Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387209663> ?p ?o ?g. }
- W4387209663 abstract "Abstract Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulate that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy. We employ atlas- and voxel-based connectivity approaches to analyze neuroimaging data acquired from two groups of healthy participants. Our findings are consistent across six complementary processing pipelines: 1) SFC and its temporal variance respectively decrease and increase across the unimodal-transmodal and granular-agranular gradients; 2) increased myelination and lower EI-ratio are associated with more rigid SFC and restricted moment-to-moment SFC fluctuations; 3) a gradual shift from EI-ratio to myelination as the principal predictor of SFC occurs when traversing from granular to agranular cortical regions. Collectively, our work delivers a framework to conceptualize structure-function relationships in the human brain, paving the way for an improved understanding of how demyelination and/or EI-imbalances induce reorganization in brain disorders." @default.
- W4387209663 created "2023-10-01" @default.
- W4387209663 creator A5006851856 @default.
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- W4387209663 date "2023-09-30" @default.
- W4387209663 modified "2023-10-05" @default.
- W4387209663 title "Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex" @default.
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