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• W4387241428 abstract "Abstract Gliomas account for 50% of brain cancers and are therefore the most common brain tumors. Molecular alterations involved in adult gliomas have been identified and mainly affect tyrosine kinase receptors with amplification and/or mutation of the epidermal growth factor receptor (EGFR) and its associated signaling pathways. Several targeted therapies have been developed, but current treatments remain ineffective for glioblastomas, the most severe forms. Thus, it is a priority to identify new pharmacological targets. Drosophila glioma models established in larvae and adults are useful to identify new genes and signaling pathways involved in glioma progression. Here, we used a Drosophila glioma model in adults, to characterize metabolic disturbances associated with glioma and assess the consequences of 5‐HT 7 R expression on glioma development. First, by using in vivo magnetic resonance imaging, we have shown that expression of the constitutively active forms of EGFR and PI3K in adult glial cells induces brain enlargement. Then, we explored altered cellular metabolism by using high‐resolution magic angle spinning NMR and 1 H‐ 13 C heteronuclear single quantum coherence solution states. Discriminant metabolites identified highlight the rewiring of metabolic pathways in glioma and associated cachexia phenotypes. Finally, the expression of 5‐HT 7 R in this adult model attenuates phenotypes associated with glioma development. Collectively, this whole‐animal approach in Drosophila allowed us to provide several rapid and robust phenotype readouts, such as enlarged brain volume and glioma‐associated cachexia, as well as to determine the metabolic pathways involved in glioma genesis and finally to confirm the interest of the 5‐HT 7 R in the treatment of glioma." @default.
• W4387241428 created "2023-10-03" @default.
• W4387241428 creator A5031674174 @default.
• W4387241428 creator A5037135784 @default.
• W4387241428 creator A5041640317 @default.
• W4387241428 creator A5045630788 @default.
• W4387241428 creator A5072392864 @default.
• W4387241428 creator A5072801779 @default.
• W4387241428 creator A5075690711 @default.
• W4387241428 date "2023-10-02" @default.
• W4387241428 modified "2023-10-04" @default.
• W4387241428 title "An adult <i>Drosophila</i> glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin <scp>5‐HT₇</scp> receptor as a potential therapeutic target" @default.
• W4387241428 cites W1558704041 @default.
• W4387241428 cites W1667881669 @default.
• W4387241428 cites W1675124236 @default.
• W4387241428 cites W1878712355 @default.
• W4387241428 cites W1969512492 @default.
• W4387241428 cites W1973767788 @default.
• W4387241428 cites W1984621921 @default.
• W4387241428 cites W1985113471 @default.
• W4387241428 cites W1987665116 @default.
• W4387241428 cites W1992524428 @default.
• W4387241428 cites W1998224093 @default.
• W4387241428 cites W2000926872 @default.
• W4387241428 cites W2008869575 @default.
• W4387241428 cites W2012355682 @default.
• W4387241428 cites W2012729430 @default.
• W4387241428 cites W2014192696 @default.
• W4387241428 cites W2017439745 @default.
• W4387241428 cites W2019683289 @default.
• W4387241428 cites W2020950228 @default.
• W4387241428 cites W2021447278 @default.
• W4387241428 cites W2021743398 @default.
• W4387241428 cites W2022101765 @default.
• W4387241428 cites W2025183726 @default.
• W4387241428 cites W2028104467 @default.
• W4387241428 cites W2028554313 @default.
• W4387241428 cites W2029219396 @default.
• W4387241428 cites W2029862112 @default.
• W4387241428 cites W2034127653 @default.
• W4387241428 cites W2036681193 @default.
• W4387241428 cites W2039295111 @default.
• W4387241428 cites W2044018324 @default.
• W4387241428 cites W2046733360 @default.
• W4387241428 cites W2048899027 @default.
• W4387241428 cites W2049741320 @default.
• W4387241428 cites W2050031113 @default.
• W4387241428 cites W2051257252 @default.
• W4387241428 cites W2052551989 @default.
• W4387241428 cites W2053363717 @default.
• W4387241428 cites W2053518500 @default.
• W4387241428 cites W2054823164 @default.
• W4387241428 cites W2056558785 @default.
• W4387241428 cites W2061992609 @default.
• W4387241428 cites W2064003847 @default.
• W4387241428 cites W2064669765 @default.
• W4387241428 cites W2066528197 @default.
• W4387241428 cites W2068915942 @default.
• W4387241428 cites W2072451938 @default.
• W4387241428 cites W2078809426 @default.
• W4387241428 cites W2085322703 @default.
• W4387241428 cites W2085483616 @default.
• W4387241428 cites W2095999479 @default.
• W4387241428 cites W2101093124 @default.
• W4387241428 cites W2101781016 @default.
• W4387241428 cites W2104479723 @default.
• W4387241428 cites W2105348749 @default.
• W4387241428 cites W2108488321 @default.
• W4387241428 cites W2114998237 @default.
• W4387241428 cites W2117776962 @default.
• W4387241428 cites W2121425914 @default.
• W4387241428 cites W2124047443 @default.
• W4387241428 cites W2130906350 @default.
• W4387241428 cites W2131802378 @default.
• W4387241428 cites W2132550409 @default.
• W4387241428 cites W2138872672 @default.
• W4387241428 cites W2145152682 @default.
• W4387241428 cites W2145280166 @default.
• W4387241428 cites W2150681879 @default.
• W4387241428 cites W2151283204 @default.
• W4387241428 cites W2151335185 @default.
• W4387241428 cites W2155680682 @default.
• W4387241428 cites W2160382843 @default.
• W4387241428 cites W2162921620 @default.
• W4387241428 cites W2163093080 @default.
• W4387241428 cites W2171588919 @default.
• W4387241428 cites W2276029722 @default.
• W4387241428 cites W2290638097 @default.
• W4387241428 cites W2410386040 @default.
• W4387241428 cites W2473591635 @default.
• W4387241428 cites W2534904302 @default.
• W4387241428 cites W2550325521 @default.
• W4387241428 cites W2570057121 @default.
• W4387241428 cites W2582878148 @default.
• W4387241428 cites W2596977749 @default.
• W4387241428 cites W2607640564 @default.
• W4387241428 cites W2620159843 @default.
• W4387241428 cites W2735452220 @default.
• W4387241428 cites W2788825876 @default.
• W4387241428 cites W2791486327 @default.

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