Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387233445> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4387233445 abstract "Background Various local drug delivery systems have been tried so far to target microorganisms responsible for periodontitis. However, none of them were effective enough to destroy the periodontal pathogens. This study aimed to analyze the antimicrobial, antioxidant, and anti-inflammatory properties of melatonin-loaded, calcium oxide nanoparticles-based neem and clove extract against oral pathogens to be further used as a local delivery agent. Methodology Powdered fresh neem leaves and clove buds were weighed, added to double distilled water, and then boiled for half an hour. Boiling helps in activating the phytochemicals present in the extract. The solution was boiled further to obtain a concentrated solution. To this 0.241 g of melatonin powder dissolved in 10 mL of double distilled water was added to the previous mixture and left undisturbed in a stirrer overnight. Results The properties of the extract such as antioxidant, antibacterial, anti-inflammatory, cytotoxicity, and embryonic toxicology were studied. In the case of antimicrobial activity, at 100 μg/mL, the zone of inhibition (ZOI) was the highest at 18 ± 0.16 μg/mL and the lowest at 13 ± 0.3 at 25 μg/mL for Candida albicans. Similarly, at 100 μg/mL, the ZOI was the highest at 15 ± 0.25 μg/mL and the lowest was 13 ± 0.12 at 25 μg/mL for Streptococcus mutans and Staphylococcus aureus. Similarly, in the case of antioxidant and anti-inflammatory properties, they showed increased activity with increased concentrations of 10, 20, 30, 40, and 50 μg/mL. Conclusions This study proves that melatonin-added extracts have antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties which are almost equal to that of the standard. This indicates that they can be possibly further used as local delivery drugs. Further animal or cell line studies should be conducted before experimenting this is in clinical trials for periodontitis patients." @default.
- W4387233445 created "2023-10-02" @default.
- W4387233445 creator A5016600933 @default.
- W4387233445 creator A5054657360 @default.
- W4387233445 creator A5081980718 @default.
- W4387233445 date "2023-09-30" @default.
- W4387233445 modified "2023-10-16" @default.
- W4387233445 title "The Development and Evaluation of Melatonin-Loaded, Calcium Oxide Nanoparticle-Based Neem and Clove Extract: An In Vitro Study" @default.
- W4387233445 cites W1762827693 @default.
- W4387233445 cites W2001725777 @default.
- W4387233445 cites W2049953485 @default.
- W4387233445 cites W2050445378 @default.
- W4387233445 cites W2073061446 @default.
- W4387233445 cites W2074571595 @default.
- W4387233445 cites W2108324127 @default.
- W4387233445 cites W2124602788 @default.
- W4387233445 cites W2606203795 @default.
- W4387233445 cites W2901686656 @default.
- W4387233445 cites W2910724188 @default.
- W4387233445 cites W2952984514 @default.
- W4387233445 cites W3004209485 @default.
- W4387233445 cites W3049317096 @default.
- W4387233445 cites W3093179161 @default.
- W4387233445 cites W3110567601 @default.
- W4387233445 cites W3120202666 @default.
- W4387233445 cites W3159098189 @default.
- W4387233445 cites W3187604887 @default.
- W4387233445 cites W4210643707 @default.
- W4387233445 cites W4285392498 @default.
- W4387233445 cites W4298396102 @default.
- W4387233445 cites W4309713341 @default.
- W4387233445 cites W4376621628 @default.
- W4387233445 doi "https://doi.org/10.7759/cureus.46293" @default.
- W4387233445 hasPublicationYear "2023" @default.
- W4387233445 type Work @default.
- W4387233445 citedByCount "0" @default.
- W4387233445 crossrefType "journal-article" @default.
- W4387233445 hasAuthorship W4387233445A5016600933 @default.
- W4387233445 hasAuthorship W4387233445A5054657360 @default.
- W4387233445 hasAuthorship W4387233445A5081980718 @default.
- W4387233445 hasBestOaLocation W43872334451 @default.
- W4387233445 hasConcept C126322002 @default.
- W4387233445 hasConcept C185592680 @default.
- W4387233445 hasConcept C199343813 @default.
- W4387233445 hasConcept C2777084678 @default.
- W4387233445 hasConcept C2778004101 @default.
- W4387233445 hasConcept C2778182776 @default.
- W4387233445 hasConcept C2778430296 @default.
- W4387233445 hasConcept C2779429693 @default.
- W4387233445 hasConcept C2779489039 @default.
- W4387233445 hasConcept C2780104969 @default.
- W4387233445 hasConcept C2780917455 @default.
- W4387233445 hasConcept C31903555 @default.
- W4387233445 hasConcept C43617362 @default.
- W4387233445 hasConcept C4937899 @default.
- W4387233445 hasConcept C523546767 @default.
- W4387233445 hasConcept C54355233 @default.
- W4387233445 hasConcept C55493867 @default.
- W4387233445 hasConcept C556039675 @default.
- W4387233445 hasConcept C71924100 @default.
- W4387233445 hasConcept C86803240 @default.
- W4387233445 hasConcept C89423630 @default.
- W4387233445 hasConceptScore W4387233445C126322002 @default.
- W4387233445 hasConceptScore W4387233445C185592680 @default.
- W4387233445 hasConceptScore W4387233445C199343813 @default.
- W4387233445 hasConceptScore W4387233445C2777084678 @default.
- W4387233445 hasConceptScore W4387233445C2778004101 @default.
- W4387233445 hasConceptScore W4387233445C2778182776 @default.
- W4387233445 hasConceptScore W4387233445C2778430296 @default.
- W4387233445 hasConceptScore W4387233445C2779429693 @default.
- W4387233445 hasConceptScore W4387233445C2779489039 @default.
- W4387233445 hasConceptScore W4387233445C2780104969 @default.
- W4387233445 hasConceptScore W4387233445C2780917455 @default.
- W4387233445 hasConceptScore W4387233445C31903555 @default.
- W4387233445 hasConceptScore W4387233445C43617362 @default.
- W4387233445 hasConceptScore W4387233445C4937899 @default.
- W4387233445 hasConceptScore W4387233445C523546767 @default.
- W4387233445 hasConceptScore W4387233445C54355233 @default.
- W4387233445 hasConceptScore W4387233445C55493867 @default.
- W4387233445 hasConceptScore W4387233445C556039675 @default.
- W4387233445 hasConceptScore W4387233445C71924100 @default.
- W4387233445 hasConceptScore W4387233445C86803240 @default.
- W4387233445 hasConceptScore W4387233445C89423630 @default.
- W4387233445 hasLocation W43872334451 @default.
- W4387233445 hasOpenAccess W4387233445 @default.
- W4387233445 hasPrimaryLocation W43872334451 @default.
- W4387233445 hasRelatedWork W1231317471 @default.
- W4387233445 hasRelatedWork W2011014959 @default.
- W4387233445 hasRelatedWork W2083826861 @default.
- W4387233445 hasRelatedWork W2140839919 @default.
- W4387233445 hasRelatedWork W2289444717 @default.
- W4387233445 hasRelatedWork W2313866449 @default.
- W4387233445 hasRelatedWork W2418863638 @default.
- W4387233445 hasRelatedWork W2479672999 @default.
- W4387233445 hasRelatedWork W2770185532 @default.
- W4387233445 hasRelatedWork W4309580480 @default.
- W4387233445 isParatext "false" @default.
- W4387233445 isRetracted "false" @default.
- W4387233445 workType "article" @default.