FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387207894> ?p ?o ?g. }

• W4387207894 endingPage "146" @default.
• W4387207894 startingPage "136" @default.
• W4387207894 abstract "One of the major reasons behind the limited success of vaccine candidates against all forms of leishmaniasis is the inability of parasitic antigens to induce robust cell-mediated immunity and immunological memory. Here we find, for the first time, that the adjuvantation of whole-killed Leishmania vaccine (Leishvacc) with anti-CD200 and anti-CD300a antibodies enhances CD4+ T cells mediated immunity in vaccinated mice and provides protection against wild-type parasites. The antibody adjuvantation, either alone or with a TLR4 agonist monophosphoryl A (MPL-A), induced the production of pro-inflammatory cytokines viz., IFN-γ, TNF-α, and IL-2 by antigen experienced CD4+ T cells, and also enhanced their rate of conversion into their memory phenotypes against Leishvacc antigens. The antibody adjuvanted vaccine also promoted the generation of IgG2a-mediated protective humoral immunity in vaccinated mice. Further, the mice vaccinated with antibodies adjuvanted vaccine showed strong resilience against metacyclic forms of L. donovani parasites as we observed reduced clinical features such as splenomegaly, hepatomegaly, granulomatous tissues in the liver, and parasitic load in their spleen. The findings of this study demonstrate that the anti-CD200 and anti-CD300a antibodies have potential to increase the protective efficacy of the whole-killed Leishmania vaccine, and opens up a new gateway to diversify the roles of immune checkpoints in vaccine development against leishmaniasis." @default.
• W4387207894 created "2023-09-30" @default.
• W4387207894 creator A5015943062 @default.
• W4387207894 creator A5019196752 @default.
• W4387207894 creator A5022295407 @default.
• W4387207894 creator A5029743510 @default.
• W4387207894 creator A5038306575 @default.
• W4387207894 creator A5042453830 @default.
• W4387207894 creator A5071115755 @default.
• W4387207894 creator A5083176889 @default.
• W4387207894 creator A5083820454 @default.
• W4387207894 creator A5085711857 @default.
• W4387207894 date "2023-11-01" @default.
• W4387207894 modified "2023-10-03" @default.
• W4387207894 title "Adjuvantation of whole-killed Leishmania vaccine with anti-CD200 and anti-CD300a antibodies potentiates its efficacy and provides protection against wild-type parasites" @default.
• W4387207894 cites W1540820582 @default.
• W4387207894 cites W1916951947 @default.
• W4387207894 cites W1949307585 @default.
• W4387207894 cites W1972018312 @default.
• W4387207894 cites W1974433492 @default.
• W4387207894 cites W1974485086 @default.
• W4387207894 cites W1977589642 @default.
• W4387207894 cites W1994879603 @default.
• W4387207894 cites W2008244249 @default.
• W4387207894 cites W2021373422 @default.
• W4387207894 cites W2034866848 @default.
• W4387207894 cites W2038850624 @default.
• W4387207894 cites W2043819612 @default.
• W4387207894 cites W2043832228 @default.
• W4387207894 cites W2050503449 @default.
• W4387207894 cites W2062016511 @default.
• W4387207894 cites W2074195357 @default.
• W4387207894 cites W2080420789 @default.
• W4387207894 cites W2086879443 @default.
• W4387207894 cites W2097779502 @default.
• W4387207894 cites W2097995306 @default.
• W4387207894 cites W2099636172 @default.
• W4387207894 cites W2103239817 @default.
• W4387207894 cites W2114918609 @default.
• W4387207894 cites W2135360970 @default.
• W4387207894 cites W2143242765 @default.
• W4387207894 cites W2148044949 @default.
• W4387207894 cites W2148706578 @default.
• W4387207894 cites W2151440062 @default.
• W4387207894 cites W2166332777 @default.
• W4387207894 cites W2170904230 @default.
• W4387207894 cites W2171371924 @default.
• W4387207894 cites W2280058722 @default.
• W4387207894 cites W2293820371 @default.
• W4387207894 cites W2385321340 @default.
• W4387207894 cites W2613163210 @default.
• W4387207894 cites W2770374950 @default.
• W4387207894 cites W2777159454 @default.
• W4387207894 cites W2799706874 @default.
• W4387207894 cites W2916153257 @default.
• W4387207894 cites W2945590213 @default.
• W4387207894 cites W2946033191 @default.
• W4387207894 cites W2962115187 @default.
• W4387207894 cites W2965509953 @default.
• W4387207894 cites W2980449436 @default.
• W4387207894 cites W2999958881 @default.
• W4387207894 cites W3008840156 @default.
• W4387207894 cites W3091505034 @default.
• W4387207894 cites W3185428150 @default.
• W4387207894 cites W3210000746 @default.
• W4387207894 cites W3210650642 @default.
• W4387207894 cites W4281759126 @default.
• W4387207894 cites W4313597433 @default.
• W4387207894 doi "https://doi.org/10.1016/j.molimm.2023.09.014" @default.
• W4387207894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37778149" @default.
• W4387207894 hasPublicationYear "2023" @default.
• W4387207894 type Work @default.
• W4387207894 citedByCount "0" @default.
• W4387207894 crossrefType "journal-article" @default.
• W4387207894 hasAuthorship W4387207894A5015943062 @default.
• W4387207894 hasAuthorship W4387207894A5019196752 @default.
• W4387207894 hasAuthorship W4387207894A5022295407 @default.
• W4387207894 hasAuthorship W4387207894A5029743510 @default.
• W4387207894 hasAuthorship W4387207894A5038306575 @default.
• W4387207894 hasAuthorship W4387207894A5042453830 @default.
• W4387207894 hasAuthorship W4387207894A5071115755 @default.
• W4387207894 hasAuthorship W4387207894A5083176889 @default.
• W4387207894 hasAuthorship W4387207894A5083820454 @default.
• W4387207894 hasAuthorship W4387207894A5085711857 @default.
• W4387207894 hasConcept C136764020 @default.
• W4387207894 hasConcept C147483822 @default.
• W4387207894 hasConcept C159047783 @default.
• W4387207894 hasConcept C159654299 @default.
• W4387207894 hasConcept C203014093 @default.
• W4387207894 hasConcept C22070199 @default.
• W4387207894 hasConcept C2776555147 @default.
• W4387207894 hasConcept C2778689377 @default.
• W4387207894 hasConcept C2779341262 @default.
• W4387207894 hasConcept C2780931953 @default.
• W4387207894 hasConcept C2781092759 @default.
• W4387207894 hasConcept C2781333301 @default.
• W4387207894 hasConcept C41008148 @default.
• W4387207894 hasConcept C71928629 @default.

• next