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- W4387233082 endingPage "114387" @default.
- W4387233082 startingPage "114387" @default.
- W4387233082 abstract "Stressors in the environment of aquatic organisms can profoundly affect their immune system. The stress response in fish involves the activation of the hypothalamus-pituitary-interrenal (HPI) axis, leading to the release of several stress hormones, among them glucocorticoids, such as cortisol, which bind and activate corticosteroid receptors, namely the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). These receptors are highly expressed on immune cells, thereby allowing stress to have a potent effect that is classically considered to suppress immune function. In this review, we highlight the conserved structure and function of GR and MR among vertebrates and describe their role in modulating inflammation by regulating the expression of pro-inflammatory and anti-inflammatory genes. In particular, the involvement of MR during inflammation is reviewed, which in many studies has been shown to be immune-enhancing. In recent years, the use of zebrafish as a model organism has opened up new possibilities to study the effects of stress on inflammation, making it possible to investigate knockout lines for MR and/or GR, in combination with transgenic models with fluorescently labeled leukocyte subpopulations that enable the visualization and manipulation of these immune cells. The potential roles of other hormones of the HPI axis, such as corticotrophin-releasing hormone (Crh) and adrenocorticotropic hormone (Acth), in immune modulation are also discussed. Overall, this review highlights the need for further research to elucidate the specific roles of GR, MR and other stress hormones in regulating immune function in fish. Understanding these mechanisms will contribute to improving fish health and advancing our knowledge of stress signalling." @default.
- W4387233082 created "2023-10-02" @default.
- W4387233082 creator A5022892166 @default.
- W4387233082 creator A5083997372 @default.
- W4387233082 date "2024-01-01" @default.
- W4387233082 modified "2023-10-09" @default.
- W4387233082 title "Molecular mechanisms of the stress-induced regulation of the inflammatory response in fish" @default.
- W4387233082 cites W1602000534 @default.
- W4387233082 cites W1634810315 @default.
- W4387233082 cites W1818981310 @default.
- W4387233082 cites W1882508453 @default.
- W4387233082 cites W1902327912 @default.
- W4387233082 cites W1907954732 @default.
- W4387233082 cites W1909584560 @default.
- W4387233082 cites W1974742102 @default.
- W4387233082 cites W1978378281 @default.
- W4387233082 cites W1983691372 @default.
- W4387233082 cites W1988909210 @default.
- W4387233082 cites W1994042575 @default.
- W4387233082 cites W2006588648 @default.
- W4387233082 cites W2008409819 @default.
- W4387233082 cites W2008654807 @default.
- W4387233082 cites W2016870566 @default.
- W4387233082 cites W2021708267 @default.
- W4387233082 cites W2025175138 @default.
- W4387233082 cites W2047035225 @default.
- W4387233082 cites W2050195517 @default.
- W4387233082 cites W2055716241 @default.
- W4387233082 cites W2061740109 @default.
- W4387233082 cites W2068246413 @default.
- W4387233082 cites W2072812592 @default.
- W4387233082 cites W2076597255 @default.
- W4387233082 cites W2081891489 @default.
- W4387233082 cites W2082384866 @default.
- W4387233082 cites W2089248014 @default.
- W4387233082 cites W2092299372 @default.
- W4387233082 cites W2109458697 @default.
- W4387233082 cites W2124823000 @default.
- W4387233082 cites W2136061619 @default.
- W4387233082 cites W2145334570 @default.
- W4387233082 cites W2146518252 @default.
- W4387233082 cites W2161369618 @default.
- W4387233082 cites W2171512984 @default.
- W4387233082 cites W2275516353 @default.
- W4387233082 cites W2335779548 @default.
- W4387233082 cites W2406124884 @default.
- W4387233082 cites W2468132108 @default.
- W4387233082 cites W2478372181 @default.
- W4387233082 cites W2478730098 @default.
- W4387233082 cites W2546663330 @default.
- W4387233082 cites W2548145684 @default.
- W4387233082 cites W2549673708 @default.
- W4387233082 cites W2553841243 @default.
- W4387233082 cites W2557407637 @default.
- W4387233082 cites W2562892645 @default.
- W4387233082 cites W2589611314 @default.
- W4387233082 cites W2610903647 @default.
- W4387233082 cites W2649865612 @default.
- W4387233082 cites W2735750824 @default.
- W4387233082 cites W2742784686 @default.
- W4387233082 cites W2752469080 @default.
- W4387233082 cites W2753518299 @default.
- W4387233082 cites W2762029453 @default.
- W4387233082 cites W2774810997 @default.
- W4387233082 cites W2796110790 @default.
- W4387233082 cites W2800654096 @default.
- W4387233082 cites W2887625843 @default.
- W4387233082 cites W2892971962 @default.
- W4387233082 cites W2906506916 @default.
- W4387233082 cites W2908501762 @default.
- W4387233082 cites W2953903869 @default.
- W4387233082 cites W2969167159 @default.
- W4387233082 cites W2982689855 @default.
- W4387233082 cites W3000502359 @default.
- W4387233082 cites W3020830575 @default.
- W4387233082 cites W3021489030 @default.
- W4387233082 cites W3041555636 @default.
- W4387233082 cites W3085728080 @default.
- W4387233082 cites W3092270521 @default.
- W4387233082 cites W3107797020 @default.
- W4387233082 cites W3112776982 @default.
- W4387233082 cites W3118354246 @default.
- W4387233082 cites W3124917029 @default.
- W4387233082 cites W3157106227 @default.
- W4387233082 cites W3157108153 @default.
- W4387233082 cites W3160100186 @default.
- W4387233082 cites W3177420026 @default.
- W4387233082 cites W4200015790 @default.
- W4387233082 cites W4200335660 @default.
- W4387233082 cites W4206548934 @default.
- W4387233082 cites W4210879428 @default.
- W4387233082 cites W4214661559 @default.
- W4387233082 cites W4221006990 @default.
- W4387233082 cites W4290643168 @default.
- W4387233082 cites W4293701397 @default.
- W4387233082 cites W4308266305 @default.
- W4387233082 cites W4384283376 @default.
- W4387233082 cites W4385997559 @default.