Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387230772> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4387230772 endingPage "2408" @default.
- W4387230772 startingPage "2408" @default.
- W4387230772 abstract "Infliximab (IFX) concentrations are a predictive factor (PF) of pharmacokinetic (PK) origin in the treatment of Crohn’s disease (CD). We evaluated Clearance, another PF of PK origin, either alone or in combination with concentrations. They were evaluated from two cohorts, the first designed to receive standard dosing (n = 37), and the second designed to proactively target therapeutic IFX concentrations (n = 108). Concentrations were measured using homogeneous mobility shift assay. Clearance was estimated using the nonlinear mixed effects methods with Bayesian priors. C-reactive protein-based clinical remission (<3 μg/L in the absence of symptoms) was used for the disease control outcome measure. Longitudinal changes in disease control due to factors including time, IFX concentration, and Clearance were analyzed using repeated event analysis. Change in objective function value (∆OFV) was calculated to compare concentration and Clearance. The results indicated that lower baseline Clearance and proactive dosing associated with enhanced disease control during induction (p < 0.01). Higher IFX concentrations and lower Clearance measured at the second, third, and fourth infusion yielded improved disease control during maintenance (p < 0.032). During maintenance, the association with disease control was better with Clearance than with concentrations (∆OFV = −19.2; p < 0.001), and the combination of both further minimized OFV (p < 0.001) with markedly improved clinical yield in the presence of both PF of PK origin. We conclude that the combination of IFX concentration and Clearance are better predictors of therapeutic outcome compared with either one alone." @default.
- W4387230772 created "2023-10-02" @default.
- W4387230772 creator A5021425326 @default.
- W4387230772 creator A5022984619 @default.
- W4387230772 creator A5039997334 @default.
- W4387230772 creator A5064070610 @default.
- W4387230772 creator A5073369495 @default.
- W4387230772 creator A5074786238 @default.
- W4387230772 date "2023-09-30" @default.
- W4387230772 modified "2023-10-09" @default.
- W4387230772 title "The Combination of Predictive Factors of Pharmacokinetic Origin Associates with Enhanced Disease Control during Treatment of Pediatric Crohn’s Disease with Infliximab" @default.
- W4387230772 cites W1997999969 @default.
- W4387230772 cites W2003835888 @default.
- W4387230772 cites W2013201041 @default.
- W4387230772 cites W2059843231 @default.
- W4387230772 cites W2064189084 @default.
- W4387230772 cites W2530995556 @default.
- W4387230772 cites W2741466972 @default.
- W4387230772 cites W2781482422 @default.
- W4387230772 cites W2790512231 @default.
- W4387230772 cites W2795832935 @default.
- W4387230772 cites W2898464095 @default.
- W4387230772 cites W2916794721 @default.
- W4387230772 cites W2921300065 @default.
- W4387230772 cites W2944754729 @default.
- W4387230772 cites W2949255324 @default.
- W4387230772 cites W2951297589 @default.
- W4387230772 cites W2978880955 @default.
- W4387230772 cites W2999400123 @default.
- W4387230772 cites W3004803806 @default.
- W4387230772 cites W3018394618 @default.
- W4387230772 cites W3111210633 @default.
- W4387230772 cites W3157739928 @default.
- W4387230772 cites W3190445083 @default.
- W4387230772 cites W3200708660 @default.
- W4387230772 cites W4200252628 @default.
- W4387230772 cites W4205385841 @default.
- W4387230772 cites W4205778356 @default.
- W4387230772 cites W4206949242 @default.
- W4387230772 cites W4211117698 @default.
- W4387230772 cites W4220938665 @default.
- W4387230772 cites W4280535403 @default.
- W4387230772 cites W4281761464 @default.
- W4387230772 cites W4293564155 @default.
- W4387230772 doi "https://doi.org/10.3390/pharmaceutics15102408" @default.
- W4387230772 hasPublicationYear "2023" @default.
- W4387230772 type Work @default.
- W4387230772 citedByCount "0" @default.
- W4387230772 crossrefType "journal-article" @default.
- W4387230772 hasAuthorship W4387230772A5021425326 @default.
- W4387230772 hasAuthorship W4387230772A5022984619 @default.
- W4387230772 hasAuthorship W4387230772A5039997334 @default.
- W4387230772 hasAuthorship W4387230772A5064070610 @default.
- W4387230772 hasAuthorship W4387230772A5073369495 @default.
- W4387230772 hasAuthorship W4387230772A5074786238 @default.
- W4387230772 hasBestOaLocation W43872307721 @default.
- W4387230772 hasConcept C111113717 @default.
- W4387230772 hasConcept C112705442 @default.
- W4387230772 hasConcept C126322002 @default.
- W4387230772 hasConcept C2777138892 @default.
- W4387230772 hasConcept C2777288759 @default.
- W4387230772 hasConcept C2778260677 @default.
- W4387230772 hasConcept C2779134260 @default.
- W4387230772 hasConcept C2779280984 @default.
- W4387230772 hasConcept C71924100 @default.
- W4387230772 hasConcept C90924648 @default.
- W4387230772 hasConcept C98274493 @default.
- W4387230772 hasConceptScore W4387230772C111113717 @default.
- W4387230772 hasConceptScore W4387230772C112705442 @default.
- W4387230772 hasConceptScore W4387230772C126322002 @default.
- W4387230772 hasConceptScore W4387230772C2777138892 @default.
- W4387230772 hasConceptScore W4387230772C2777288759 @default.
- W4387230772 hasConceptScore W4387230772C2778260677 @default.
- W4387230772 hasConceptScore W4387230772C2779134260 @default.
- W4387230772 hasConceptScore W4387230772C2779280984 @default.
- W4387230772 hasConceptScore W4387230772C71924100 @default.
- W4387230772 hasConceptScore W4387230772C90924648 @default.
- W4387230772 hasConceptScore W4387230772C98274493 @default.
- W4387230772 hasIssue "10" @default.
- W4387230772 hasLocation W43872307721 @default.
- W4387230772 hasOpenAccess W4387230772 @default.
- W4387230772 hasPrimaryLocation W43872307721 @default.
- W4387230772 hasRelatedWork W1897160555 @default.
- W4387230772 hasRelatedWork W2000293965 @default.
- W4387230772 hasRelatedWork W2072640801 @default.
- W4387230772 hasRelatedWork W2093504865 @default.
- W4387230772 hasRelatedWork W2133832905 @default.
- W4387230772 hasRelatedWork W2409753288 @default.
- W4387230772 hasRelatedWork W2915644342 @default.
- W4387230772 hasRelatedWork W3166797618 @default.
- W4387230772 hasRelatedWork W4210913627 @default.
- W4387230772 hasRelatedWork W4251398023 @default.
- W4387230772 hasVolume "15" @default.
- W4387230772 isParatext "false" @default.
- W4387230772 isRetracted "false" @default.
- W4387230772 workType "article" @default.