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• W4387241925 abstract "A GII.2 outbreak in an efficacy study of a bivalent virus-like particle (VLP) norovirus vaccine, TAK-214, in healthy US adults provided an opportunity to examine GII.4 homotypic vs. GII.2 heterotypic responses to vaccination and infection. Three serological assays (VLP-binding, histoblood group antigen-blocking, and neutralizing) were performed for each genotype. Results were highly correlated within a genotype but not between genotypes. Although the vaccine provided protection from GII.2-associated disease, little GII.2-specific neutralization occurred after vaccination. Choice of antibody assay can affect assessments of human norovirus vaccine immunogenicity." @default.
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• W4387241925 date "2023-10-02" @default.
• W4387241925 modified "2023-10-09" @default.
• W4387241925 title "A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies" @default.
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• W4387241925 doi "https://doi.org/10.1093/infdis/jiad401" @default.
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