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- W4387234194 abstract "ABSTRACT The shoot apical meristem (SAM) gives rise to above-ground organs. The size of the SAM is relatively constant due to the balance of stem cell replenishment versus cell recruitment into developing organs. In angiosperms, the transcription factor WUSCHEL (WUS) promotes stem cell identity in the central zone of the SAM. WUS forms a negative feedback loop with a signaling pathway activated by CLAVATA3 (CLV3). In the periphery of the SAM, the ERECTA family (ERf) receptors promote cell differentiation and constrain the expression of WUS and CLV3 . Here, we show that four ligands of ERfs redundantly inhibit CLV3 and WUS expression. Transcriptome analysis confirmed that WUS and CLV3 are the main targets of ERf signaling and uncovered several new ones. Analysis of promoter reporters indicated that in the vegetative meristem, the WUS expression domain mostly overlapped with the CLV3 domain and did not shift along the apical-basal axis in clv3 . A 3D mathematical model reproduced the experimentally observed CLV3 and WUS expression patterns with fewer assumptions than earlier models. Based on these findings, we propose that CLV3 regulates cellular levels of WUS expression through autocrine signaling, while ERfs regulate WUS spatial expression, preventing its encroachment into the peripheral zone. One Sentence Summary Through autocrine signaling, CLV3 regulates the level of WUS expression in the vegetative SAM but not its location, while ERfs regulate the WUS spatial pattern, preventing its expansion into the peripheral zone." @default.
- W4387234194 created "2023-10-02" @default.
- W4387234194 creator A5003369711 @default.
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- W4387234194 creator A5092495214 @default.
- W4387234194 date "2023-09-30" @default.
- W4387234194 modified "2023-10-16" @default.
- W4387234194 title "An updated model of shoot apical meristem regulation by ERECTA family and CLAVATA3 signaling pathways" @default.
- W4387234194 cites W1593061023 @default.
- W4387234194 cites W1660478336 @default.
- W4387234194 cites W1930694361 @default.
- W4387234194 cites W1971577828 @default.
- W4387234194 cites W1972979571 @default.
- W4387234194 cites W1973347589 @default.
- W4387234194 cites W1987384599 @default.
- W4387234194 cites W1988583633 @default.
- W4387234194 cites W1989039494 @default.
- W4387234194 cites W1989726653 @default.
- W4387234194 cites W1997880056 @default.
- W4387234194 cites W2005892352 @default.
- W4387234194 cites W2005936528 @default.
- W4387234194 cites W2010473840 @default.
- W4387234194 cites W2015187385 @default.
- W4387234194 cites W2019505101 @default.
- W4387234194 cites W2023230492 @default.
- W4387234194 cites W2031068380 @default.
- W4387234194 cites W2037353000 @default.
- W4387234194 cites W2044632008 @default.
- W4387234194 cites W2046277338 @default.
- W4387234194 cites W2046438125 @default.
- W4387234194 cites W2055490547 @default.
- W4387234194 cites W2056653726 @default.
- W4387234194 cites W2061308466 @default.
- W4387234194 cites W2072638141 @default.
- W4387234194 cites W2084910946 @default.
- W4387234194 cites W2088410574 @default.
- W4387234194 cites W2089888337 @default.
- W4387234194 cites W2090850845 @default.
- W4387234194 cites W2091567597 @default.
- W4387234194 cites W2095117713 @default.
- W4387234194 cites W2097098783 @default.
- W4387234194 cites W2104571271 @default.
- W4387234194 cites W2107523377 @default.
- W4387234194 cites W2114183050 @default.
- W4387234194 cites W2118923997 @default.
- W4387234194 cites W2125661440 @default.
- W4387234194 cites W2134304740 @default.
- W4387234194 cites W2135202770 @default.
- W4387234194 cites W2137586531 @default.
- W4387234194 cites W2138207763 @default.
- W4387234194 cites W2139330928 @default.
- W4387234194 cites W2142468991 @default.
- W4387234194 cites W2144817330 @default.
- W4387234194 cites W2151155840 @default.
- W4387234194 cites W2156413023 @default.
- W4387234194 cites W2158225003 @default.
- W4387234194 cites W2160204546 @default.
- W4387234194 cites W2161060432 @default.
- W4387234194 cites W2164528584 @default.
- W4387234194 cites W2165270868 @default.
- W4387234194 cites W2169393691 @default.
- W4387234194 cites W2169456326 @default.
- W4387234194 cites W2179438025 @default.
- W4387234194 cites W2228103413 @default.
- W4387234194 cites W2262730545 @default.
- W4387234194 cites W2349610147 @default.
- W4387234194 cites W2517220001 @default.
- W4387234194 cites W2524432326 @default.
- W4387234194 cites W2593572167 @default.
- W4387234194 cites W2605310505 @default.
- W4387234194 cites W2620680560 @default.
- W4387234194 cites W2784319824 @default.
- W4387234194 cites W2794850753 @default.
- W4387234194 cites W2800352028 @default.
- W4387234194 cites W2884300959 @default.
- W4387234194 cites W2886491129 @default.
- W4387234194 cites W2889211873 @default.
- W4387234194 cites W2898174520 @default.
- W4387234194 cites W2900390098 @default.
- W4387234194 cites W2946521719 @default.
- W4387234194 cites W2949830473 @default.
- W4387234194 cites W2991206097 @default.
- W4387234194 cites W3086329401 @default.
- W4387234194 cites W3107405110 @default.
- W4387234194 cites W3129617248 @default.
- W4387234194 cites W3199304241 @default.
- W4387234194 cites W3203222962 @default.
- W4387234194 cites W4253676973 @default.
- W4387234194 cites W4282968641 @default.
- W4387234194 cites W4283734939 @default.
- W4387234194 cites W4293199514 @default.
- W4387234194 cites W4309859682 @default.
- W4387234194 cites W4320032713 @default.
- W4387234194 cites W4376286418 @default.