Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387241377> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4387241377 abstract "The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the current worldwide pandemic and the associated coronavirus disease 2019 with potentially lethal outcome. Although effective vaccines strongly contributed to reduce disease severity, establishing a toolbox to control current and newly emerging coronaviruses of epidemic concern requires the development of novel therapeutic compounds, to treat severely infected individuals and to prevent virus transmission. Here we present a therapeutic strategy targeting the SARS-CoV-2 RNA genome using antisense oligonucleotides (ASOs). We demonstrate that selected locked nucleic acid gapmers have the potency to reduce the in vitro intracellular viral load by up to 96%. Our promising results strongly support the case for further development of our preselected ASOs as therapeutic or prophylactic antiviral agents." @default.
- W4387241377 created "2023-10-03" @default.
- W4387241377 creator A5003051464 @default.
- W4387241377 creator A5003781553 @default.
- W4387241377 creator A5010959513 @default.
- W4387241377 creator A5022031034 @default.
- W4387241377 creator A5027909548 @default.
- W4387241377 creator A5036764670 @default.
- W4387241377 creator A5078257437 @default.
- W4387241377 creator A5082948600 @default.
- W4387241377 date "2023-09-29" @default.
- W4387241377 modified "2023-10-03" @default.
- W4387241377 title "Highly Potent Antisense Oligonucleotides Locked Nucleic Acid Gapmers Targeting the SARS-CoV-2 RNA Genome" @default.
- W4387241377 cites W1982559408 @default.
- W4387241377 cites W2006167464 @default.
- W4387241377 cites W2442594675 @default.
- W4387241377 cites W2517601456 @default.
- W4387241377 cites W2772685483 @default.
- W4387241377 cites W3004280078 @default.
- W4387241377 cites W3034335935 @default.
- W4387241377 cites W3040711686 @default.
- W4387241377 cites W3084236163 @default.
- W4387241377 cites W3098049011 @default.
- W4387241377 cites W3116376362 @default.
- W4387241377 cites W3130346995 @default.
- W4387241377 cites W3130817332 @default.
- W4387241377 cites W3130830364 @default.
- W4387241377 cites W3160304872 @default.
- W4387241377 cites W4200317975 @default.
- W4387241377 cites W4205795293 @default.
- W4387241377 cites W4226148899 @default.
- W4387241377 cites W4241090182 @default.
- W4387241377 cites W4289549951 @default.
- W4387241377 cites W4296449874 @default.
- W4387241377 cites W4323656766 @default.
- W4387241377 doi "https://doi.org/10.1089/nat.2023.0012" @default.
- W4387241377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37782140" @default.
- W4387241377 hasPublicationYear "2023" @default.
- W4387241377 type Work @default.
- W4387241377 citedByCount "0" @default.
- W4387241377 crossrefType "journal-article" @default.
- W4387241377 hasAuthorship W4387241377A5003051464 @default.
- W4387241377 hasAuthorship W4387241377A5003781553 @default.
- W4387241377 hasAuthorship W4387241377A5010959513 @default.
- W4387241377 hasAuthorship W4387241377A5022031034 @default.
- W4387241377 hasAuthorship W4387241377A5027909548 @default.
- W4387241377 hasAuthorship W4387241377A5036764670 @default.
- W4387241377 hasAuthorship W4387241377A5078257437 @default.
- W4387241377 hasAuthorship W4387241377A5082948600 @default.
- W4387241377 hasConcept C104317684 @default.
- W4387241377 hasConcept C129312508 @default.
- W4387241377 hasConcept C141231307 @default.
- W4387241377 hasConcept C142724271 @default.
- W4387241377 hasConcept C14363569 @default.
- W4387241377 hasConcept C159047783 @default.
- W4387241377 hasConcept C24107716 @default.
- W4387241377 hasConcept C2522874641 @default.
- W4387241377 hasConcept C2777648638 @default.
- W4387241377 hasConcept C2779134260 @default.
- W4387241377 hasConcept C3008058167 @default.
- W4387241377 hasConcept C524204448 @default.
- W4387241377 hasConcept C54355233 @default.
- W4387241377 hasConcept C67705224 @default.
- W4387241377 hasConcept C70721500 @default.
- W4387241377 hasConcept C71924100 @default.
- W4387241377 hasConcept C86803240 @default.
- W4387241377 hasConceptScore W4387241377C104317684 @default.
- W4387241377 hasConceptScore W4387241377C129312508 @default.
- W4387241377 hasConceptScore W4387241377C141231307 @default.
- W4387241377 hasConceptScore W4387241377C142724271 @default.
- W4387241377 hasConceptScore W4387241377C14363569 @default.
- W4387241377 hasConceptScore W4387241377C159047783 @default.
- W4387241377 hasConceptScore W4387241377C24107716 @default.
- W4387241377 hasConceptScore W4387241377C2522874641 @default.
- W4387241377 hasConceptScore W4387241377C2777648638 @default.
- W4387241377 hasConceptScore W4387241377C2779134260 @default.
- W4387241377 hasConceptScore W4387241377C3008058167 @default.
- W4387241377 hasConceptScore W4387241377C524204448 @default.
- W4387241377 hasConceptScore W4387241377C54355233 @default.
- W4387241377 hasConceptScore W4387241377C67705224 @default.
- W4387241377 hasConceptScore W4387241377C70721500 @default.
- W4387241377 hasConceptScore W4387241377C71924100 @default.
- W4387241377 hasConceptScore W4387241377C86803240 @default.
- W4387241377 hasLocation W43872413771 @default.
- W4387241377 hasLocation W43872413772 @default.
- W4387241377 hasOpenAccess W4387241377 @default.
- W4387241377 hasPrimaryLocation W43872413771 @default.
- W4387241377 hasRelatedWork W1989350280 @default.
- W4387241377 hasRelatedWork W1998666145 @default.
- W4387241377 hasRelatedWork W2003518972 @default.
- W4387241377 hasRelatedWork W2077237334 @default.
- W4387241377 hasRelatedWork W2084804290 @default.
- W4387241377 hasRelatedWork W2139273728 @default.
- W4387241377 hasRelatedWork W2162283955 @default.
- W4387241377 hasRelatedWork W2322955507 @default.
- W4387241377 hasRelatedWork W2337168985 @default.
- W4387241377 hasRelatedWork W3179597092 @default.
- W4387241377 isParatext "false" @default.
- W4387241377 isRetracted "false" @default.
- W4387241377 workType "article" @default.