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- W4387212616 abstract "Treatment with 3-year of adjuvant osimertinib is considered a new standard in patients with completely resected stage I-IIIA non-small cell lung cancer (NSCLC) harboring a common sensitizing EGFR-mutation. This therapeutic approach significantly prolonged the disease-free survival and the overall survival versus placebo and showed a significant role in preventing the occurrence of brain metastases. However, many unanswered questions still remain, including the optimal duration of this therapy, whether all patients benefit from adjuvant osimertinib and the role of adjuvant chemotherapy in this population. Indeed, there is a renewed interest in neoadjuvant strategies with targeted therapies in resectable NSCLC harboring oncogenic drivers. In the light of these considerations, we discuss the past and current treatment options, as well as the clinical challenges that should be addressed to optimize the treatment outcomes in this patient population." @default.
- W4387212616 created "2023-10-01" @default.
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- W4387212616 date "2023-09-01" @default.
- W4387212616 modified "2023-10-16" @default.
- W4387212616 title "Perioperative treatment strategies in EGFR-mutant early-stage NSCLC: current evidence and future challenges" @default.
- W4387212616 doi "https://doi.org/10.1016/j.jtho.2023.09.1451" @default.
- W4387212616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37783386" @default.
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