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• W4387233997 abstract "Cancer is a heterogeneous disease that demands precise molecular profiling for better understanding and management. RNA-sequencing has emerged as a potent tool to unravel the transcriptional heterogeneity. However, large-scale characterization of cancer transcriptomes is hindered by the limitations of costs and tissue accessibility. Here, we develop SEQUOIA , a deep learning model employing a transformer architecture to predict cancer transcriptomes from whole-slide histology images. We pre-train the model using data from 2,242 normal tissues, and the model is fine-tuned and evaluated in 4,218 tumor samples across nine cancer types. The results are further validated across two independent cohorts compromising 1,305 tumors. The highest performance was observed in cancers from breast, kidney and lung, where SEQUOIA accurately predicted 13,798, 10,922 and 9,735 genes, respectively. The well predicted genes are associated with the regulation of inflammatory response, cell cycles and hypoxia-related metabolic pathways. Leveraging the well predicted genes, we develop a digital signature to predict the risk of recurrence in breast cancer. While the model is trained at the tissue-level, we showcase its potential in predicting spatial gene expression patterns using spatial transcriptomics datasets. SEQUOIA deciphers clinically relevant gene expression patterns from histology images, opening avenues for improved cancer management and personalized therapies." @default.
• W4387233997 created "2023-10-02" @default.
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• W4387233997 date "2023-09-30" @default.
• W4387233997 modified "2023-10-18" @default.
• W4387233997 title "Digital profiling of cancer transcriptomes from histology images with grouped vision attention" @default.
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• W4387233997 doi "https://doi.org/10.1101/2023.09.28.560068" @default.
• W4387233997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37808782" @default.
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