Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387242130> ?p ?o ?g. }
- W4387242130 abstract "Patients with idiopathic normal-pressure hydrocephalus (iNPH) can show a global reduction in cerebral glucose metabolism at [18F]Fluorodeoxyglucose (FDG) PET. The presence of caudate hypometabolism has been identified as a potential biomarker in iNPH, yet there is limited evidence of hypermetabolic findings in patients with iNPH so far.We retrieved retrospectively patients with iNPH and normal cognitive assessment, evaluated before surgery undergoing brain [18F]FDG-PET. The 18F-FDG-PET brain scans were compared to those of a control group of healthy subjects, matched for age and sex, by statistical parametric mapping (SPM) to identify areas of relative hypo- and hypermetabolism. Furthermore, the existence of a correlation between areas of hypo- and hypermetabolism in the patient group was tested.Seven iNPH patients (mean age 74 ± 6 years) were found in the hospital database. SPM group analysis revealed clusters of significant hypometabolism (P = 0.001) in the iNPH group in the dorsal striatum, involving caudate and putamen bilaterally. Clusters of significant hypermetabolism (P = 0.001) were revealed in the bilateral superior and precentral frontal gyrus (BA 4, 6). A significant inverse correlation between striatal hypometabolism and bilateral superior and precentral frontal gyrus hypermetabolism was revealed (P < 0.001 corrected for multiple comparisons).In this cohort, patients with iNPH showed subcortical hypometabolism, including bilateral dorsal striatum. To the best of our knowledge, this is the first report demonstrating a hypermetabolic pattern in the primary motor and premotor areas, and showing an inverse correlation between the striatum and motor cortex in patients with iNPH." @default.
- W4387242130 created "2023-10-03" @default.
- W4387242130 creator A5016447207 @default.
- W4387242130 creator A5017477138 @default.
- W4387242130 creator A5018495982 @default.
- W4387242130 creator A5032124589 @default.
- W4387242130 creator A5035404137 @default.
- W4387242130 creator A5040411250 @default.
- W4387242130 creator A5044901123 @default.
- W4387242130 creator A5047585580 @default.
- W4387242130 creator A5048110237 @default.
- W4387242130 creator A5053177676 @default.
- W4387242130 creator A5058243561 @default.
- W4387242130 creator A5064469387 @default.
- W4387242130 creator A5084538472 @default.
- W4387242130 creator A5086074681 @default.
- W4387242130 creator A5089013882 @default.
- W4387242130 date "2023-10-02" @default.
- W4387242130 modified "2023-10-03" @default.
- W4387242130 title "Brain positron emission tomography in idiopathic normal-pressure hydrocephalus: new 18F-fluorodeoxyglucose pattern in a long-known syndrome" @default.
- W4387242130 cites W2012505153 @default.
- W4387242130 cites W2015872829 @default.
- W4387242130 cites W2020070430 @default.
- W4387242130 cites W2028232332 @default.
- W4387242130 cites W2095309401 @default.
- W4387242130 cites W2133553639 @default.
- W4387242130 cites W2141763708 @default.
- W4387242130 cites W2142648440 @default.
- W4387242130 cites W2331747600 @default.
- W4387242130 cites W2462738213 @default.
- W4387242130 cites W2733208020 @default.
- W4387242130 cites W2751733957 @default.
- W4387242130 cites W2762740964 @default.
- W4387242130 cites W2783618237 @default.
- W4387242130 cites W2792718942 @default.
- W4387242130 cites W2807223386 @default.
- W4387242130 cites W2978750795 @default.
- W4387242130 cites W2994833810 @default.
- W4387242130 cites W2995211482 @default.
- W4387242130 cites W3010966623 @default.
- W4387242130 cites W3082996324 @default.
- W4387242130 cites W3083143481 @default.
- W4387242130 cites W3122065698 @default.
- W4387242130 cites W3181620419 @default.
- W4387242130 cites W4206212079 @default.
- W4387242130 doi "https://doi.org/10.1097/mnm.0000000000001763" @default.
- W4387242130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37779439" @default.
- W4387242130 hasPublicationYear "2023" @default.
- W4387242130 type Work @default.
- W4387242130 citedByCount "0" @default.
- W4387242130 crossrefType "journal-article" @default.
- W4387242130 hasAuthorship W4387242130A5016447207 @default.
- W4387242130 hasAuthorship W4387242130A5017477138 @default.
- W4387242130 hasAuthorship W4387242130A5018495982 @default.
- W4387242130 hasAuthorship W4387242130A5032124589 @default.
- W4387242130 hasAuthorship W4387242130A5035404137 @default.
- W4387242130 hasAuthorship W4387242130A5040411250 @default.
- W4387242130 hasAuthorship W4387242130A5044901123 @default.
- W4387242130 hasAuthorship W4387242130A5047585580 @default.
- W4387242130 hasAuthorship W4387242130A5048110237 @default.
- W4387242130 hasAuthorship W4387242130A5053177676 @default.
- W4387242130 hasAuthorship W4387242130A5058243561 @default.
- W4387242130 hasAuthorship W4387242130A5064469387 @default.
- W4387242130 hasAuthorship W4387242130A5084538472 @default.
- W4387242130 hasAuthorship W4387242130A5086074681 @default.
- W4387242130 hasAuthorship W4387242130A5089013882 @default.
- W4387242130 hasConcept C126322002 @default.
- W4387242130 hasConcept C126838900 @default.
- W4387242130 hasConcept C142724271 @default.
- W4387242130 hasConcept C143409427 @default.
- W4387242130 hasConcept C164705383 @default.
- W4387242130 hasConcept C2775842073 @default.
- W4387242130 hasConcept C2775956885 @default.
- W4387242130 hasConcept C2776286752 @default.
- W4387242130 hasConcept C2777464067 @default.
- W4387242130 hasConcept C2779714222 @default.
- W4387242130 hasConcept C2989005 @default.
- W4387242130 hasConcept C39313694 @default.
- W4387242130 hasConcept C71924100 @default.
- W4387242130 hasConceptScore W4387242130C126322002 @default.
- W4387242130 hasConceptScore W4387242130C126838900 @default.
- W4387242130 hasConceptScore W4387242130C142724271 @default.
- W4387242130 hasConceptScore W4387242130C143409427 @default.
- W4387242130 hasConceptScore W4387242130C164705383 @default.
- W4387242130 hasConceptScore W4387242130C2775842073 @default.
- W4387242130 hasConceptScore W4387242130C2775956885 @default.
- W4387242130 hasConceptScore W4387242130C2776286752 @default.
- W4387242130 hasConceptScore W4387242130C2777464067 @default.
- W4387242130 hasConceptScore W4387242130C2779714222 @default.
- W4387242130 hasConceptScore W4387242130C2989005 @default.
- W4387242130 hasConceptScore W4387242130C39313694 @default.
- W4387242130 hasConceptScore W4387242130C71924100 @default.
- W4387242130 hasLocation W43872421301 @default.
- W4387242130 hasLocation W43872421302 @default.
- W4387242130 hasOpenAccess W4387242130 @default.
- W4387242130 hasPrimaryLocation W43872421301 @default.
- W4387242130 hasRelatedWork W1969025484 @default.
- W4387242130 hasRelatedWork W1977496285 @default.
- W4387242130 hasRelatedWork W1991964129 @default.
- W4387242130 hasRelatedWork W2004928237 @default.