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- W4387241330 abstract "The process of ovarian cryopreservation and transplantation is the only feasible fertility preservation method for prepubertal girls and female patients with cancer who cannot delay radiotherapy and chemotherapy. However, basic research on this technique is lacking. To better understand ovarian function and oocyte quality after ovarian tissue (OT) transplantation, we characterised the appearance, angiogenesis, and endocrine function of ovarian grafts in a murine model; the mitochondrial function and DNA damage in oocytes isolated from the OT; and the development of embryos after in vitro fertilisation. The results showed a decrease in oocyte numbers in the transplanted OT, abnormal endocrine function of ovarian grafts, as well as dysfunctional mitochondria and DNA damage in the oocytes, which could adversely affect subsequent embryonic development. However, these adverse phenotypes were partially or completely resolved within 21 days of transplantation, suggesting that ovulation induction and assisted pregnancy treatment should not be conducted too soon after OT transfer to ensure optimal patient and offspring outcomes." @default.
- W4387241330 created "2023-10-03" @default.
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- W4387241330 date "2023-10-02" @default.
- W4387241330 modified "2023-10-03" @default.
- W4387241330 title "Adverse Effects of Ovarian Cryopreservation and Auto-transplantation on Ovarian Grafts and Quality of Produced Oocytes in a Mouse Model" @default.
- W4387241330 doi "https://doi.org/10.1042/cs20230483" @default.
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