FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387208410> ?p ?o ?g. }

• W4387208410 endingPage "341" @default.
• W4387208410 startingPage "329" @default.
• W4387208410 abstract "Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems. The hormones epinephrine and norepinephrine are produced in the adrenal medulla and in the brain, and are universal messengers that trigger the transmission of nerve impulses at synapses, and also have a receptor-mediated effect on immunocompetent cells. The aim of this study was to investigate adrenergic pathway regulation of inflammation on the neutrophil granulocytes in the presence of activators of innate immunity receptors. Materials and Methods. Neutrophil granulocytes were obtained from peripheral blood of healthy volunteers in a density gradient of Histopaque 1077 and Histopaque 1119 (Sigma Aldrich, Steinheim, Germany), and cultured in the presence of LPS, GMDP, epinephrine and norepinephrine. The amount of human neutrophil peptides 1-3 (HNP1-3) was examined using an enzyme-linked immunosorbent assay; the gene expression of TLR4, NOD2, ATF3 and A20 was determined using RT-PCR. Results and Discussion. Norepinephrine (noradrenaline) was found to decrease the synthesis of human neutrophils peptides 1-3 (HNP 1-3 defensins, alone and in the combination with agonists of TLR4 and NOD2 receptors - LPS and GMDP respectively. It was found out that there was no a statistically significant effect of epinephrine (adrenaline) on the production of HNP 1-3, including when combined with LPS and GMDP. As a result of the study, an increase in the levels of expression of the genes TLR4, NOD2 and regulator of inflammatory reactions A20 both in LPS- and GMDP- induced neutrophil culture were uncovered, while ATF3 was increased only in LPS-induced neutrophil culture. Epinephrine demonstrated the absence of a statistically significant effect on the expression of the studied genes. While norepinephrine significantly increased the expression of A20 genes. Conclusion. The data obtained shows that norepinephrine can reduce the synthesis of HNP 1-3, including the one induced by LPS and GMDP. Moreover, the ability of norepinephrine to induce the expression of A20 may play a significant role in modulation of inflammation." @default.
• W4387208410 created "2023-09-30" @default.
• W4387208410 creator A5011119815 @default.
• W4387208410 creator A5092120744 @default.
• W4387208410 creator A5092972881 @default.
• W4387208410 date "2023-12-15" @default.
• W4387208410 modified "2023-10-14" @default.
• W4387208410 title "Inflammatory response modulation by epinephrine and norepinephrine" @default.
• W4387208410 cites W1515724419 @default.
• W4387208410 cites W1561757844 @default.
• W4387208410 cites W169013056 @default.
• W4387208410 cites W1819753035 @default.
• W4387208410 cites W1917777024 @default.
• W4387208410 cites W1965561972 @default.
• W4387208410 cites W1965658052 @default.
• W4387208410 cites W1977160855 @default.
• W4387208410 cites W1992688542 @default.
• W4387208410 cites W1993341098 @default.
• W4387208410 cites W1995461729 @default.
• W4387208410 cites W2001166572 @default.
• W4387208410 cites W2003634035 @default.
• W4387208410 cites W2004759354 @default.
• W4387208410 cites W2011334431 @default.
• W4387208410 cites W2026398626 @default.
• W4387208410 cites W2032679339 @default.
• W4387208410 cites W2034236127 @default.
• W4387208410 cites W2035025683 @default.
• W4387208410 cites W2043198295 @default.
• W4387208410 cites W2045362817 @default.
• W4387208410 cites W2068993907 @default.
• W4387208410 cites W2073578515 @default.
• W4387208410 cites W2102552341 @default.
• W4387208410 cites W2108820669 @default.
• W4387208410 cites W2108830583 @default.
• W4387208410 cites W2127239760 @default.
• W4387208410 cites W2140385393 @default.
• W4387208410 cites W2145792387 @default.
• W4387208410 cites W2148619403 @default.
• W4387208410 cites W2155512252 @default.
• W4387208410 cites W2162870899 @default.
• W4387208410 cites W2166688499 @default.
• W4387208410 cites W2174456205 @default.
• W4387208410 cites W2336328518 @default.
• W4387208410 cites W2337752842 @default.
• W4387208410 cites W2788262523 @default.
• W4387208410 cites W2796697766 @default.
• W4387208410 cites W2801035759 @default.
• W4387208410 cites W2809179845 @default.
• W4387208410 cites W2938566986 @default.
• W4387208410 cites W2969329261 @default.
• W4387208410 cites W3015797918 @default.
• W4387208410 cites W3020901008 @default.
• W4387208410 cites W3049724387 @default.
• W4387208410 cites W3050181739 @default.
• W4387208410 cites W3090518610 @default.
• W4387208410 cites W3096981169 @default.
• W4387208410 cites W3128722634 @default.
• W4387208410 cites W3134303986 @default.
• W4387208410 cites W3154084155 @default.
• W4387208410 cites W3172916279 @default.
• W4387208410 cites W3181781482 @default.
• W4387208410 cites W3185295815 @default.
• W4387208410 cites W3203404038 @default.
• W4387208410 cites W3216729733 @default.
• W4387208410 cites W4200277404 @default.
• W4387208410 cites W4206756949 @default.
• W4387208410 cites W4210294492 @default.
• W4387208410 cites W4237029803 @default.
• W4387208410 cites W4288716862 @default.
• W4387208410 cites W4292482612 @default.
• W4387208410 cites W4293217327 @default.
• W4387208410 cites W4315699911 @default.
• W4387208410 cites W4315700866 @default.
• W4387208410 cites W4316041197 @default.
• W4387208410 doi "https://doi.org/10.22363/2313-0245-2023-27-3-329-341" @default.
• W4387208410 hasPublicationYear "2023" @default.
• W4387208410 type Work @default.
• W4387208410 citedByCount "0" @default.
• W4387208410 crossrefType "journal-article" @default.
• W4387208410 hasAuthorship W4387208410A5011119815 @default.
• W4387208410 hasAuthorship W4387208410A5092120744 @default.
• W4387208410 hasAuthorship W4387208410A5092972881 @default.
• W4387208410 hasBestOaLocation W43872084101 @default.
• W4387208410 hasConcept C126322002 @default.
• W4387208410 hasConcept C134018914 @default.
• W4387208410 hasConcept C136449434 @default.
• W4387208410 hasConcept C170493617 @default.
• W4387208410 hasConcept C203014093 @default.
• W4387208410 hasConcept C2775859304 @default.
• W4387208410 hasConcept C2775894120 @default.
• W4387208410 hasConcept C2776070231 @default.
• W4387208410 hasConcept C2776914184 @default.
• W4387208410 hasConcept C2777597313 @default.
• W4387208410 hasConcept C2778514916 @default.
• W4387208410 hasConcept C40465926 @default.
• W4387208410 hasConcept C513476851 @default.
• W4387208410 hasConcept C71924100 @default.
• W4387208410 hasConcept C86803240 @default.

• next