FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387208897> ?p ?o ?g. }

• W4387208897 endingPage "e193" @default.
• W4387208897 startingPage "e193" @default.
• W4387208897 abstract "Cardiac arrhythmias are usually treated with invasive, time consuming catheter ablation techniques. While recently stereotactic body radiotherapy (SBRT) is an emerging non-invasive treatment in the management of cardiac arrhythmias. To identify and assess the cardiac radioablation by MR examination, including diffusion-weighted MRI, dynamic Gd-enhanced MRI, MR spectroscopy, and T2-weighted MRI early after SBRT is very difficult. We have been developing the free radical imaging methods using Dynamic Nuclear Polarization (DNP)-MRI with nitroxyl radicals as a redox probe (e.g., 4-Methacryloyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempo methacrylate; TempoMC)). In this study, we examined the possibility of in vivo spatiotemporal visualization of SBRT for cardiac radioablation to the cavotricuspid isthmus (CTI) based on redox reaction by in vivo DNP-MRI.All animal procedures were approved by institutional animal care and use committee and performed in full compliance with its guidelines. This study was conducted with two approaches. First, four mini pigs underwent electrophysiology assessment using electroanatomic mapping (EAM) before and 3 months after SBRT with single-fraction doses of 25 Gy. The target of CTI was defined by cardiologist. We defined the planning target volume (PTV): the internal margin (IM) + set up margin (SM) = SI 15 mm, AP 10mm, LR 10 mm were added to the target. Radiotherapy plans were created by the software used in daily clinical practice. Second, free radical imaging by low filed type of DNP-MRI was performed on the four mice before and after 25 Gy and 10 Gy irradiation to whole heart. ESR signal measurements were also performed.A total dose of 25 Gy was successfully delivered to PTV in a single procedure in all mini pigs. EAM visualized the irradiated site and confirmed clockwise conduction block across the CTI. Although routine MRI could not detect the cardiac radiation injury clearly, the four mice of heart were well delineated on MRI and clearly visualized by DNP-MRI. DNP-MRI signal of TempoMC were decreased depending on prescribed irradiation dose.These data demonstrated the safety and feasibility of SBRT for creating conduction block across the CTI in mini pigs. Although to identify and assess the irradiated site by routine MR examination was impossible, the free radical imaging methods using Dynamic Nuclear Polarization (DNP)-MRI with TempoMC could be a promising successful method for the assessment of cardiac radioablation. This new quantum image by DNP-MRI will open the possibility of treating cardiac arrhythmias by SBRT safety and noninvasively." @default.
• W4387208897 created "2023-09-30" @default.
• W4387208897 creator A5004169348 @default.
• W4387208897 creator A5010314875 @default.
• W4387208897 creator A5017623051 @default.
• W4387208897 creator A5021329884 @default.
• W4387208897 creator A5059133569 @default.
• W4387208897 creator A5085728678 @default.
• W4387208897 creator A5086656145 @default.
• W4387208897 date "2023-10-01" @default.
• W4387208897 modified "2023-10-17" @default.
• W4387208897 title "The New Quantum Image by Dynamic Nuclear Polarized MRI for the Assessment of Cardiac Radioablation to the Cavotricuspid Isthmus" @default.
• W4387208897 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1060" @default.
• W4387208897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37784832" @default.
• W4387208897 hasPublicationYear "2023" @default.
• W4387208897 type Work @default.
• W4387208897 citedByCount "0" @default.
• W4387208897 crossrefType "journal-article" @default.
• W4387208897 hasAuthorship W4387208897A5004169348 @default.
• W4387208897 hasAuthorship W4387208897A5010314875 @default.
• W4387208897 hasAuthorship W4387208897A5017623051 @default.
• W4387208897 hasAuthorship W4387208897A5021329884 @default.
• W4387208897 hasAuthorship W4387208897A5059133569 @default.
• W4387208897 hasAuthorship W4387208897A5085728678 @default.
• W4387208897 hasAuthorship W4387208897A5086656145 @default.
• W4387208897 hasConcept C126838900 @default.
• W4387208897 hasConcept C2989005 @default.
• W4387208897 hasConcept C509974204 @default.
• W4387208897 hasConcept C71924100 @default.
• W4387208897 hasConceptScore W4387208897C126838900 @default.
• W4387208897 hasConceptScore W4387208897C2989005 @default.
• W4387208897 hasConceptScore W4387208897C509974204 @default.
• W4387208897 hasConceptScore W4387208897C71924100 @default.
• W4387208897 hasIssue "2" @default.
• W4387208897 hasLocation W43872088971 @default.
• W4387208897 hasLocation W43872088972 @default.
• W4387208897 hasOpenAccess W4387208897 @default.
• W4387208897 hasPrimaryLocation W43872088971 @default.
• W4387208897 hasRelatedWork W1995899133 @default.
• W4387208897 hasRelatedWork W2003855035 @default.
• W4387208897 hasRelatedWork W2049214470 @default.
• W4387208897 hasRelatedWork W2384708512 @default.
• W4387208897 hasRelatedWork W2568300327 @default.
• W4387208897 hasRelatedWork W3023315196 @default.
• W4387208897 hasRelatedWork W3029247339 @default.
• W4387208897 hasRelatedWork W3030916910 @default.
• W4387208897 hasRelatedWork W3153034825 @default.
• W4387208897 hasRelatedWork W4353055862 @default.
• W4387208897 hasVolume "117" @default.
• W4387208897 isParatext "false" @default.
• W4387208897 isRetracted "false" @default.
• W4387208897 workType "article" @default.