FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387208524> ?p ?o ?g. }

• W4387208524 abstract "ABSTRACT Background Membranous nephropathy (MN) is the leading cause of adult-onset nephrotic syndrome, with primary MN of unclear cause accounting for 80% of cases. Retrospective clinical research reported that MN occurring in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients was triggered by nephrotoxic drugs or of unknown cause. However, whether RA or AS itself increases the risk of developing MN is unknown. Methods We conducted mendelian randomization (MR) analysis to evaluate the causal effects of RA or AS on MN using genome-wide association study (GWAS) statistics. The inverse variance weighted (IVW) method was the primary analysis, and several supplementary analyses and sensitivity analyses were performed to test the causal estimates. Results We obtained 30 valid instrumental variables (IVs) of RA and 16 valid IVs of AS from large-scale open-access GWASs. The genetically predicted RA significantly increased the risk of MN [IVW odds ratios (OR) = 1.327, 95% confidence interval (CI) = (1.124, 1.565), P = 8.051 × 10−4]. Three supplementary MR analyses provided the consistent positive causal effect of RA on MN (all P &lt; 0.05). No horizontal pleiotropy was detected by MR Egger intercept analysis (P = 0.411). However, the genetically predicted AS had no causal effect on MN by IVW and supplementary analysis (all P &gt; 0.05). Conclusions Genetically predicted RA could increase the risk of MN, but genetically predicted AS was not associated with MN. Screening for kidney involvement in RA patients should be noted, and active treatment of RA will reduce the public health burden of MN." @default.
• W4387208524 created "2023-09-30" @default.
• W4387208524 creator A5003855247 @default.
• W4387208524 creator A5024778679 @default.
• W4387208524 creator A5053518219 @default.
• W4387208524 creator A5082289102 @default.
• W4387208524 creator A5083313545 @default.
• W4387208524 date "2023-09-29" @default.
• W4387208524 modified "2023-10-16" @default.
• W4387208524 title "Causal effects of rheumatoid arthritis or ankylosing spondylitis on membranous nephropathy: a two-sample mendelian randomization study" @default.
• W4387208524 cites W1751058445 @default.
• W4387208524 cites W1967239133 @default.
• W4387208524 cites W1985048725 @default.
• W4387208524 cites W1986537861 @default.
• W4387208524 cites W1989590412 @default.
• W4387208524 cites W2020104306 @default.
• W4387208524 cites W2026853694 @default.
• W4387208524 cites W2038785875 @default.
• W4387208524 cites W2041514348 @default.
• W4387208524 cites W2072672475 @default.
• W4387208524 cites W2084853640 @default.
• W4387208524 cites W2113699335 @default.
• W4387208524 cites W2118967025 @default.
• W4387208524 cites W2142136897 @default.
• W4387208524 cites W2154545895 @default.
• W4387208524 cites W2161152188 @default.
• W4387208524 cites W2265865881 @default.
• W4387208524 cites W2324862792 @default.
• W4387208524 cites W2336207146 @default.
• W4387208524 cites W2343737139 @default.
• W4387208524 cites W2488281607 @default.
• W4387208524 cites W2519199594 @default.
• W4387208524 cites W2529699441 @default.
• W4387208524 cites W2573829190 @default.
• W4387208524 cites W2597850678 @default.
• W4387208524 cites W2617482626 @default.
• W4387208524 cites W2750640036 @default.
• W4387208524 cites W2759666557 @default.
• W4387208524 cites W2765273698 @default.
• W4387208524 cites W2769724423 @default.
• W4387208524 cites W2787384683 @default.
• W4387208524 cites W2805983714 @default.
• W4387208524 cites W2806973106 @default.
• W4387208524 cites W2955177623 @default.
• W4387208524 cites W2995495091 @default.
• W4387208524 cites W3006272025 @default.
• W4387208524 cites W3013248105 @default.
• W4387208524 cites W3080205114 @default.
• W4387208524 cites W3102563980 @default.
• W4387208524 cites W3107334770 @default.
• W4387208524 cites W3126993375 @default.
• W4387208524 cites W3146924029 @default.
• W4387208524 cites W3215717227 @default.
• W4387208524 cites W4205682661 @default.
• W4387208524 cites W4205819821 @default.
• W4387208524 cites W4206671482 @default.
• W4387208524 cites W4220983942 @default.
• W4387208524 cites W4225133335 @default.
• W4387208524 cites W4253754191 @default.
• W4387208524 doi "https://doi.org/10.1093/ckj/sfad209" @default.
• W4387208524 hasPublicationYear "2023" @default.
• W4387208524 type Work @default.
• W4387208524 citedByCount "0" @default.
• W4387208524 crossrefType "journal-article" @default.
• W4387208524 hasAuthorship W4387208524A5003855247 @default.
• W4387208524 hasAuthorship W4387208524A5024778679 @default.
• W4387208524 hasAuthorship W4387208524A5053518219 @default.
• W4387208524 hasAuthorship W4387208524A5082289102 @default.
• W4387208524 hasAuthorship W4387208524A5083313545 @default.
• W4387208524 hasBestOaLocation W43872085241 @default.
• W4387208524 hasConcept C104317684 @default.
• W4387208524 hasConcept C126322002 @default.
• W4387208524 hasConcept C135763542 @default.
• W4387208524 hasConcept C143998085 @default.
• W4387208524 hasConcept C156957248 @default.
• W4387208524 hasConcept C2777402515 @default.
• W4387208524 hasConcept C2777575956 @default.
• W4387208524 hasConcept C2779901538 @default.
• W4387208524 hasConcept C2993967602 @default.
• W4387208524 hasConcept C44249647 @default.
• W4387208524 hasConcept C54355233 @default.
• W4387208524 hasConcept C71924100 @default.
• W4387208524 hasConcept C86803240 @default.
• W4387208524 hasConcept C90924648 @default.
• W4387208524 hasConceptScore W4387208524C104317684 @default.
• W4387208524 hasConceptScore W4387208524C126322002 @default.
• W4387208524 hasConceptScore W4387208524C135763542 @default.
• W4387208524 hasConceptScore W4387208524C143998085 @default.
• W4387208524 hasConceptScore W4387208524C156957248 @default.
• W4387208524 hasConceptScore W4387208524C2777402515 @default.
• W4387208524 hasConceptScore W4387208524C2777575956 @default.
• W4387208524 hasConceptScore W4387208524C2779901538 @default.
• W4387208524 hasConceptScore W4387208524C2993967602 @default.
• W4387208524 hasConceptScore W4387208524C44249647 @default.
• W4387208524 hasConceptScore W4387208524C54355233 @default.
• W4387208524 hasConceptScore W4387208524C71924100 @default.
• W4387208524 hasConceptScore W4387208524C86803240 @default.
• W4387208524 hasConceptScore W4387208524C90924648 @default.
• W4387208524 hasLocation W43872085241 @default.
• W4387208524 hasOpenAccess W4387208524 @default.

• next