FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387207680> ?p ?o ?g. }

• W4387207680 endingPage "113187" @default.
• W4387207680 startingPage "113187" @default.
• W4387207680 abstract "Early-life stress and ovarian hormones contribute to increased female vulnerability to cocaine addiction. Here, we reveal molecular substrates in the reward area, the nucleus accumbens, through which these female-specific factors affect immediate and conditioning responses to cocaine. We find shared involvement of X chromosome inactivation-related and estrogen signaling-related gene regulation in enhanced conditioning responses following early-life stress and during the low-estrogenic state in females. Low-estrogenic females respond to acute cocaine by opening neuronal chromatin enriched for the sites of ΔFosB, a transcription factor implicated in chronic cocaine response and addiction. Conversely, high-estrogenic females respond to cocaine by preferential chromatin closing, providing a mechanism for limiting cocaine-driven chromatin and synaptic plasticity. We find that physiological estrogen withdrawal, early-life stress, and absence of one X chromosome all nullify the protective effect of a high-estrogenic state on cocaine conditioning in females. Our findings offer a molecular framework to enable understanding of sex-specific neuronal mechanisms underlying cocaine use disorder." @default.
• W4387207680 created "2023-09-30" @default.
• W4387207680 creator A5040370543 @default.
• W4387207680 creator A5048308048 @default.
• W4387207680 creator A5048839844 @default.
• W4387207680 creator A5052594738 @default.
• W4387207680 creator A5066911367 @default.
• W4387207680 creator A5067381939 @default.
• W4387207680 creator A5089796357 @default.
• W4387207680 date "2023-10-01" @default.
• W4387207680 modified "2023-10-18" @default.
• W4387207680 title "Early-life stress and ovarian hormones alter transcriptional regulation in the nucleus accumbens resulting in sex-specific responses to cocaine" @default.
• W4387207680 cites W1487599137 @default.
• W4387207680 cites W1959245327 @default.
• W4387207680 cites W1964374986 @default.
• W4387207680 cites W1968179768 @default.
• W4387207680 cites W1977419289 @default.
• W4387207680 cites W1979956204 @default.
• W4387207680 cites W1983069416 @default.
• W4387207680 cites W1991223384 @default.
• W4387207680 cites W2000696407 @default.
• W4387207680 cites W2004847334 @default.
• W4387207680 cites W2014677321 @default.
• W4387207680 cites W2015556634 @default.
• W4387207680 cites W2029087061 @default.
• W4387207680 cites W2029262422 @default.
• W4387207680 cites W2031435056 @default.
• W4387207680 cites W2035616108 @default.
• W4387207680 cites W2040909468 @default.
• W4387207680 cites W2042372462 @default.
• W4387207680 cites W2042714786 @default.
• W4387207680 cites W2049672698 @default.
• W4387207680 cites W2051824629 @default.
• W4387207680 cites W2054545874 @default.
• W4387207680 cites W2057607875 @default.
• W4387207680 cites W2067762272 @default.
• W4387207680 cites W2070019933 @default.
• W4387207680 cites W2073198325 @default.
• W4387207680 cites W2073997424 @default.
• W4387207680 cites W2075527287 @default.
• W4387207680 cites W2076732852 @default.
• W4387207680 cites W2077231388 @default.
• W4387207680 cites W2077706363 @default.
• W4387207680 cites W2078160165 @default.
• W4387207680 cites W2080585999 @default.
• W4387207680 cites W2081427205 @default.
• W4387207680 cites W2083263207 @default.
• W4387207680 cites W2088450404 @default.
• W4387207680 cites W2097948046 @default.
• W4387207680 cites W2099082142 @default.
• W4387207680 cites W2103252476 @default.
• W4387207680 cites W2115155925 @default.
• W4387207680 cites W2117757143 @default.
• W4387207680 cites W2118812779 @default.
• W4387207680 cites W2123884188 @default.
• W4387207680 cites W2130410032 @default.
• W4387207680 cites W2131306683 @default.
• W4387207680 cites W2135302954 @default.
• W4387207680 cites W2135810615 @default.
• W4387207680 cites W2136482257 @default.
• W4387207680 cites W2137720632 @default.
• W4387207680 cites W2142790764 @default.
• W4387207680 cites W2145087065 @default.
• W4387207680 cites W2149627698 @default.
• W4387207680 cites W2150557642 @default.
• W4387207680 cites W2154182432 @default.
• W4387207680 cites W2156322627 @default.
• W4387207680 cites W2158034397 @default.
• W4387207680 cites W2158995449 @default.
• W4387207680 cites W2159675211 @default.
• W4387207680 cites W2161579926 @default.
• W4387207680 cites W2165155762 @default.
• W4387207680 cites W2166162210 @default.
• W4387207680 cites W2166372248 @default.
• W4387207680 cites W2166542841 @default.
• W4387207680 cites W2169456326 @default.
• W4387207680 cites W2169691228 @default.
• W4387207680 cites W2179438025 @default.
• W4387207680 cites W2255270868 @default.
• W4387207680 cites W2293676523 @default.
• W4387207680 cites W2426968778 @default.
• W4387207680 cites W2509465044 @default.
• W4387207680 cites W2520003619 @default.
• W4387207680 cites W2551050667 @default.
• W4387207680 cites W2570893979 @default.
• W4387207680 cites W2765114110 @default.
• W4387207680 cites W2776119327 @default.
• W4387207680 cites W2806359197 @default.
• W4387207680 cites W2807788357 @default.
• W4387207680 cites W2808013179 @default.
• W4387207680 cites W2809748547 @default.
• W4387207680 cites W2900962132 @default.
• W4387207680 cites W2922368534 @default.
• W4387207680 cites W2922422632 @default.
• W4387207680 cites W2923723239 @default.
• W4387207680 cites W2931032935 @default.
• W4387207680 cites W2944545583 @default.
• W4387207680 cites W2950464315 @default.

• next