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- W4387226409 abstract "The Human Immunodeficiency Virus (HIV) infects approximately 40 million people globally, and one million people die every year from Acquired Immune Deficiency Syndrome (AIDS)-related illnesses. The HIV-1 virus proliferates, infects people, and kills those who host the virus. Unfortunately, there is little research on the structural interactions between HIV-1 proteins and human cell receptors. This study examined the interactions between the HIV-1 envelope glycoprotein gp120 and the human lymphocyte receptor integrin α4β7, the putative first long-range receptor for the envelope glycoprotein of the virus in mucosal tissues. The specific site of binding between the glycoprotein and the receptor has not been determined. However, discovering the binding site can open the field towards the research of molecules that could potentially block this interaction and prevent the initial binding of the HIV1 virus. We hypothesized that the V1 and V2 loops of the envelope glycoprotein of HIV-1 are involved in the binding between the HIV-1 virus and the human lymphocyte receptor α4β7. Using structural analysis software, we analyzed the electrostatics and structural interactions between the glycoprotein and receptor. We report structural insights into the interactions between α4β7 and envelope glycoprotein gp120. Our data support the claim that the V1 loop is involved in the binding between α4β7 and the HIV-1 envelope glycoprotein through molecular dockings." @default.
- W4387226409 created "2023-10-01" @default.
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- W4387226409 date "2021-01-01" @default.
- W4387226409 modified "2023-10-01" @default.
- W4387226409 title "The analysis of the viral transmission and structural interactions between the HIV-1 envelope glycoprotein and the lymphocyte receptor integrin α4β7" @default.
- W4387226409 doi "https://doi.org/10.59720/20-238" @default.
- W4387226409 hasPublicationYear "2021" @default.
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