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• W4387212908 abstract "Objective Anterior knee pain (AKP) is associated with patellofemoral osteoarthritis (PFOA), but longitudinal studies are lacking. If AKP precedes PFOA, it may create an opportunity to identify and intervene earlier in the disease process. The purpose of this study was to examine the longitudinal relation of AKP to worsening PF cartilage over two years. Design Participants were recruited from the Multicenter Osteoarthritis Study (MOST), a longitudinal study of individuals with or at-risk for knee OA. Exclusion criteria included bilateral knee replacements, arthritis other than OA, and radiographic PFOA. At baseline, participants completed a knee pain map questionnaire and underwent knee MRI. Imaging was repeated at 2-year follow-up. Exposure was presence of frequent AKP. Outcome was worsening cartilage damage in the PF joint defined as increase in MRI Osteoarthritis Knee Score from baseline to 2 years. Log-binomial models were used to calculate risk ratios (RR). Results One knee from 1,083 participants (age 56.7 ± 6.6 years; BMI 28.0 ± 4.9 kg/m2) was included. Frequent AKP and frequent isolated AKP were present at baseline in 14.5% and 3.6%, respectively. Frequent AKP was associated with an increased risk (RR: 1.78, 95% CI: 1.21, 2.62) of 2-year worsening cartilage damage in the lateral PF compartment. No association was found between frequent AKP and worsening in the medial PF joint. Conclusion Frequent AKP at baseline was associated with worsening cartilage damage in the lateral PF joint over 2 years. Anterior knee pain (AKP) is associated with patellofemoral osteoarthritis (PFOA), but longitudinal studies are lacking. If AKP precedes PFOA, it may create an opportunity to identify and intervene earlier in the disease process. The purpose of this study was to examine the longitudinal relation of AKP to worsening PF cartilage over two years. Participants were recruited from the Multicenter Osteoarthritis Study (MOST), a longitudinal study of individuals with or at-risk for knee OA. Exclusion criteria included bilateral knee replacements, arthritis other than OA, and radiographic PFOA. At baseline, participants completed a knee pain map questionnaire and underwent knee MRI. Imaging was repeated at 2-year follow-up. Exposure was presence of frequent AKP. Outcome was worsening cartilage damage in the PF joint defined as increase in MRI Osteoarthritis Knee Score from baseline to 2 years. Log-binomial models were used to calculate risk ratios (RR). One knee from 1,083 participants (age 56.7 ± 6.6 years; BMI 28.0 ± 4.9 kg/m2) was included. Frequent AKP and frequent isolated AKP were present at baseline in 14.5% and 3.6%, respectively. Frequent AKP was associated with an increased risk (RR: 1.78, 95% CI: 1.21, 2.62) of 2-year worsening cartilage damage in the lateral PF compartment. No association was found between frequent AKP and worsening in the medial PF joint. Frequent AKP at baseline was associated with worsening cartilage damage in the lateral PF joint over 2 years." @default.
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• W4387212908 date "2023-09-01" @default.
• W4387212908 modified "2023-10-11" @default.
• W4387212908 title "Associations between Anterior Knee Pain and 2-year Patellofemoral Cartilage Worsening: The MOST Study" @default.
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• W4387212908 doi "https://doi.org/10.1016/j.joca.2023.09.008" @default.
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