
• W4387207616 hasConceptScore W4387207616C136948725 @default.
• W4387207616 hasConceptScore W4387207616C142724271 @default.
• W4387207616 hasConceptScore W4387207616C143409427 @default.
• W4387207616 hasConceptScore W4387207616C207886595 @default.
• W4387207616 hasConceptScore W4387207616C2778256501 @default.
• W4387207616 hasConceptScore W4387207616C2778629024 @default.
• W4387207616 hasConceptScore W4387207616C2778913397 @default.
• W4387207616 hasConceptScore W4387207616C2779568860 @default.
• W4387207616 hasConceptScore W4387207616C2989005 @default.
• W4387207616 hasConceptScore W4387207616C36454342 @default.
• W4387207616 hasConceptScore W4387207616C509974204 @default.
• W4387207616 hasConceptScore W4387207616C65409693 @default.
• W4387207616 hasConceptScore W4387207616C71924100 @default.
• W4387207616 hasIssue "2" @default.
• W4387207616 hasLocation W43872076161 @default.
• W4387207616 hasLocation W43872076162 @default.
• W4387207616 hasOpenAccess W4387207616 @default.
• W4387207616 hasPrimaryLocation W43872076161 @default.
• W4387207616 hasRelatedWork W1964112796 @default.
• W4387207616 hasRelatedWork W1978776472 @default.
• W4387207616 hasRelatedWork W1981313983 @default.
• W4387207616 hasRelatedWork W2235561576 @default.
• W4387207616 hasRelatedWork W2318845186 @default.
• W4387207616 hasRelatedWork W2409094465 @default.
• W4387207616 hasRelatedWork W2483326396 @default.
• W4387207616 hasRelatedWork W2582193742 @default.
• W4387207616 hasRelatedWork W3164086790 @default.
• W4387207616 hasRelatedWork W4232811572 @default.
• W4387207616 hasVolume "117" @default.
• W4387207616 isParatext "false" @default.
• W4387207616 isRetracted "false" @default.
• W4387207616 workType "article" @default.