FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387226863> ?p ?o ?g. }

• W4387226863 endingPage "106580" @default.
• W4387226863 startingPage "106580" @default.
• W4387226863 abstract "Although human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients typically experience excellent survival, 15–20 % of patients recur after treatment with chemotherapy and radiation. Therefore, there is a need for biomarkers of treatment failure to guide treatment intensity. Whole genome sequencing was carried out on HPV+OPSCC patients who were primarily treated with concurrent chemotherapy (cisplatin) and radiation. We then explored whether the loss of LRP1B was sufficient to drive an aggressive phenotype, and promote a resistance to cisplatin and radiation therapy both in vitro using HPV+ cell lines (93VU147T, UMSCC47, UWO37 and UWO23) and in vivo. Through integrative genomic analysis of three HPV+OPSCC tumour datasets, we identified that deletion of LRP1B was enriched in samples that recurred following chemo-radiation. Knockdown using siRNA in four HPV+ cell lines (UWO23, UWO37, UMSCC47 and 93VU147T) resulted in increased proliferation of all cases. CRISPR/Cas9 deletion of LRP1B in the same cell line panel demonstrated increased proliferation, clonogenic growth and migration, as well as resistance to both cisplatin and radiation in LRP1B deleted cells compared to their respective non-targeting control cells. Cell line derived xenograft studies indicated that the LRP1B knockout tumours were more resistant to cisplatin and radiation therapy compared to their controls invivo. Taken together, our work implicates LRP1B deletion as a potential biomarker for identifying treatment resistant HPV+ OPSCC cases." @default.
• W4387226863 created "2023-10-01" @default.
• W4387226863 creator A5000956537 @default.
• W4387226863 creator A5003106898 @default.
• W4387226863 creator A5007657275 @default.
• W4387226863 creator A5010749017 @default.
• W4387226863 creator A5021762321 @default.
• W4387226863 creator A5032999963 @default.
• W4387226863 creator A5041911479 @default.
• W4387226863 creator A5054905411 @default.
• W4387226863 creator A5058914453 @default.
• W4387226863 creator A5073895768 @default.
• W4387226863 creator A5077305666 @default.
• W4387226863 creator A5090288280 @default.
• W4387226863 date "2023-11-01" @default.
• W4387226863 modified "2023-10-16" @default.
• W4387226863 title "Loss of LRP1B expression drives acquired chemo and radio-resistance in HPV-positive head and neck cancer" @default.
• W4387226863 cites W1967186095 @default.
• W4387226863 cites W1979888611 @default.
• W4387226863 cites W1980180109 @default.
• W4387226863 cites W1986241711 @default.
• W4387226863 cites W2002775053 @default.
• W4387226863 cites W2019651806 @default.
• W4387226863 cites W2034655041 @default.
• W4387226863 cites W2079998038 @default.
• W4387226863 cites W2089715890 @default.
• W4387226863 cites W2110664940 @default.
• W4387226863 cites W2124891284 @default.
• W4387226863 cites W2127256767 @default.
• W4387226863 cites W2140624006 @default.
• W4387226863 cites W2157852151 @default.
• W4387226863 cites W2160878816 @default.
• W4387226863 cites W2310001042 @default.
• W4387226863 cites W2337982522 @default.
• W4387226863 cites W2345692510 @default.
• W4387226863 cites W2507735839 @default.
• W4387226863 cites W2605890878 @default.
• W4387226863 cites W2744038873 @default.
• W4387226863 cites W2799975383 @default.
• W4387226863 cites W2904887959 @default.
• W4387226863 cites W2942061117 @default.
• W4387226863 cites W2969894933 @default.
• W4387226863 cites W3158867830 @default.
• W4387226863 cites W3163446898 @default.
• W4387226863 cites W4310370069 @default.
• W4387226863 cites W4311204820 @default.
• W4387226863 doi "https://doi.org/10.1016/j.oraloncology.2023.106580" @default.
• W4387226863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37778229" @default.
• W4387226863 hasPublicationYear "2023" @default.
• W4387226863 type Work @default.
• W4387226863 citedByCount "0" @default.
• W4387226863 crossrefType "journal-article" @default.
• W4387226863 hasAuthorship W4387226863A5000956537 @default.
• W4387226863 hasAuthorship W4387226863A5003106898 @default.
• W4387226863 hasAuthorship W4387226863A5007657275 @default.
• W4387226863 hasAuthorship W4387226863A5010749017 @default.
• W4387226863 hasAuthorship W4387226863A5021762321 @default.
• W4387226863 hasAuthorship W4387226863A5032999963 @default.
• W4387226863 hasAuthorship W4387226863A5041911479 @default.
• W4387226863 hasAuthorship W4387226863A5054905411 @default.
• W4387226863 hasAuthorship W4387226863A5058914453 @default.
• W4387226863 hasAuthorship W4387226863A5073895768 @default.
• W4387226863 hasAuthorship W4387226863A5077305666 @default.
• W4387226863 hasAuthorship W4387226863A5090288280 @default.
• W4387226863 hasBestOaLocation W43872268631 @default.
• W4387226863 hasConcept C117262875 @default.
• W4387226863 hasConcept C126322002 @default.
• W4387226863 hasConcept C143998085 @default.
• W4387226863 hasConcept C207001950 @default.
• W4387226863 hasConcept C2776530083 @default.
• W4387226863 hasConcept C2776694085 @default.
• W4387226863 hasConcept C2778239845 @default.
• W4387226863 hasConcept C502942594 @default.
• W4387226863 hasConcept C509974204 @default.
• W4387226863 hasConcept C54355233 @default.
• W4387226863 hasConcept C71924100 @default.
• W4387226863 hasConcept C86803240 @default.
• W4387226863 hasConceptScore W4387226863C117262875 @default.
• W4387226863 hasConceptScore W4387226863C126322002 @default.
• W4387226863 hasConceptScore W4387226863C143998085 @default.
• W4387226863 hasConceptScore W4387226863C207001950 @default.
• W4387226863 hasConceptScore W4387226863C2776530083 @default.
• W4387226863 hasConceptScore W4387226863C2776694085 @default.
• W4387226863 hasConceptScore W4387226863C2778239845 @default.
• W4387226863 hasConceptScore W4387226863C502942594 @default.
• W4387226863 hasConceptScore W4387226863C509974204 @default.
• W4387226863 hasConceptScore W4387226863C54355233 @default.
• W4387226863 hasConceptScore W4387226863C71924100 @default.
• W4387226863 hasConceptScore W4387226863C86803240 @default.
• W4387226863 hasFunder F4320334506 @default.
• W4387226863 hasLocation W43872268631 @default.
• W4387226863 hasLocation W43872268632 @default.
• W4387226863 hasOpenAccess W4387226863 @default.
• W4387226863 hasPrimaryLocation W43872268631 @default.
• W4387226863 hasRelatedWork W2034722665 @default.
• W4387226863 hasRelatedWork W2089609493 @default.
• W4387226863 hasRelatedWork W2147863910 @default.
• W4387226863 hasRelatedWork W2347438058 @default.

• next