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• W4387244105 abstract "SUMMARY A single sensory cue can elicit diverse behavioral responses. For example, the taste of sugar robustly promotes feeding 1, 2 but also influences other behaviors, such as altering locomotor patterns to maximize food-finding 3, 4 or conferring a rewarding value onto associated contexts or cues. 5–7 Here, we investigate how sweet taste elicits multiple appetitive behaviors in Drosophila . Are different sugar-evoked behaviors coordinately regulated? At what point does the sugar circuit diverge into different pathways that drive distinct behaviors? We first established an optogenetic paradigm to study the effects of sugar taste on locomotion, spatial preference, and associative learning. We then tested how different sugar-evoked behaviors were modulated by internal and external factors, including hunger, diet, or the presence of an aversive taste. Different behaviors were generally modulated in similar ways, but we also observed some differences that reveal selective modulation of specific behavioral pathways. Finally, we investigated where the sugar taste circuit diverges into different behavioral pathways. A recent study identified a sensory-motor circuit comprising five layers of neurons that drives the initiation of feeding in response to sugar. 8 By individually manipulating each of these neurons, we show that circuits mediating different innate responses to sugar are partially overlapping and begin to diverge at the level of second- and third-order neurons, whereas circuits for innate versus learned behaviors may diverge at the first synapse. Connectomic analyses reveal distinct subcircuits that mediate different behaviors. Together, these studies provide insight into how neural circuits are organized to elicit diverse behavioral responses to a single stimulus." @default.
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• W4387244105 date "2023-10-02" @default.
• W4387244105 modified "2023-10-10" @default.
• W4387244105 title "Overlap and divergence of neural circuits mediating distinct behavioral responses to sugar" @default.
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• W4387244105 doi "https://doi.org/10.1101/2023.10.01.560401" @default.
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