FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387244803> ?p ?o ?g. }

• W4387244803 endingPage "1156" @default.
• W4387244803 startingPage "1147" @default.
• W4387244803 abstract "BackgroundCarriers of cancer predisposing variants are at an increased risk of developing subsequent malignant neoplasms among those who have survived childhood cancer. We aimed to investigate whether cancer predisposing variants contribute to the risk of subsequent malignant neoplasm-related late mortality (5 years or more after diagnosis).MethodsIn this analysis, data were included from two retrospective cohort studies, St Jude Lifetime Cohort (SJLIFE) and the Childhood Cancer Survivor Study (CCSS), with prospective follow-up of patients who were alive for at least 5 years after diagnosis with childhood cancer (ie, long-term childhood cancer survivors) with corresponding germline whole genome or whole exome sequencing data. Cancer predisposing variants affecting 60 genes associated with well-established autosomal-dominant cancer-predisposition syndromes were characterised. Subsequent malignant neoplasms were graded using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.03 with modifications. Cause-specific late mortality was based on linkage with the US National Death Index and systematic cohort follow up. Fine-Gray subdistribution hazard models were used to estimate subsequent malignant neoplasm-related late mortality starting from the first biospecimen collection, treating non-subsequent malignant neoplasm-related deaths as a competing risk, adjusting for genetic ancestry, sex, age at diagnosis, and cancer treatment exposures. SJLIFE (NCT00760656) and CCSS (NCT01120353) are registered with ClinicalTrials.gov.Findings12 469 (6172 male and 6297 female) participants were included, 4402 from the SJLIFE cohort (median follow-up time since collection of the first biospecimen 7·4 years [IQR 3·1–9·4]) and 8067 from the CCSS cohort (median follow-up time since collection of the first biospecimen 12·6 years [2·2–16·6]). 641 (5·1%) of 12 469 participants carried cancer predisposing variants (294 [6·7%] in the SJLIFE cohort and 347 [4·3%] in the CCSS cohort), which were significantly associated with an increased severity of subsequent malignant neoplasms (CTCAE grade ≥4 vs grade <4: odds ratio 2·15, 95% CI 1·18–4·19, p=0·0085). 263 (2·1%) subsequent malignant neoplasm-related deaths (44 [1·0%] in the SJLIFE cohort; and 219 [2·7%] in the CCSS cohort) and 426 (3·4%) other-cause deaths (103 [2·3%] in SJLIFE; and 323 [4·0%] in CCSS) occurred. Cumulative subsequent malignant neoplasm-related mortality at 10 years after the first biospecimen collection in carriers of cancer predisposing variants was 3·7% (95% CI 1·2–8·5) in SJLIFE and 6·9% (4·1–10·7) in CCSS versus 1·5% (1·0–2·1) in SJLIFE and 2·1% (1·7–2·5) in CCSS in non-carriers. Carrying a cancer predisposing variant was associated with an increased risk of subsequent malignant neoplasm-related mortality (SJLIFE: subdistribution hazard ratio 3·40 [95% CI 1·37–8·43]; p=0·0082; CCSS: 3·58 [2·27–5·63]; p<0·0001).InterpretationIdentifying participants at increased risk of subsequent malignant neoplasms via genetic counselling and clinical genetic testing for cancer predisposing variants and implementing early personalised cancer surveillance and prevention strategies might reduce the substantial subsequent malignant neoplasm-related mortality burden.FundingAmerican Lebanese Syrian Associated Charities and US National Institutes of Health." @default.
• W4387244803 created "2023-10-03" @default.
• W4387244803 creator A5000805822 @default.
• W4387244803 creator A5008672006 @default.
• W4387244803 creator A5008754414 @default.
• W4387244803 creator A5011526538 @default.
• W4387244803 creator A5013015739 @default.
• W4387244803 creator A5020052772 @default.
• W4387244803 creator A5025442855 @default.
• W4387244803 creator A5025610733 @default.
• W4387244803 creator A5030319840 @default.
• W4387244803 creator A5030921044 @default.
• W4387244803 creator A5033767117 @default.
• W4387244803 creator A5037102607 @default.
• W4387244803 creator A5037634832 @default.
• W4387244803 creator A5038183729 @default.
• W4387244803 creator A5038361086 @default.
• W4387244803 creator A5039782317 @default.
• W4387244803 creator A5041737379 @default.
• W4387244803 creator A5043738456 @default.
• W4387244803 creator A5054920686 @default.
• W4387244803 creator A5059262359 @default.
• W4387244803 creator A5059960472 @default.
• W4387244803 creator A5060175849 @default.
• W4387244803 creator A5063912603 @default.
• W4387244803 creator A5064287277 @default.
• W4387244803 creator A5065573166 @default.
• W4387244803 creator A5067443773 @default.
• W4387244803 creator A5073492643 @default.
• W4387244803 creator A5078535393 @default.
• W4387244803 creator A5085251424 @default.
• W4387244803 creator A5085263272 @default.
• W4387244803 creator A5089743648 @default.
• W4387244803 creator A5090366405 @default.
• W4387244803 creator A5026878443 @default.
• W4387244803 date "2023-10-01" @default.
• W4387244803 modified "2023-10-16" @default.
• W4387244803 title "Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study" @default.
• W4387244803 cites W1558704041 @default.
• W4387244803 cites W1839076539 @default.
• W4387244803 cites W1894979576 @default.
• W4387244803 cites W2015758016 @default.
• W4387244803 cites W2018538091 @default.
• W4387244803 cites W2038981426 @default.
• W4387244803 cites W2073140442 @default.
• W4387244803 cites W2101807916 @default.
• W4387244803 cites W2121411489 @default.
• W4387244803 cites W2144410376 @default.
• W4387244803 cites W2154866190 @default.
• W4387244803 cites W2163726181 @default.
• W4387244803 cites W2165854883 @default.
• W4387244803 cites W2256016639 @default.
• W4387244803 cites W2323716083 @default.
• W4387244803 cites W2480841917 @default.
• W4387244803 cites W2567469168 @default.
• W4387244803 cites W2752414510 @default.
• W4387244803 cites W2806161996 @default.
• W4387244803 cites W2969606220 @default.
• W4387244803 cites W2980780905 @default.
• W4387244803 cites W3027335902 @default.
• W4387244803 cites W3033780291 @default.
• W4387244803 cites W3114059671 @default.
• W4387244803 cites W4290659386 @default.
• W4387244803 cites W4319827716 @default.
• W4387244803 cites W4362602783 @default.
• W4387244803 doi "https://doi.org/10.1016/s1470-2045(23)00403-5" @default.
• W4387244803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37797633" @default.
• W4387244803 hasPublicationYear "2023" @default.
• W4387244803 type Work @default.
• W4387244803 citedByCount "1" @default.
• W4387244803 crossrefType "journal-article" @default.
• W4387244803 hasAuthorship W4387244803A5000805822 @default.
• W4387244803 hasAuthorship W4387244803A5008672006 @default.
• W4387244803 hasAuthorship W4387244803A5008754414 @default.
• W4387244803 hasAuthorship W4387244803A5011526538 @default.
• W4387244803 hasAuthorship W4387244803A5013015739 @default.
• W4387244803 hasAuthorship W4387244803A5020052772 @default.
• W4387244803 hasAuthorship W4387244803A5025442855 @default.
• W4387244803 hasAuthorship W4387244803A5025610733 @default.
• W4387244803 hasAuthorship W4387244803A5026878443 @default.
• W4387244803 hasAuthorship W4387244803A5030319840 @default.
• W4387244803 hasAuthorship W4387244803A5030921044 @default.
• W4387244803 hasAuthorship W4387244803A5033767117 @default.
• W4387244803 hasAuthorship W4387244803A5037102607 @default.
• W4387244803 hasAuthorship W4387244803A5037634832 @default.
• W4387244803 hasAuthorship W4387244803A5038183729 @default.
• W4387244803 hasAuthorship W4387244803A5038361086 @default.
• W4387244803 hasAuthorship W4387244803A5039782317 @default.
• W4387244803 hasAuthorship W4387244803A5041737379 @default.
• W4387244803 hasAuthorship W4387244803A5043738456 @default.
• W4387244803 hasAuthorship W4387244803A5054920686 @default.
• W4387244803 hasAuthorship W4387244803A5059262359 @default.
• W4387244803 hasAuthorship W4387244803A5059960472 @default.
• W4387244803 hasAuthorship W4387244803A5060175849 @default.
• W4387244803 hasAuthorship W4387244803A5063912603 @default.
• W4387244803 hasAuthorship W4387244803A5064287277 @default.
• W4387244803 hasAuthorship W4387244803A5065573166 @default.
• W4387244803 hasAuthorship W4387244803A5067443773 @default.

• next