FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387209566> ?p ?o ?g. }

• W4387209566 abstract "The relationship between the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP) and serum homocysteine (Hcy) levels or H-type hypertension in different populations is inconsistent. This study aimed to explore the association between the MTHFR rs1801133 SNP and serum Hcy levels of Zhuang hypertensive patients in the central region of Guangxi.A total of 606 Zhuang inpatients with essential hypertension were recruited in our hospital from August 2016 to December 2018. The patients were divided into H-type hypertension (Hcy > 10 µmol/L, n = 528) and non-H-type hypertension (Hcy ≤ 10 µmol/L, n = 78) groups. At the same time, an age- and sex-matched group of 379 subjects with normal physical examination in our hospital were selected as the control group. Blood biochemical measurements and genotyping of the MTHFR rs1801133 SNP were performed.The prevalence of H-type hypertension was 87.13%. The levels of serum Hcy in patients with hypertension were higher than those in control group (14.20 ± 5.78 μmol/L vs. 11.97 ± 5.39 μmol/L, P < 0.001), especially in patients with H-type hypertension (15.08 ± 5.65 μmol/L, P < 0.001). The frequencies of TT genotype (22.73%) and T allele (46.21%) in patients with H-type hypertension were significantly higher than those in control group (11.35% and 30.47%, respectively) and non-H-type hypertension group (10.26% and 28.85%, respectively; P < 0.001 for all). Multivariate linear regression analysis showed that serum Hcy levels were significantly correlated with creatinine, low-density lipoprotein cholesterol, endogenous creatinine clearance rate, and the MTHFR rs1801133 genotypes in control group, while serum Hcy levels were significantly correlated with creatinine, triglyceride, low-density lipoprotein cholesterol, endogenous creatinine clearance rate, glycosylated hemoglobin, and the MTHFR rs1801133 genotypes in H-type hypertension group (P < 0.05-0.001). Serum Hcy levels in the T allele carriers were higher than those in the T allele noncarriers in both H-type hypertension and control groups.There was closely related between the MTHFR rs1801133 SNP and serum Hcy levels in Zhuang patients with H-type hypertension in the central region of Guangxi. The MTHFR SNP may be an important reason for the increase of serum Hcy levels in Zhuang patients with H-type hypertension in this region." @default.
• W4387209566 created "2023-10-01" @default.
• W4387209566 creator A5019771919 @default.
• W4387209566 creator A5023363460 @default.
• W4387209566 creator A5031852570 @default.
• W4387209566 creator A5036648374 @default.
• W4387209566 creator A5052199092 @default.
• W4387209566 creator A5060013057 @default.
• W4387209566 date "2023-10-01" @default.
• W4387209566 modified "2023-10-02" @default.
• W4387209566 title "Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi" @default.
• W4387209566 cites W1964231389 @default.
• W4387209566 cites W1977989499 @default.
• W4387209566 cites W1984266094 @default.
• W4387209566 cites W1986551091 @default.
• W4387209566 cites W1990517806 @default.
• W4387209566 cites W1993245844 @default.
• W4387209566 cites W2005574273 @default.
• W4387209566 cites W2010352448 @default.
• W4387209566 cites W2014782637 @default.
• W4387209566 cites W2019755550 @default.
• W4387209566 cites W2025785357 @default.
• W4387209566 cites W2035815331 @default.
• W4387209566 cites W2046147899 @default.
• W4387209566 cites W2055717465 @default.
• W4387209566 cites W2069051001 @default.
• W4387209566 cites W2090637200 @default.
• W4387209566 cites W2094878829 @default.
• W4387209566 cites W2102450945 @default.
• W4387209566 cites W2108065192 @default.
• W4387209566 cites W2118981285 @default.
• W4387209566 cites W2124916392 @default.
• W4387209566 cites W2142800783 @default.
• W4387209566 cites W2144673545 @default.
• W4387209566 cites W2158621858 @default.
• W4387209566 cites W2166450210 @default.
• W4387209566 cites W2168991260 @default.
• W4387209566 cites W2192466377 @default.
• W4387209566 cites W2313407016 @default.
• W4387209566 cites W2318255723 @default.
• W4387209566 cites W2406208744 @default.
• W4387209566 cites W2465782399 @default.
• W4387209566 cites W2554849552 @default.
• W4387209566 cites W2563606909 @default.
• W4387209566 cites W2769180642 @default.
• W4387209566 cites W2793955071 @default.
• W4387209566 cites W2991329646 @default.
• W4387209566 cites W3001324598 @default.
• W4387209566 cites W3009203720 @default.
• W4387209566 cites W3049329464 @default.
• W4387209566 cites W3093427387 @default.
• W4387209566 cites W3094024543 @default.
• W4387209566 cites W3159289205 @default.
• W4387209566 cites W3187523064 @default.
• W4387209566 cites W3201919109 @default.
• W4387209566 cites W3207359012 @default.
• W4387209566 cites W4214481241 @default.
• W4387209566 cites W4221062480 @default.
• W4387209566 cites W4223485102 @default.
• W4387209566 cites W4224249510 @default.
• W4387209566 cites W4224320347 @default.
• W4387209566 cites W4226153335 @default.
• W4387209566 cites W4295897060 @default.
• W4387209566 cites W4304112116 @default.
• W4387209566 cites W4306316482 @default.
• W4387209566 cites W4311968916 @default.
• W4387209566 doi "https://doi.org/10.1186/s40885-023-00250-9" @default.
• W4387209566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37777810" @default.
• W4387209566 hasPublicationYear "2023" @default.
• W4387209566 type Work @default.
• W4387209566 citedByCount "0" @default.
• W4387209566 crossrefType "journal-article" @default.
• W4387209566 hasAuthorship W4387209566A5019771919 @default.
• W4387209566 hasAuthorship W4387209566A5023363460 @default.
• W4387209566 hasAuthorship W4387209566A5031852570 @default.
• W4387209566 hasAuthorship W4387209566A5036648374 @default.
• W4387209566 hasAuthorship W4387209566A5052199092 @default.
• W4387209566 hasAuthorship W4387209566A5060013057 @default.
• W4387209566 hasBestOaLocation W43872095661 @default.
• W4387209566 hasConcept C104317684 @default.
• W4387209566 hasConcept C126322002 @default.
• W4387209566 hasConcept C134018914 @default.
• W4387209566 hasConcept C135763542 @default.
• W4387209566 hasConcept C153209595 @default.
• W4387209566 hasConcept C2776523773 @default.
• W4387209566 hasConcept C2777090595 @default.
• W4387209566 hasConcept C2780306776 @default.
• W4387209566 hasConcept C31467283 @default.
• W4387209566 hasConcept C43563269 @default.
• W4387209566 hasConcept C54355233 @default.
• W4387209566 hasConcept C71924100 @default.
• W4387209566 hasConcept C86803240 @default.
• W4387209566 hasConcept C90924648 @default.
• W4387209566 hasConceptScore W4387209566C104317684 @default.
• W4387209566 hasConceptScore W4387209566C126322002 @default.
• W4387209566 hasConceptScore W4387209566C134018914 @default.
• W4387209566 hasConceptScore W4387209566C135763542 @default.
• W4387209566 hasConceptScore W4387209566C153209595 @default.
• W4387209566 hasConceptScore W4387209566C2776523773 @default.
• W4387209566 hasConceptScore W4387209566C2777090595 @default.

• next