FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387207624> ?p ?o ?g. }

• W4387207624 endingPage "e352" @default.
• W4387207624 startingPage "e351" @default.
• W4387207624 abstract "A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology (JASTRO) in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis of esophagogastric cancers.Cases in which PBT was performed at all PBT facilities in Japan between May 2016 and February 2019 were enrolled. The patients were selected based on the following criteria: controlled primary cancer; liver recurrence without extrahepatic tumors; and no more than three liver lesions. The dose and fraction of PBT were determined using unified treatment policy established by JASTRO. We used the following protocol, 64 gray (relative biological effect) (Gy (RBE))/8 fractions (fr) for the peripheral region, and 72.6 GyE/22fr for the central region. For safety aspect, the hepatocellular carcinoma irradiation protocols of 66 Gy (RBE)/10fr, 72.6-76 Gy (RBE)/20-22fr, and 74-76 Gy (RBE)/37-38fr could be allowed. The overall survival (OS), local control (LC), and adverse events (AEs) were examined. The OS and LC rates were calculated using the Kaplan-Meier method. Factors possibly related to OS, such as tumor size (for multiple lesions, the largest size), number of liver tumors, as well as the presence or absence of prior, concurrent, and post-PBT chemotherapy, were investigated. The cut-off values were estimated using the receiver operating characteristic curve and area under the curve. Univariate analysis was performed using the log-rank test. Statistical significance was P-values < 0.05.Twenty-three males and two females with a median age of 69 (range, 52-80) years and 36 lesions were included. This study included six patients with esophageal and 19 patients with gastric cancer. The median lesion size, fraction size, and biological effective dose (BED)10 were 31 (7-104) mm, 3.8 gray (relative biological effect)/fractions (Gy (RBE)/fr) (2-8 Gy (RBE)/fr), and 96.9 (88.8-115.2) Gy, respectively. The median follow-up period was 18 (4-47) months. The 1-, 2-, and 3-year OS rates were 76.0, 49.5, and 43.3%, respectively, and the median OS was 19 months. The 1-, 2-, and 3-year OS rates of esophageal cancer were 83.3% for all. The 1-, 2-, and 3-year OS rates of gastric cancer were 73.7, 40.2, and 32.2%, respectively, and the median OS was 18 months. The 1-, 2-, and 3-year LC rates were 96.3, 91.5, and 91.5%, respectively. The 1-, 2-, and 3-year LC rates of esophageal cancer were 100% for all. The 1-, 2-, and 3-year LC rates of gastric cancers were 94.7, 88.0, and 88.0%, respectively. Tumor size was the only significant OS-related factor (P < 0.01). No grade 3 or higher adverse events were observed.Owing to the low incidence of adverse events and the high LC rate, PBT is a feasible option for liver oligometastasis of esophagogastric cancers." @default.
• W4387207624 created "2023-09-30" @default.
• W4387207624 creator A5011553863 @default.
• W4387207624 creator A5020793018 @default.
• W4387207624 creator A5024656865 @default.
• W4387207624 creator A5051227977 @default.
• W4387207624 creator A5072388082 @default.
• W4387207624 creator A5085477743 @default.
• W4387207624 creator A5091639568 @default.
• W4387207624 date "2023-10-01" @default.
• W4387207624 modified "2023-10-17" @default.
• W4387207624 title "The Japanese Nationwide Cohort Data of Particle Beam Therapy for Liver Oligometastasis in Esophagogastric Cancer Patients" @default.
• W4387207624 doi "https://doi.org/10.1016/j.ijrobp.2023.06.2427" @default.
• W4387207624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37785217" @default.
• W4387207624 hasPublicationYear "2023" @default.
• W4387207624 type Work @default.
• W4387207624 citedByCount "0" @default.
• W4387207624 crossrefType "journal-article" @default.
• W4387207624 hasAuthorship W4387207624A5011553863 @default.
• W4387207624 hasAuthorship W4387207624A5020793018 @default.
• W4387207624 hasAuthorship W4387207624A5024656865 @default.
• W4387207624 hasAuthorship W4387207624A5051227977 @default.
• W4387207624 hasAuthorship W4387207624A5072388082 @default.
• W4387207624 hasAuthorship W4387207624A5085477743 @default.
• W4387207624 hasAuthorship W4387207624A5091639568 @default.
• W4387207624 hasConcept C121608353 @default.
• W4387207624 hasConcept C126322002 @default.
• W4387207624 hasConcept C143998085 @default.
• W4387207624 hasConcept C144301174 @default.
• W4387207624 hasConcept C197934379 @default.
• W4387207624 hasConcept C2776231280 @default.
• W4387207624 hasConcept C2778019345 @default.
• W4387207624 hasConcept C2989005 @default.
• W4387207624 hasConcept C38180746 @default.
• W4387207624 hasConcept C509974204 @default.
• W4387207624 hasConcept C71924100 @default.
• W4387207624 hasConcept C72563966 @default.
• W4387207624 hasConcept C90924648 @default.
• W4387207624 hasConceptScore W4387207624C121608353 @default.
• W4387207624 hasConceptScore W4387207624C126322002 @default.
• W4387207624 hasConceptScore W4387207624C143998085 @default.
• W4387207624 hasConceptScore W4387207624C144301174 @default.
• W4387207624 hasConceptScore W4387207624C197934379 @default.
• W4387207624 hasConceptScore W4387207624C2776231280 @default.
• W4387207624 hasConceptScore W4387207624C2778019345 @default.
• W4387207624 hasConceptScore W4387207624C2989005 @default.
• W4387207624 hasConceptScore W4387207624C38180746 @default.
• W4387207624 hasConceptScore W4387207624C509974204 @default.
• W4387207624 hasConceptScore W4387207624C71924100 @default.
• W4387207624 hasConceptScore W4387207624C72563966 @default.
• W4387207624 hasConceptScore W4387207624C90924648 @default.
• W4387207624 hasIssue "2" @default.
• W4387207624 hasLocation W43872076241 @default.
• W4387207624 hasLocation W43872076242 @default.
• W4387207624 hasOpenAccess W4387207624 @default.
• W4387207624 hasPrimaryLocation W43872076241 @default.
• W4387207624 hasRelatedWork W2378315152 @default.
• W4387207624 hasRelatedWork W2384708512 @default.
• W4387207624 hasRelatedWork W2396739986 @default.
• W4387207624 hasRelatedWork W2603773853 @default.
• W4387207624 hasRelatedWork W2766588635 @default.
• W4387207624 hasRelatedWork W3009075395 @default.
• W4387207624 hasRelatedWork W3030616408 @default.
• W4387207624 hasRelatedWork W3032416622 @default.
• W4387207624 hasRelatedWork W3083338011 @default.
• W4387207624 hasRelatedWork W4235542796 @default.
• W4387207624 hasVolume "117" @default.
• W4387207624 isParatext "false" @default.
• W4387207624 isRetracted "false" @default.
• W4387207624 workType "article" @default.