Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387226710> ?p ?o ?g. }
- W4387226710 endingPage "369" @default.
- W4387226710 startingPage "363" @default.
- W4387226710 abstract "Inhaled nitric oxide (iNO) relaxes the pulmonary circulation and variably increases the left ventricular preload and pulmonary artery wedge pressure (PAWP)-hemodynamic information that may help guide treatment decisions and assess prognosis in patients with combined precapillary and postcapillary pulmonary hypertension (PH). We included consecutive patients with combined precapillary and postcapillary PH (mean pulmonary artery pressure >20 mm Hg, PAWP >15 mm Hg, and pulmonary vascular resistance [PVR] >2 Woods unit [WU]) who underwent right-sided cardiac catheterization with iNO at the Cleveland Clinic Pulmonary Vascular Disease program between 2017 and 2022. We included 104 patients with baseline PAWP and PVR of 22.2 ± 4.2 mm Hg and 6.1 ± 3.2 WU, respectively. Pulmonary arterial hypertension (PAH) with postcapillary component and PH left heart disease with precapillary component were identified in 27 (26%) and 77 patients (74%), respectively. No side effects were noted during the administration of iNO. During iNO, the PVR decreased 1.1 ± 1.4 WU and the PAWP increased 1.3 ± 3.7 mm Hg. A more pronounced increase in PAWP with iNO was associated with a decrease in PVR (R -0.35, p <0.001) and increase in stroke volume (R 0.20, p = 0.046). Tolerance to PAH-specific medications, overall survival, and heart failure hospitalizations were not significantly associated with the change in PAWP or PVR with iNO. In conclusion, in patients with combined precapillary and postcapillary PH, iNO challenge is safe and caused a significant decrease in PVR, with an increase in PAWP. The changes in PAWP and PVR during iNO administration were not associated with tolerance to PAH-specific medications, heart failure-related hospitalization, or survival." @default.
- W4387226710 created "2023-10-01" @default.
- W4387226710 creator A5020022607 @default.
- W4387226710 creator A5027390072 @default.
- W4387226710 creator A5042047903 @default.
- W4387226710 creator A5056821462 @default.
- W4387226710 creator A5062659005 @default.
- W4387226710 creator A5066111419 @default.
- W4387226710 creator A5082127941 @default.
- W4387226710 creator A5089188860 @default.
- W4387226710 date "2023-11-01" @default.
- W4387226710 modified "2023-10-03" @default.
- W4387226710 title "Can Inhaled Nitric Oxide Response Predict Tolerance to Therapies and Survival in Patients With Combined Precapillary and Postcapillary Pulmonary Hypertension?" @default.
- W4387226710 cites W122121821 @default.
- W4387226710 cites W1865246179 @default.
- W4387226710 cites W1968854627 @default.
- W4387226710 cites W1997713908 @default.
- W4387226710 cites W2018759973 @default.
- W4387226710 cites W2025565886 @default.
- W4387226710 cites W2026668204 @default.
- W4387226710 cites W2031480665 @default.
- W4387226710 cites W2051857669 @default.
- W4387226710 cites W2078401517 @default.
- W4387226710 cites W2100584927 @default.
- W4387226710 cites W2118726397 @default.
- W4387226710 cites W2119338378 @default.
- W4387226710 cites W2148668042 @default.
- W4387226710 cites W2160327396 @default.
- W4387226710 cites W2161671586 @default.
- W4387226710 cites W2293750515 @default.
- W4387226710 cites W2314982337 @default.
- W4387226710 cites W2336629350 @default.
- W4387226710 cites W2505609029 @default.
- W4387226710 cites W2904180601 @default.
- W4387226710 cites W2904321847 @default.
- W4387226710 cites W2970415110 @default.
- W4387226710 cites W2973605349 @default.
- W4387226710 cites W2997518934 @default.
- W4387226710 cites W3006650630 @default.
- W4387226710 cites W3029427220 @default.
- W4387226710 cites W3045197041 @default.
- W4387226710 cites W4284959141 @default.
- W4387226710 cites W4293207258 @default.
- W4387226710 cites W4296988762 @default.
- W4387226710 cites W4377232207 @default.
- W4387226710 doi "https://doi.org/10.1016/j.amjcard.2023.09.032" @default.
- W4387226710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37778225" @default.
- W4387226710 hasPublicationYear "2023" @default.
- W4387226710 type Work @default.
- W4387226710 citedByCount "0" @default.
- W4387226710 crossrefType "journal-article" @default.
- W4387226710 hasAuthorship W4387226710A5020022607 @default.
- W4387226710 hasAuthorship W4387226710A5027390072 @default.
- W4387226710 hasAuthorship W4387226710A5042047903 @default.
- W4387226710 hasAuthorship W4387226710A5056821462 @default.
- W4387226710 hasAuthorship W4387226710A5062659005 @default.
- W4387226710 hasAuthorship W4387226710A5066111419 @default.
- W4387226710 hasAuthorship W4387226710A5082127941 @default.
- W4387226710 hasAuthorship W4387226710A5089188860 @default.
- W4387226710 hasConcept C126322002 @default.
- W4387226710 hasConcept C139940330 @default.
- W4387226710 hasConcept C146556889 @default.
- W4387226710 hasConcept C164705383 @default.
- W4387226710 hasConcept C178853913 @default.
- W4387226710 hasConcept C2778198053 @default.
- W4387226710 hasConcept C2780930700 @default.
- W4387226710 hasConcept C2780940725 @default.
- W4387226710 hasConcept C48277249 @default.
- W4387226710 hasConcept C519581460 @default.
- W4387226710 hasConcept C58245268 @default.
- W4387226710 hasConcept C71924100 @default.
- W4387226710 hasConceptScore W4387226710C126322002 @default.
- W4387226710 hasConceptScore W4387226710C139940330 @default.
- W4387226710 hasConceptScore W4387226710C146556889 @default.
- W4387226710 hasConceptScore W4387226710C164705383 @default.
- W4387226710 hasConceptScore W4387226710C178853913 @default.
- W4387226710 hasConceptScore W4387226710C2778198053 @default.
- W4387226710 hasConceptScore W4387226710C2780930700 @default.
- W4387226710 hasConceptScore W4387226710C2780940725 @default.
- W4387226710 hasConceptScore W4387226710C48277249 @default.
- W4387226710 hasConceptScore W4387226710C519581460 @default.
- W4387226710 hasConceptScore W4387226710C58245268 @default.
- W4387226710 hasConceptScore W4387226710C71924100 @default.
- W4387226710 hasLocation W43872267101 @default.
- W4387226710 hasLocation W43872267102 @default.
- W4387226710 hasOpenAccess W4387226710 @default.
- W4387226710 hasPrimaryLocation W43872267101 @default.
- W4387226710 hasRelatedWork W104098193 @default.
- W4387226710 hasRelatedWork W1967586188 @default.
- W4387226710 hasRelatedWork W1978502602 @default.
- W4387226710 hasRelatedWork W1987186097 @default.
- W4387226710 hasRelatedWork W2010738716 @default.
- W4387226710 hasRelatedWork W2151108455 @default.
- W4387226710 hasRelatedWork W2362896919 @default.
- W4387226710 hasRelatedWork W2415947716 @default.
- W4387226710 hasRelatedWork W2614039685 @default.
- W4387226710 hasRelatedWork W2918059625 @default.
- W4387226710 hasVolume "207" @default.